Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Xi-long Zheng"'
Publikováno v:
Journal of Advanced Research, Vol 63, Iss , Pp 207-218 (2024)
Background: Aging, a complex and profound journey, leads us through a labyrinth of physiological and pathological transformations, rendering us increasingly susceptible to aging-related diseases. Emerging investigations have unveiled the function of
Externí odkaz:
https://doaj.org/article/036944c09f8e4695852137b8a918b19d
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a human paracaspase protein with proteolytic activity via its caspase-like domain. The pharmacological inhibition of MALT1 by MI-2, a specific chemical inhibitor,
Externí odkaz:
https://doaj.org/article/07dbb6bad4024d5aa399a2ef7d8a6af9
Autor:
Yuting Cui, Yanyu Chen, Ni Gan, Man Li, Wei Liao, Yating Zhou, Qiong Xiang, Xi Gong, Qianqian Guo, Pengwei Hu, Xi-Long Zheng, Desi Shang, Juan Peng, Zhihan Tang
Publikováno v:
Molecular Biomedicine, Vol 4, Iss 1, Pp 1-15 (2023)
Abstract Atherosclerosis (AS) is a major contributor to morbidity and mortality worldwide. However, the molecular mechanisms and mediator molecules involved remain largely unknown. Copper, which plays an essential role in cardiovascular disease, has
Externí odkaz:
https://doaj.org/article/0fb7262f3fd64ae19483b277a018b2c7
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Neointima lesion and atherosclerosis are proliferative vascular diseases associated with deregulated proliferation of vascular smooth muscle cells (SMCs). CFI-400945 is a novel, highly effective anticancer drug that inhibits polo-like kinase
Externí odkaz:
https://doaj.org/article/f98653eed3db4c748f214c1b257303cf
Autor:
Shunchi Zhang, Yanrou Bei, Yueling Huang, Yimin Huang, Lianjie Hou, Xi-Long Zheng, Yiming Xu, Shaoguo Wu, Xiaoyan Dai
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-14 (2022)
Abstract Background Stent implantation-induced neointima formation is a dominant culprit in coronary artery disease treatment failure after percutaneous coronary intervention. Ferroptosis, an iron-dependent regulated cell death, has been associated w
Externí odkaz:
https://doaj.org/article/1032146eee404b1181379944ad6a5bbc
Autor:
Meng Wang, Rui Zhang, Jiang-Ping Shu, Xi-Long Zheng, Xin-Yi Wu, Jian-Bing Chen, Mei-Na Wang, Hui Shen, Yue-Hong Yan
Publikováno v:
Plants, Vol 13, Iss 4, p 521 (2024)
As the only aquatic lineage of Pteridaceae, Parkerioideae is distinct from many xeric-adapted species of the family and consists of the freshwater Ceratopteris species and the only mangrove ferns from the genus Acrostichum. Previous studies have show
Externí odkaz:
https://doaj.org/article/d7c1cf1334e947a091066f407f7e79e8
Autor:
Yaxiong Fang, Kongyang Ma, Yi-Min Huang, Yuanye Dang, Zhaoyu Liu, Yiming Xu, Xi-Long Zheng, Xiangdong Yang, Yongliang Huo, Xiaoyan Dai
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Upon migrating into the tissues, hematopoietic stem cell (HSC)-derived monocytes differentiate into macrophages, playing a crucial role in determining innate immune responses towards external pathogens and internal stimuli. However, the regulatory me
Externí odkaz:
https://doaj.org/article/3ba2cb50eb2342a89172b7033c24c592
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15160 (2023)
Endothelial cells (ECs) form the inner linings of blood vessels, and are directly exposed to endogenous hazard signals and metabolites in the circulatory system. The senescence and death of ECs are not only adverse outcomes, but also causal contribut
Externí odkaz:
https://doaj.org/article/f886fba52baf4e2883d3afaaa9c672e7
Autor:
Ni Zeng, Yu-Qing Huang, Yu-Min Yan, Zhi-Qin Hu, Zhuo Zhang, Jia-Xin Feng, Ji-Shen Guo, Jie-Ning Zhu, Yong-Heng Fu, Xi-Pei Wang, Meng-Zhen Zhang, Jin-Zhu Duan, Xi-Long Zheng, Jin-Dong Xu, Zhi-Xin Shan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1035-1050 (2021)
MicroRNA-199a-5p (miR-199a-5p) and -3p are enriched in the myocardium, but it is unknown whether miR-199a-5p and -3p are co-expressed in cardiac remodeling and what roles they have in cardiac hypertrophy and fibrosis. We show that miR-199a-5p and -3p
Externí odkaz:
https://doaj.org/article/e264f9859a5f4bd783e488783367e2ec
Autor:
Binjie Yan, Yu Gui, Yanan Guo, Jiaxing Sun, Mahmoud Saifeddine, Jingti Deng, Joseph A. Hill, Morley D. Hollenberg, Zhi-Sheng Jiang, Xi-Long Zheng
Publikováno v:
Cells, Vol 12, Iss 11, p 1461 (2023)
(+)-JQ1, a specific chemical inhibitor of bromodomain and extraterminal (BET) family protein 4 (BRD4), has been reported to inhibit smooth muscle cell (SMC) proliferation and mouse neointima formation via BRD4 regulation and modulate endothelial nitr
Externí odkaz:
https://doaj.org/article/535596f615e049e9b1c483968d52f6c2