Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Xi-Nan Shi"'
Autor:
Ying Zhu, Kun-Bin Ke, Zhong-Kun Xia, Hong-Jian Li, Rong Su, Chao Dong, Feng-Mei Zhou, Lin Wang, Rong Chen, Shi-Guo Wu, Hui Zhao, Peng Gu, Kwong-Sak Leung, Man-Hon Wong, Gang Lu, Jian-Ying Zhang, Bing-Hua Jiang, Jian-Ge Qiu, Xi-Nan Shi, Marie Chia-mi Lin
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-14 (2021)
Abstract Background Cyclin-dependent kinases 2/4/6 (CDK2/4/6) play critical roles in cell cycle progression, and their deregulations are hallmarks of hepatocellular carcinoma (HCC). Methods We used the combination of computational and experimental ap
Externí odkaz:
https://doaj.org/article/b3feca6eb5344562a341b0a3a071e3bd
Autor:
Zhong-Kun Xia, Wei Wang, Jian-Ge Qiu, Xi-Nan Shi, Hong-Jian Li, Rong Chen, Kun-Bin Ke, Chao Dong, Ying Zhu, Shi-Guo Wu, Rong-Ping Zhang, Zhuo-Ran Meng, Hui Zhao, Peng Gu, Kwong-Sak Leung, Man-Hon Wong, Xiao-Dong Liu, Feng-Mei Zhou, Jian-Ying Zhang, Ya-Ting Yao, Si-Jia Wang, Chun-Yang Zhang, Yan-Ru Qin, Marie Chia-mi Lin, Bing-Hua Jiang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Hepatocellular carcinoma (HCC) is a lethal malignancy lacking effective treatment. The Cyclin-dependent kinases 4/6 (CDK4/6) and PI3K/AKT signal pathways play pivotal roles in carcinogenesis and are promising therapeutic targets for HCC.
Externí odkaz:
https://doaj.org/article/8c577fa7534e405a9a6ce01a297274b9
Autor:
Xi-Nan Shi, Hongjian Li, Hong Yao, Xu Liu, Ling Li, Kwong-Sak Leung, Hsiang-fu Kung, Di Lu, Man-Hon Wong, Marie Chia-mi Lin
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132072 (2015)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Surgical resection and conventional chemotherapy and radiotherapy ultimately fail due to tumor recurrence and HCC's resistance. The development of novel t
Externí odkaz:
https://doaj.org/article/502d622cdedb4e349c393ff4291c3b59
Autor:
Yi Yang, Ceshi Chen, Kunbin Ke, Hongjian Li, Chao Dong, Xu Liu, Jing Ma, Ling Li, Marie Chia-mi Lin, Hsiang-Fu Kung, Yin Chen, Hongtao Zhang, Xi-Nan Shi
Publikováno v:
International Journal of Biological Sciences
Background: The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is hyperactivated in lung cancer and regulates a broad range of cellular processes, including proliferation, survival, angiogenesis, and metastasis. Thus PI3K is considered a
Autor:
Ying Zhu, Kun-Bin Ke, Zhong-Kun Xia, Hong-Jian Li, Rong Su, Chao Dong, Feng-Mei Zhou, Lin Wang, Rong Chen, Shi-Guo Wu, Hui Zhao, Peng Gu, Kwong-Sak Leung, Man-Hon Wong, Gang Lu, Jian-Ying Zhang, Bing-Hua Jiang, Jian-Ge Qiu, Xi-Nan Shi, Marie Chia-mi Lin
Background: Cyclin-dependent kinases 2/4/6 (CDK2/4/6) play critical roles in cell cycle progression, and their deregulations are hallmarks of hepatocellular carcinoma (HCC). Methods: We used the combination of computational and experimental approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d6455aec1d43e159509b3cbc132d94c
https://doi.org/10.21203/rs.3.rs-29276/v3
https://doi.org/10.21203/rs.3.rs-29276/v3
Autor:
Peng Gu, Kunbin Ke, Rong Chen, Xi-Nan Shi, Bing-Hua Jiang, Hongjian Li, Man Hon Wong, Feng-Mei Zhou, Hui Zhao, Jianying Zhang, Lin Wang, Jian-Ge Qiu, Rong Su, Ying Zhu, Shi-Guo Wu, Zhong-Kun Xia, Marie Chia-mi Lin, Chao Dong, Kwong-Sak Leung, Gang Lu
Publikováno v:
Molecular Medicine
Molecular Medicine, Vol 27, Iss 1, Pp 1-14 (2021)
Molecular Medicine, Vol 27, Iss 1, Pp 1-14 (2021)
Background Cyclin-dependent kinases 2/4/6 (CDK2/4/6) play critical roles in cell cycle progression, and their deregulations are hallmarks of hepatocellular carcinoma (HCC). Methods We used the combination of computational and experimental approaches
Autor:
Ceshi Chen, Runxiang Yang, Guimiao Lin, Man Hon Wong, Kunbin Ke, Chunxiang Luo, Hongjian Li, Xiaomei Wang, Xu Liu, Chao Dong, Fang Yang, Ying Zhu, Xi-Nan Shi, Kwong-Sak Leung, Hsiang-Fu Kung, Marie Chia-mi Lin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
The phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway plays a pivotal role in many cellular processes, including the proliferation, survival and differentiation of lung cancer cells. Thus, PI3K is a promising therapeutic target for lung canc
Autor:
Kwong-Sak Leung, Ying Zhu, Chao Dong, Marie Chia-mi Lin, Man Hon Wong, Kunbin Ke, Ling Li, Hong Yao, Xi-Nan Shi, Xiao-Dong Liu, Hongjian Li, Xu Liu, Hsiang-Fu Kung
Publikováno v:
Chemical Biology & Drug Design. 89:505-513
Bladder carcinoma (BC) is the ninth most common cause of cancer worldwide. Surgical resection and conventional chemotherapy and radiotherapy will ultimately fail due to tumor recurrence and resistance. Thus, the development of novel treatment is urge
Autor:
XI-NAN SHI1,2, HONGJIAN LI3, HONG YAO4,5, XU LIU1, LING LI1, KWONG-SAK LEUNG3, HSIANG-FU KUNG1,5, MARIE CHIA-MI LIN1,6 mcmlin@163.com
Publikováno v:
Molecular Medicine Reports. 2015, Vol. 12 Issue 5, p6501-6508. 8p.
Autor:
Marie Chia‑Mi Lin, Man Hon Wong, Xi-Nan Shi, Hongjian Li, Kunbin Ke, Anhua Shi, Kwong-Sak Leung, Wei Chen, Qingshan Hai, Yi Qin, Xu Liu, Ling Li, Ying Zhu, Ying Ding, Hong Yao, Chao Dong, Ling Lei, Hsiang-Fu Kung, Yan Hong He
Publikováno v:
Oncology Reports.
Since cyclin‑dependent kinases 4/6 (CDK4/6) play pivotal roles in cell cycle regulation and are overexpressed in human skin cancers, CDK4/6 inhibitors are potentially effective drugs for skin cancer. In the present study, we present a mixed computa