Zobrazeno 1 - 10
of 422
pro vyhledávání: '"Xian En Zhang"'
Autor:
Nan Shao, Chenshuo Ren, Tianyuan Hu, Dianbing Wang, Xiaofan Zhu, Min Li, Tao Cheng, Yingchi Zhang, Xian-En Zhang
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Acute myeloid leukaemia (AML) is characterised by the malignant accumulation of myeloid progenitors with a high recurrence rate after chemotherapy. Blasts (leukaemia cells) exhibit a complete myeloid differentiation hierarchy hidi
Externí odkaz:
https://doaj.org/article/d0b7353eb9f34c9db8be013bdc62389d
Publikováno v:
BioDesign Research, Vol 6 (2024)
Messenger RNA (mRNA) therapeutics hold great potential in the prevention and treatment of many diseases owing to several unique advantages. Delivery of mRNA into target cells is a critical step in mRNA therapy. Efficient and safe delivery systems rem
Externí odkaz:
https://doaj.org/article/b5c966e0b17342ed81244beffb876ed3
Autor:
Li Wan, Peilei Hu, Lili Zhang, Zhao-Xi Wang, Joy Fleming, Bo Ni, Jianjun Luo, Cha-Xiang Guan, Liqiong Bai, Yunhong Tan, Haican Liu, Na Li, Tongyang Xiao, Hua Bai, Yong-An Zhang, Xian-En Zhang, Kanglin Wan, Lijun Bi, Songying Ouyang, Hongtai Zhang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
A multi-omic analysis of 11 Mycobacterium tuberculosis (Mtb) isolates with different drug resistance profiles leads to the discovery of Rv3094c, an enzyme capable of activating the clinically relevant Mtb drug, ethionamide.
Externí odkaz:
https://doaj.org/article/f339eb7018594782a51c882f29bbd3d8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Illuminating DNA and RNA dynamics in live cell can elucidate their life cycle and related biochemical activities. Various protocols have been developed for labeling the regions of interest in DNA and RNA molecules with different types of fluorescent
Externí odkaz:
https://doaj.org/article/9e3db40fda524400bacc192c398f7531
Publikováno v:
Antibiotics, Vol 13, Iss 1, p 13 (2023)
Tuberculosis remains a serious challenge to human health worldwide. para-Aminosalicylic acid (PAS) is an important anti-tuberculosis drug, which requires sequential activation by Mycobacterium tuberculosis (M. tuberculosis) dihydropteroate synthase a
Externí odkaz:
https://doaj.org/article/f75176815c2b4fc39c1a899e4e112942
Autor:
Ruqin Lin, Mingzhong Xiao, Shanshan Cao, Yu Sun, Linhua Zhao, Xiaoxiao Mao, Peng Chen, Xiaolin Tong, Zheyuan Ou, Hui Zhu, Dong Men, Xiaodong Li, Yiqun Deng, Xian‐En Zhang, Jikai Wen
Publikováno v:
mLife, Vol 1, Iss 2, Pp 183-197 (2022)
Abstract Gut microbiota composition is suggested to associate with coronavirus disease 2019 (COVID‐19) severity, but the impact of gut microbiota on health outcomes is largely unclear. We recruited 81 individuals from Wuhan, China, including 13 asy
Externí odkaz:
https://doaj.org/article/148f231e0525483c82fe34ee9c63f0f4
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011077 (2023)
Ebola virus (EBOV) causes severe hemorrhagic fever in humans with high mortality. In Ebola virus disease (EVD) survivors, EBOV persistence in the eyes may break through the inner blood-retinal barrier (iBRB), leading to ocular complications and EVD r
Externí odkaz:
https://doaj.org/article/75c832a018d7466fa40202056156fdcf
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT SARS-CoV-2 variants of concern (VOCs) pose a great challenge to viral prevention and treatment owing to spike (S) protein mutations, which enhance their infectivity and capacity for immune evasion. However, whether these S protein mutations
Externí odkaz:
https://doaj.org/article/bfb2f13dd90a471499f923da40165b25
Autor:
Heng Rong, Mi Qi, Jingdi Pan, Yuhan Sun, Jiawang Gao, Xiaowei Zhang, Wei Li, Bo Zhang, Xian-En Zhang, Zongqiang Cui
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The Zika virus (ZIKV) epidemic poses a substantial threat to the public, and the development of safe and effective vaccines is a demanding challenge. In this study, we constructed a kind of self-assembling nanovaccine which confers complete protectio
Externí odkaz:
https://doaj.org/article/6e65681c39e0415190a40ed0e92caca7
Autor:
Ashaq Ali, Muhammad Noman, Yong Guo, Xu Liu, Rong Zhang, Juan Zhou, Yang Zheng, Xian-En Zhang, Yong Qi, Xiaohua Chen, Dong Men
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Since the emergence of SARS-CoV-2, numerous studies have been attempting to determine biomarkers, which could rapidly and efficiently predict COVID-19 severity, however there is lack of consensus on a specific one. This retrospective cohort
Externí odkaz:
https://doaj.org/article/69e79bb73bcb4e36b06bc36a2df15011