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Akademický článek

Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord.

Autor: Xiao-Qian Li, Zai-Li Zhang, Wen-Fei Tan, Xi-Jia Sun, Hong Ma

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0163807 (2016)

Toll-like receptor 4 (TLR4) is important for the pathogenesis of inflammatory reactions and the promotion of pain processing after ischemia/reperfusion (IR) in spinal cord. Recently, C-X-C chemokine ligand 12 (CXCL12) and its receptor, C-X-C chemokin

Externí odkaz: https://doaj.org/article/81a13dd6675740c9bf61157ab435841a

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MiR-187-3p mimic alleviates ischemia-reperfusion-induced pain hypersensitivity through inhibiting spinal P2X7R and subsequent mature IL-1β release in mice

Autor: Hong Ma, Xi-Jia Sun, Qian Yu, Zai-Li Zhang, Xiao-Qian Li

Publikováno v: Brain, Behavior, and Immunity. 79:91-101

Background Ischemia-reperfusion (IR)-induced pain hypersensitivity shares features of neuroinflammation and neuropathic pain, accompanied by overproduction of interleukin (IL)-1β. Multiple microRNAs (miRs) are dysregulated during IR; among these miR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835ec1f758c8b8350af3557616b10c5b
https://doi.org/10.1016/j.bbi.2019.05.021

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Exendin-4 improves behaviorial deficits via GLP-1/GLP-1R signaling following partial hepatectomy

Autor: Zhe Li, Hong Ma, Paul F. White, Xuezhao Cao, Xi-Jia Sun, Yong Cui, Yongjian Zhou, Xiaohan Xu, Yanhua Jiang

Publikováno v: Brain Research. 1706:116-124

Recent studies indicate that glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonists exhibit neurotrophic and neuroprotective effects. The aim of this study was to explore whether the GLP-1R agonist exendin-4 can alter surgery-induced behavioral d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4e4503258e36d1b166b643d3ff922b
https://doi.org/10.1016/j.brainres.2018.11.007

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Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice

Autor: Jun Wang, Yanhua Jiang, Hong Ma, Fang Liu, Xuezhao Cao, Xiao-Qian Li, Xi-Jia Sun, Zhe Li, Ayong Tian

Publikováno v: Cellular Physiology and Biochemistry, Vol 46, Iss 4, Pp 1398-1411 (2018)

Background/Aims: TREM2 plays a crucial role in modulating microglial function through interaction with DAP12, the adapter for TREM2. Emerging evidence has demonstrated that TREM2 could suppress neuroinflammatory responses by repression of microglia-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b638bc380d0836732df9fa9fec09b2e9
https://www.karger.com/Article/FullText/489155

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Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord

Autor: Xi-Jia Sun, Wen-Fei Tan, Zai-Li Zhang, Hong Ma, Xiao-Qian Li

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0163807 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f376d8f18c3bd37f2b768137792d9a
https://pubmed.ncbi.nlm.nih.gov/27760212

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Sevoflurane Inhibits Nuclear Factor-κB Activation in Lipopolysaccharide-Induced Acute Inflammatory Lung Injury via Toll-Like Receptor 4 Signaling

Autor: Xiao Qian Li, Xi Jia Sun, Wen Fei Tan, Xiaolong Wang, Jun Ke Wang

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0122752 (2015)

Background Infection is a common cause of acute lung injury (ALI). This study was aimed to explore whether Toll-like receptors 4 (TLR4) of airway smooth muscle cells (ASMCs) play a role in lipopolysaccharide (LPS)-induced airway hyperresponsiveness a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7426c831188339d6db67af8a011dfd7b
http://europepmc.org/articles/PMC4397052

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Ischemic Preconditioning Protects against Spinal Cord Ischemia-Reperfusion Injury in Rabbits by Attenuating Blood Spinal Cord Barrier Disruption

Autor: Xi-Jia Sun, Hong Ma, Bo Fang, Huang-Wei Lv, Na-Ren Bao, Xiao-Yan Ren, Xiaoman Li

Publikováno v: International Journal of Molecular Sciences; Volume 14; Issue 5; Pages: 10343-10354
International Journal of Molecular Sciences, Vol 14, Iss 5, Pp 10343-10354 (2013)
International Journal of Molecular Sciences

Ischemic preconditioning has been reported to protect against spinal cord ischemia-reperfusion (I-R) injury, but the underlying mechanisms are not fully understood. To investigate this, Japanese white rabbits underwent I-R (30 min aortic occlusion fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2789c3de635a0f7fe42700ecf3ad0e

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