Pirfenidone inhibits epidural scar fibroblast proliferation and differentiation by regulating TGF-β1-induced Smad-dependent and -independent pathways

Autor: Shi, Kun, Wang, Fengzhen, Xia, Jihua, Zuo, Bangjie, Wang, Zhaohong, Cao, Xiaojian

Epidural fibrosis causes serious complications in patients who have undergone laminectomy. Pirfenidone is an effective antifibrotic agent but its effect on epidural fibrosis remains unclear. In this study, we aimed to investigate the effect of pirfen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f157f8de540a2c521b8c25219f6822c3
https://europepmc.org/articles/PMC6456526/

Pirfenidone inhibits epidural scar fibroblast proliferation and differentiation by regulating TGF-β1-induced Smad-dependent and -independent pathways.

Autor: Shi K; Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road, Nanjing 210029, Jiangsu, China.; Department of Orthopedics, Xuzhou Central Hospital 199 South Jiefang Road, Xuzhou 221009, Jiangsu, China., Wang F; Department of Pharmaceutics, Affiliated Hospital of Xuzhou Medical University 99 Huaihai Road, Xuzhou 221002, Jiangsu, China., Xia J; Department of Orthopedics, Xuzhou Central Hospital 199 South Jiefang Road, Xuzhou 221009, Jiangsu, China., Zuo B; Department of Nephrology, Affiliated Hospital of Xuzhou Medical University Xuzhou 221002, Jiangsu, China., Wang Z; Department of Orthopedics, Xuzhou Central Hospital 199 South Jiefang Road, Xuzhou 221009, Jiangsu, China., Cao X; Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road, Nanjing 210029, Jiangsu, China.

Publikováno v: American journal of translational research [Am J Transl Res] 2019 Mar 15; Vol. 11 (3), pp. 1593-1604. Date of Electronic Publication: 2019 Mar 15 (Print Publication: 2019).