Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Xi-sha Chen"'
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The deregulation of DNA repair pathways is associated with the initiation and progression o
Externí odkaz:
https://doaj.org/article/ed52afba1e8a40c8a72ad1497f451630
Autor:
Pian Yu, Ao-xue Li, Xi-sha Chen, Min Tian, Hai-yan Wang, Xin-luan Wang, Yi Zhang, Kuan-song Wang, Yan Cheng
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The M2 isoform of pyruvate kinase (PKM2), as a key glycolytic enzyme, plays important roles in tumorigenesis and chemotherapeutic drug resistance. However, the intricate mechanism of PKM2 as a protein kinase regulating breast cancer progression and t
Externí odkaz:
https://doaj.org/article/1b64edcee6e847d8b8578fba0671df06
Autor:
Da Zeng, Yan Cheng, Min Tian, Lan-ya Li, Song-shu Xiao, Hai-zhou Wu, Xin-luan Wang, Yi Zhang, Xi-Sha Chen
Publikováno v:
Acta Pharmacol Sin
Anexelekto (AXL), a member of the TYRO3-AXL-MER (TAM) family of receptor tyrosine kinases (RTK), is overexpressed in varieties of tumor tissues and promotes tumor development by regulating cell proliferation, migration and invasion. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2444943e09b359c369c7cac36651ce30
https://doi.org/10.1038/s41401-020-00546-8
https://doi.org/10.1038/s41401-020-00546-8
Autor:
Dong-Sheng Cao, Xi-Sha Chen, Kuansong Wang, Jin-Ming Yang, Yi-Di Guan, Lan-ya Li, Xin-luan Wang, Yongguang Tao, Yi Zhang, Minghua Wu, Mingzhu Yin, Xin-Yuan Sun, Xingcong Ren, Yan Cheng, Ao-Xue Li
Publikováno v:
Oncogene. 39:6704-6718
Autophagy can protect stressed cancer cell by degradation of damaged proteins and organelles. However, the regulatory mechanisms behind this cellular process remain incompletely understood. Here, we demonstrate that RSK2 (p90 ribosomal S6 kinase 2) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b663896f0dd0160190d0876c9b5998e
https://doi.org/10.1038/s41388-020-01447-0
https://doi.org/10.1038/s41388-020-01447-0
Autor:
Chong Liu, HanXue Huang, Zhao-Qian Liu, Zhi-Bin Wang, Yan Cheng, Jiang-Feng Fei, Xi-Sha Chen, Shi-long Jiang, Lan-ya Li, Ting Jiang
Publikováno v:
Chemico-biological interactions. 351
Our recent study demonstrated eIF3a loss contributes to vemurafenib resistance in melanoma by activating ERK. However, overexpression of eIF3a in the clinic is not feasible to produce vemurafenib re-sensitization, and ERK inhibitors combined with vem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45011bf0b4a2fe1ad6e8da2a977f40d4
https://pubmed.ncbi.nlm.nih.gov/34813779
https://pubmed.ncbi.nlm.nih.gov/34813779
Publikováno v:
Acta Pharmacol Sin
Eukaryotic elongation factor-2 kinase (eEF-2K), a negative regulator of protein synthesis, has been shown to play an important role in modulating autophagy and apoptosis in tumor cells under various stresses. In this study, we investigated the regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1903a6c0f593f375a68c5559392641b
https://doi.org/10.1038/s41401-019-0222-z
https://doi.org/10.1038/s41401-019-0222-z
Autor:
Hai-yan Wang, Hui Wei, Feng Qiu, Shi-jie Cao, Pian Yu, Dong-Sheng Cao, Xi-sha Chen, Yi Zhang, Yan Cheng, Meng Zhang, Yongguang Tao
Publikováno v:
Acta pharmacologica Sinica. 43(6)
Physapubenolide (PB), a withanolide-type compound extracted from the traditional herb Physalis minima L., has been demonstrated to exert remarkable cytotoxicity against cancer cells; however, its molecular mechanisms are still unclear. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df572c313113cf78d72bd15b107ed701
https://pubmed.ncbi.nlm.nih.gov/34588618
https://pubmed.ncbi.nlm.nih.gov/34588618
Publikováno v:
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 56
Immunotherapies such as CAR-T cell transfer and antibody-targeted therapy have produced promising clinical outcomes in patients with advanced and metastatic cancer that are resistant to conventional therapies. However, with increasing use of cancer i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafe77906cbf4d2d3eff8680f2611847
https://pubmed.ncbi.nlm.nih.gov/33765484
https://pubmed.ncbi.nlm.nih.gov/33765484
Autor:
Shi-long Jiang, Yi-Di Guan, Jin-Ming Yang, Yi Zhang, Dong-Sheng Cao, Yan Cheng, Liu-Xia Zhang, Xi-Sha Chen, Alex F. Chen
Publikováno v:
European journal of medicinal chemistry. 199
It has been realized that FDA approved drugs may have more molecular targets than is commonly thought. Thus, to find the exact drug-target interactions (DTIs) is of great significance for exploring the new molecular mechanism of drugs. Here, we devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147c2b982e93b81e68bac677851e1897
https://pubmed.ncbi.nlm.nih.gov/32428794
https://pubmed.ncbi.nlm.nih.gov/32428794
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO3-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5a9037951705d01ed91a2f02c3650d
https://doi.org/10.1254/jpssuppl.wcp2018.0_po3-7-27
https://doi.org/10.1254/jpssuppl.wcp2018.0_po3-7-27