Výsledky vyhledávání - "Xia-Juan Huan"

Akademický článek

SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy

Autor: Li-Na Zhou, Chaodong Xiong, Yong-Jun Cheng, Shan-Shan Song, Xu-Bin Bao, Xia-Juan Huan, Tong-Yan Wang, Ao Zhang, Ze-Hong Miao, Jin-Xue He

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 32, Iss , Pp 100823- (2022)

Inhibition of the NEDD8-activating enzyme (NAE), the key E1 enzyme in the neddylation cascade, has been considered an attractive anticancer strategy with the discovery of the first-in-class NAE inhibitor, MLN4924. In this study, we identified SOMCL-1

Externí odkaz: https://doaj.org/article/b631d181d8ac4e6eaba5e0c1b074aaac

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Akademický článek

Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer

Autor: Ning Zhang, Yu-Nan Tian, Li-Na Zhou, Meng-Zhu Li, Hua-Dong Chen, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Ao Zhang, Ze-Hong Miao, Jin-Xue He

Publikováno v: Cell Death and Disease, Vol 12, Iss 2, Pp 1-18 (2021)

Abstract Monotherapy with poly ADP-ribose polymerase (PARP) inhibitors results in a limited objective response rate (≤60% in most cases) in patients with homologous recombination repair (HRR)-deficient cancer, which suggests a high rate of resistan

Externí odkaz: https://doaj.org/article/aa58f0bfd0a740678bf052d1f92375c9

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Akademický článek

Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus

Autor: Yi Chen, Song-Wei Li, Fang-Zhou Yin, Min Yang, Xia-Juan Huan, Ze-Hong Miao, Xiao-Ming Wang, Yue-Wei Guo

Publikováno v: Natural Products and Bioprospecting, Vol 11, Iss 1, Pp 73-79 (2020)

Abstract A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole alkaloid, named lagerindicine (1), along with four known compounds (2–5). Their structur

Externí odkaz: https://doaj.org/article/1a0a037f41294675a63ee2710baeed29

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Akademický článek

Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa, Phyllidia coelestis, and Their Sponge-Prey Acanthella cavernosa

Autor: Qihao Wu, Wen-Ting Chen, Song-Wei Li, Jian-Yu Ye, Xia-Juan Huan, Margherita Gavagnin, Li-Gong Yao, Hong Wang, Ze-Hong Miao, Xu-Wen Li, Yue-Wei Guo

Publikováno v: Marine Drugs, Vol 17, Iss 1, p 56 (2019)

A detailed chemical investigation of two South China Sea nudibranchs Phyllidiella pustulosa and Phyllidia coelestis, as well as their possible sponge-prey Acanthella cavernosa, led to the isolation of one new nitrogenous cadinane-type sesquiterpenoid

Externí odkaz: https://doaj.org/article/ef232921ee0d456691cd7fc865356ab3

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