Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Xi-De Wang"'
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54415 (2013)
The causal role of the hedgehog pathway in cancer has been best documented in basal cell carcinoma of the skin. To assess potential DNA alterations of the hedgehog pathway in gastric cancer, we sequenced SMO and PTCH1 genes in a set of 39 gastric tum
Externí odkaz:
https://doaj.org/article/2940382625a84b8f9212aa9427b6e19d
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2186 (2008)
Although Wnt signaling has been shown to be important for embryonic morphogenesis and cancer pathogenesis of several tissues, its role in prostatic development and tumorigenesis is not well understood. Here we show that Wnt signaling regulated prosta
Externí odkaz:
https://doaj.org/article/c2b46ed2fc8d46ba9399cc5abcfac684
Autor:
Alan P. Skarbnik, Franklin L. Chen, Luke Mountjoy, Zaw Win Myint, Patricia A. Young, Andrew R. Whiteley, Steven Novick, Jennifer Su, Qingxi Wang, Kevin Romanko, Xi-De Wang, Yejia Li, Shulin Zhong, Liping Song, Ranjana H. Advani
Publikováno v:
Blood. 140:12059-12060
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2adeb9b061ab0dc3e07bb94032fa091
https://doi.org/10.1182/blood-2022-164746
https://doi.org/10.1182/blood-2022-164746
Autor:
Bu-Er Wang, Robert Soriano, Xi-De Wang, Wei-Qiang Gao, Zora Modrusan, Gerald R. Cunha, Jiping Zha, Zemin Zhang
Publikováno v:
Differentiation. 75:219-234
Mice have been used extensively for studying normal prostate development and for generation of transgenic or knock-out prostate cancer animal models. To understand systematically and thoroughly the androgen responsive program in the mouse prostate, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b11998ffe8dae8fa8fc6a93bf25d29
https://doi.org/10.1111/j.1432-0436.2006.00135.x
https://doi.org/10.1111/j.1432-0436.2006.00135.x
Publikováno v:
The Prostate. 65(1)
BACKGROUND In order to facilitate elucidation of oncogene or tumor suppressor gene function on initiation and progression of prostate cancer, it would be advantageous to develop an effective method to generate spatially and temporally controlled gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06029245a9081ebf963e27a22cc66588
https://pubmed.ncbi.nlm.nih.gov/15791629
https://pubmed.ncbi.nlm.nih.gov/15791629
Publikováno v:
The Journal of biological chemistry. 279(23)
Notch expression is frequently associated with progenitor cells, and its function is crucial for development. Our recent work showing that Notch1 is selectively expressed in basal epithelial cells of the prostate and higher Notch1 expression during d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400b509a560c98161ea030a8977970f5
https://pubmed.ncbi.nlm.nih.gov/15028713
https://pubmed.ncbi.nlm.nih.gov/15028713
Autor:
Peter E. M. Gibbs, Ziqiang Li, W. Glenn McGregor, Xi-De Wang, Terrence P. McManus, Veronica M. Maher, Christopher W. Lawrence
In Saccharomyces cerevisiae , most mutations induced by a wide range of mutagens arise during translesion replication employing the REV1 gene product and DNA polymerase ζ. As part of an effort to investigate mammalian mutagenic mechanisms, we have i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77992dc0555553e6e8b6626a63290ae
https://europepmc.org/articles/PMC18191/
https://europepmc.org/articles/PMC18191/
Autor:
Bethany S. Strunk, Xi De Wang, John Reinitz, Tory Priputin, Brandon A. Pabst, Carla Margulies, Dave Kosman, David N. Arnosti, Gavin F. Hewitt, Roxane L. Amey
Publikováno v:
Development (Cambridge, England). 126(6)
Early developmental patterning of the Drosophila embryo is driven by the activities of a diverse set of maternally and zygotically derived transcription factors, including repressors encoded by gap genes such as Krüppel, knirps, giant and the mesode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eaf07322b02253ab9b11c8716a84d11
https://pubmed.ncbi.nlm.nih.gov/10021339
https://pubmed.ncbi.nlm.nih.gov/10021339
Although conformational perturbation of the active sites of many enzymes has been reported to precede global molecular conformational changes [Tsou (1993) Science 262, 380–381], little effort has been made to compare the susceptibility of the ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7715579e8270c5c3f132e9cf3b09823b
https://europepmc.org/articles/PMC1218615/
https://europepmc.org/articles/PMC1218615/
Autor:
Kelly L. Bennett, Joseph Fargnoli, Anne Lewin, Leila Alland, Hewei Li, Fei Huang, Xi‐De Wang, Lixin Lang, Ping Zhan, Jan M.A. Van Tornout, Christoph Alhers, Ching-Ping Ho, Bruce Rowley, Donald R. Hawken
Publikováno v:
Molecular Cancer Therapeutics. 8:C18-C18
Background: Inhibition of the Hedgehog pathway using Smoothened antagonists is emerging as a promising targeted therapy for cancers with pathway activating mutations or dysregulated expression. In support of the clinical development of BMS-833923 (XL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4989a617449bef726ed3abd4b824619
https://doi.org/10.1158/1535-7163.targ-09-c18
https://doi.org/10.1158/1535-7163.targ-09-c18