Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice

Autor: Pan Zhang, Ze-Lin Lai, Hui-Fen Chen, Min Zhang, An Wang, Tao Jia, Wen-Qin Sun, Xi-Min Zhu, Xiao-Feng Chen, Zheng Zhao, Jun Zhang

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-12 (2017)

Abstract Background Chemoresistance is a major obstacle that limits the benefits of 5-Fluorouracil (5-Fu)-based chemotherapy for colon cancer patients. Autophagy is an important cellular mechanism underlying chemoresistance. Recent research advances

Externí odkaz: https://doaj.org/article/161414d816fe4a6eab0d5af022c23ac6

Effects of Highway-Related Pollutant on the Groundwater Quality of Turfy Swamps in the Changbai Mountain Area.

Autor: Wang H; Construction Engineering College, Jilin University, Xi Min Zhu Street, Changchun 130026, Jilin, China. wanghong15@mails.jlu.edu.cn., Nie L; Construction Engineering College, Jilin University, Xi Min Zhu Street, Changchun 130026, Jilin, China. nielei@jlu.edu.cn., Xu Y; Construction Engineering College, Jilin University, Xi Min Zhu Street, Changchun 130026, Jilin, China. xuyan8102@jlu.edu.cn., Du C; Construction Engineering College, Jilin University, Xi Min Zhu Street, Changchun 130026, Jilin, China. duchao16@mails.jlu.edu.cn., Zhang T; Construction Engineering College, Jilin University, Xi Min Zhu Street, Changchun 130026, Jilin, China. zhangtao16@mails.jlu.edu.cn., Wang Y; Construction Engineering College, Jilin University, Xi Min Zhu Street, Changchun 130026, Jilin, China. wangyz16@mails.jlu.edu.cn.

Publikováno v: International journal of environmental research and public health [Int J Environ Res Public Health] 2018 Aug 03; Vol. 15 (8). Date of Electronic Publication: 2018 Aug 03.