Aberrant Hepatic MicroRNA Expression in Nonalcoholic Fatty Liver Disease

Autor: Yue Ying Feng, Xiao Qin Xu, Chen Bo Ji, Chun Mei Shi, Xi Rong Guo, Jun Fen Fu

Publikováno v: Cellular Physiology and Biochemistry, Vol 34, Iss 6, Pp 1983-1997 (2014)

Background/Aim: Emerging evidence suggests that microRNA (miRNA) mediated gene regulation influences the maintenance of metabolic homeostasis, particularly the states of obesity and insulin resistance, thereby providing a potential link between miRNA

Externí odkaz: https://doaj.org/article/fab5eabd4b9b4e709f6493164e93f7da

Approaches to addressing the rise in obesity levels

Autor: Caroline M. Apovian, Xi-Rong Guo, John A. Hawley, Shahzeer Karmali, Ruth J. F. Loos, Wilma E. Waterlander

Publikováno v: Apovian, C M, Guo, X-R, Hawley, J A, Karmali, S, Loos, R J F & Waterlander, W E 2023, ' Approaches to addressing the rise in obesity levels ', Nature Reviews. Endocrinology, vol. 19, no. 2, pp. 76-81 . https://doi.org/10.1038/s41574-022-00777-1
Nature Reviews. Endocrinology, 19(2), 76-81. Nature Publishing Group
Nature reviews. Endocrinology, 19(2), 76-81. Nature Publishing Group

Levels of obesity and overweight are increasing globally, with affected individuals often experiencing health issues and reduced quality of life. The pathogenesis of obesity is complex and multifactorial, and effective solutions have been elusive. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e28d0210daab778e83e92a012926e99
https://research.vumc.nl/en/publications/282e5c65-e377-4eb7-98bf-c9963b909075

Increased Locomotor Activity and Non-Selective Attention and Impaired Learning Ability in SD Rats after Lentiviral Vector-Mediated RNA Interference of Homer 1a in the Brain

Autor: Qin Hong, Lei Yang, Min Zhang, Xiao-Qin Pan, Mei Guo, Li Fei, Mei-Ling Tong, Rong-Hua Chen, Xi-Rong Guo, Xia Chi

Publikováno v: International Journal of Medical Sciences, Vol 10, Iss 1, Pp 90-102 (2013)

Our previous studies found that Homer 1a, a scaffolding protein localized at the post-synaptic density (PSD) of glutamatergic excitatory synapses, is significantly down-regulated in the brain of spontaneous hypertensive rats (SHR), an animal model of

Externí odkaz: https://doaj.org/article/88cd9e70a7284ad49673aad728aa46db

Deep Leaky Single-peaked Triangle Neural Networks

Autor: Chuan-Hui Shan, Jun Ou, Xi-Rong Guo

Publikováno v: International Journal of Control, Automation and Systems. 17:2693-2701

Recently, Deep learning has made a great deal of success in processing images, audios, and natural languages and so on. The activation function is one of the key factors in Deep learning. In this paper, according to characteristics of biological neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcb1cefe8f128918f688a63a60519774
https://doi.org/10.1007/s12555-018-0796-0

Tumor necrosis factor-α and interleukin-6 suppress microRNA-1275 transcription in human adipocytes through nuclear factor-κB

Autor: Xiao‑Hui Chen, Zi‑Yi Fu, Chen‑Bo Ji, Xi‑Rong Guo, Yu‑Feng Zhou, Yan Cui

Publikováno v: Molecular Medicine Reports

Obesity is a confirmed risk factor for hyperlipidemia, type‑II diabetes, hypertension, and cardiovascular disease. MicroRNAs (miRs) have emerged as an important field of study within energy metabolism and obesity. A previous study demonstrated miR�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff877e315687b11cec1225deae5daed
https://doi.org/10.3892/mmr.2017.7392