Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Xia Bu"'
Autor:
Xiangling Xiao, Jie Shi, Chuan He, Xia Bu, Yishuang Sun, Minling Gao, Bolin Xiang, Wenjun Xiong, Panpan Dai, Qi Mao, Xixin Xing, Yingmeng Yao, Haisheng Yu, Gaoshan Xu, Siqi Li, Yan Ren, Baoxiang Chen, Congqing Jiang, Geng Meng, Yu-Ru Lee, Wenyi Wei, Gordon J. Freeman, Conghua Xie, Jinfang Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The programmed cell death protein 1 (PD-1) is an inhibitory receptor on T cells and plays an important role in promoting cancer immune evasion. While ubiquitin E3 ligases regulating PD-1 stability have been reported, deubiquitinases governin
Externí odkaz:
https://doaj.org/article/43341d084b874234849014855b8d8601
Autor:
Jing Liu, Xia Bu, Chen Chu, Xiaoming Dai, John M. Asara, Piotr Sicinski, Gordon J. Freeman, Wenyi Wei
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Activation of the cGAS/STING innate immunity pathway is essential and effective for anti-tumor immunotherapy. However, it remains largely elusive how tumor-intrinsic cGAS signaling is suppressed to facilitate tumorigenesis by escaping immune
Externí odkaz:
https://doaj.org/article/5f606d07d8a74f639c277fbbfdf52336
Autor:
Patrick Hwu, Apoorvi Chaudhri, Ping Hua, Xia Bu, Michael A Davies, Yunfei Wang, Shao-Hsi Hung, Ulrich Von Andrian, Gordon Freeman, Gregory A Lizee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/6e1a5c37223141a9b945039284ce6c08
Autor:
Apoorvi Chaudhri, Xia Bu, Yunfei Wang, Michael Gomez, James A. Torchia, Ping Hua, Shao-Hsi Hung, Michael A. Davies, Gregory A. Lizee, Ulrich von Andrian, Patrick Hwu, Gordon J. Freeman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migratio
Externí odkaz:
https://doaj.org/article/1cde7433a40e449fb498ea4bf76cfaa7
Autor:
Wenjun Xiong, Xueliang Gao, Tiantian Zhang, Baishan Jiang, Ming-Ming Hu, Xia Bu, Yang Gao, Lin-Zhou Zhang, Bo-Lin Xiao, Chuan He, Yishuang Sun, Haiou Li, Jie Shi, Xiangling Xiao, Bolin Xiang, Conghua Xie, Gang Chen, Haojian Zhang, Wenyi Wei, Gordon J. Freeman, Hong-Bing Shu, Haizhen Wang, Jinfang Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The regulatory mechanisms of PD-L1 posttranslational modifications are not completely understood. Here the authors show that USP8 negatively regulates PD-L1 protein abundance by removing the K63-linked ubiquitination of PD-L1; while USP8 inhibition i
Externí odkaz:
https://doaj.org/article/e769071990584a6aa031c02542686ae3
Autor:
Shengqing Stan Gu, Xiaoqing Wang, Xihao Hu, Peng Jiang, Ziyi Li, Nicole Traugh, Xia Bu, Qin Tang, Chenfei Wang, Zexian Zeng, Jingxin Fu, Cliff Meyer, Yi Zhang, Paloma Cejas, Klothilda Lim, Jin Wang, Wubing Zhang, Collin Tokheim, Avinash Das Sahu, Xiaofang Xing, Benjamin Kroger, Zhangyi Ouyang, Henry Long, Gordon J. Freeman, Myles Brown, X. Shirley Liu
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-28 (2020)
Abstract Background Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple studies have sought to identify general biomarkers of ICB response, but eluci
Externí odkaz:
https://doaj.org/article/b3244746e20a48e2bb9e322dbec655a3
Autor:
Peng Jiang, Xia Bu, Michael Manos, Ana Lako, Scott Rodig, Yingtian Xie, Shengqing Gu, Henry Long, Paloma Cejas, Gordon Freeman, Wubing Zhang, Xiaoqing Wang, Nicole Traugh, Ziyi Li, Clifford Meyer, Blair Stewig, Alba Font-Tello, Klothilda Lim, Jake Conway, Alok Tewari, Zexian Zeng, Avinash Das Sahu, Collin Tokheim, Jason Weirather, Jingxin Fu, Benjamin Kroger, Jin Hua Liang, Benjamin Gewurz, F. Stephen Hodi, Myles Brown, X Shirley Liu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/bab53d3c27fa4f8ba5c795696a9cf58b
Autor:
Stephanie Jemielity, Jinyize J Wang, Ying Kai Chan, Asim A Ahmed, Wenhui Li, Sheena Monahan, Xia Bu, Michael Farzan, Gordon J Freeman, Dale T Umetsu, Rosemarie H Dekruyff, Hyeryun Choe
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003232 (2013)
Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4) specifically bind phosphatidylserine (PS). TIM1 has been proposed to serve as a cellular receptor for hepatitis A virus and Ebola virus and as an entry factor for dengu
Externí odkaz:
https://doaj.org/article/3e0b25be82fb4447a20dffe357f3ec19
Autor:
X. Shirley Liu, Myles Brown, F. Stephen Hodi, Benjamin E. Gewurz, Henry W. Long, Scott Rodig, Gordon J. Freeman, Paloma Cejas, Jin Hua Liang, Benjamin Kroger, Yi Zhang, Jingxin Fu, Jason L. Weirather, Collin Tokheim, Avinash Das Sahu, Zexian Zeng, Alok K. Tewari, Jake Conway, Klothilda Lim, Ana Lako, Evisa Gjini, Alba Font-Tello, Michael P. Manos, Xia Bu, Yingtian Xie, Blair Stewig, Clifford Meyer, Ziyi Li, Nicole Traugh, Peng Jiang, Xiaoqing Wang, Wubing Zhang, Shengqing Stan Gu
RNA-seq and ATAC-seq of TRAF3-normal and -deficient B16F10 cells treated with vehicle control or IFNγ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a3314a396aff5c586317beda35765e
https://doi.org/10.1158/2159-8290.22540307
https://doi.org/10.1158/2159-8290.22540307
Autor:
X. Shirley Liu, Myles Brown, F. Stephen Hodi, Benjamin E. Gewurz, Henry W. Long, Scott Rodig, Gordon J. Freeman, Paloma Cejas, Jin Hua Liang, Benjamin Kroger, Yi Zhang, Jingxin Fu, Jason L. Weirather, Collin Tokheim, Avinash Das Sahu, Zexian Zeng, Alok K. Tewari, Jake Conway, Klothilda Lim, Ana Lako, Evisa Gjini, Alba Font-Tello, Michael P. Manos, Xia Bu, Yingtian Xie, Blair Stewig, Clifford Meyer, Ziyi Li, Nicole Traugh, Peng Jiang, Xiaoqing Wang, Wubing Zhang, Shengqing Stan Gu
Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based genome-wide CRISPR screens with a data-mining approach to identify drugs that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339909281206a9e55e90319937e3c2d6
https://doi.org/10.1158/2159-8290.c.6549347.v1
https://doi.org/10.1158/2159-8290.c.6549347.v1