ATG5 regulates type Ⅱ collagen expression by modulation of autophagy

Autor: DENG Lin, XIAN Menglin, YANG Yuyou

Publikováno v: 陆军军医大学学报, Vol 45, Iss 17, Pp 1828-1837 (2023)

Objective To explore the regulative effect of autophagy-related protein ATG5 on the expression of type Ⅱ collagen in human chondrocytes through affecting autophagy function. Methods Transcriptome data of 13 human cartilage tissue samples were downl

Externí odkaz: https://doaj.org/article/4559597bce834f3ca4cac84ef73a7ebd

Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis

Autor: Pan, Yiming, Yang, Yuyou, Fan, Mengtian, Chen, Cheng, Jiang, Rong, Liang, Li, Xian, Menglin, Kuang, Biao, Geng, Nana, Feng, Naibo, Deng, Lin, Zheng, Wei, Zhang, Fengmei, Li, Xiaoli, Guo, Fengjin

Publikováno v: In Genes & Diseases July 2023 10(4):1582-1595

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Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.

Autor: Kuang B; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Geng N; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Yi M; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Zeng Q; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Fan M; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Xian M; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Deng L; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Chen C; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Pan Y; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Kuang L; Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China., Luo F; Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China., Xie Y; Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China., Liu C; Department of Biomedical Engineering, College of Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Southern University of Science and Technology, Shenzhen, China., Deng Z; Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Nie M; Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China. Electronic address: 302218@cqmu.edu.cn., Du Y; Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China. Electronic address: duyu@hospital.cqmu.edu.cn., Guo F; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China. Electronic address: guo.fengjin@cqmu.edu.cn.

Publikováno v: Journal of advanced research [J Adv Res] 2024 Oct 21. Date of Electronic Publication: 2024 Oct 21.

The circUbqln1, regulated by XBP1s, interplays with 14-3-3ζ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism.

Autor: Feng N; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Ye Y; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Pan Y; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Kuang B; Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Du Y; Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Geng N; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Chen C; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Liu K; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Liang L; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Xian M; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Yang Y; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Li X; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Deng L; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Zhang F; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Kuang L; Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, China., Fan M; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Xie Y; Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, China., Guo F; State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China. Electronic address: guo.fengjin@cqmu.edu.cn.

Publikováno v: Journal of advanced research [J Adv Res] 2024 Jan 12. Date of Electronic Publication: 2024 Jan 12.