Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Xi Ping, Huang"'
Autor:
Kevin M. Knight, Brian E. Krumm, Nicholas J. Kapolka, W. Grant Ludlam, Meng Cui, Sepehr Mani, Iya Prytkova, Elizabeth G. Obarow, Tyler J. Lefevre, Wenyuan Wei, Ning Ma, Xi-Ping Huang, Jonathan F. Fay, Nagarajan Vaidehi, Alan V. Smrcka, Paul A. Slesinger, Diomedes E. Logothetis, Kirill A. Martemyanov, Bryan L. Roth, Henrik G. Dohlman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Many neurotransmitter receptors activate G proteins through exchange of GDP for GTP. The intermediate nucleotide-free state has eluded characterization, due largely to its inherent instability. Here we characterize a G protein variant associ
Externí odkaz:
https://doaj.org/article/a1bbb4b8f5a447f79e49586a70a5bd73
Autor:
Madigan L. Bedard, Xi-Ping Huang, Jackson G. Murray, Alexandra C. Nowlan, Sara Y. Conley, Sarah E. Mott, Samuel J. Loyack, Calista A. Cline, Caroline G. Clodfelter, Nabarun Dasgupta, Brian Krumm, Bryan L. Roth, Zoe A. McElligott
Publikováno v:
Addiction Neuroscience, Vol 12, Iss , Pp 100166- (2024)
Externí odkaz:
https://doaj.org/article/d3e43386ab474fea91977aa866095881
Autor:
Madigan L. Bedard, Xi-Ping Huang, Jackson G. Murray, Alexandra C. Nowlan, Sara Y. Conley, Sarah E. Mott, Samuel J. Loyack, Calista A. Cline, Caroline G. Clodfelter, Nabarun Dasgupta, Brian Krumm, Bryan L. Roth, Zoe A. McElligott
Publikováno v:
Addiction Neuroscience, Vol 11, Iss , Pp 100155- (2024)
Xylazine is in the unregulated drug supply at increasing rates, usually combined with fentanyl, necessitating understanding of its pharmacology. Despite commentary from politicians, and public health officials, it is unknown how xylazine impacts nalo
Externí odkaz:
https://doaj.org/article/3e128672d2564dee806e2490ca9492db
Autor:
Stefan Gahbauer, Chelsea DeLeon, Joao M. Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B. Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A. Fink, Ivan S. Kondratov, Yurii S. Moroz, John J. Irwin, Allan I. Basbaum, Bryan L. Roth, Brian K. Shoichet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce nociception by inhibiting prostagl
Externí odkaz:
https://doaj.org/article/5afef5b1703241589164379113e645d4
Autor:
Rabindra V. Shivnaraine, Brendan Kelly, Gwendolynne Elmslie, Xi-Ping Huang, Yue John Dong, Margaret Seidenberg, James W. Wells, John Ellis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Many G protein-coupled receptors (GPCRs) are therapeutic targets, with most drugs acting at the orthosteric site. Some GPCRs also possess allosteric sites, which have become a focus of drug discovery. In the M2 muscarinic receptor, allosteri
Externí odkaz:
https://doaj.org/article/68b8f45abdf448c890100bc734c1f038
Autor:
Bingjie Zhang, Simeng Zhao, Dehua Yang, Yiran Wu, Ye Xin, Haijie Cao, Xi-Ping Huang, Xiaoqing Cai, Wen Sun, Na Ye, Yueming Xu, Yao Peng, Suwen Zhao, Zhi-Jie Liu, Guisheng Zhong, Ming-Wei Wang, Wenqing Shui
Publikováno v:
ACS Central Science, Vol 6, Iss 2, Pp 213-225 (2020)
Externí odkaz:
https://doaj.org/article/f913f83afcbe47449810dd570d7d282f
Autor:
Brian E. Krumm, Jeffrey F. DiBerto, Reid H. J. Olsen, Hye Jin Kang, Samuel T. Slocum, Shicheng Zhang, Ryan T. Strachan, Xi-Ping Huang, Lauren M. Slosky, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron, Terry Kenakin, Jonathan F. Fay, Bryan L. Roth
Publikováno v:
Biochemistry. 62:1233-1248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e46ba96106037966aa36314ed803bd6d
https://doi.org/10.1021/acs.biochem.3c00029
https://doi.org/10.1021/acs.biochem.3c00029
Autor:
Robert W. Malone, Philip Tisdall, Philip Fremont-Smith, Yongfeng Liu, Xi-Ping Huang, Kris M. White, Lisa Miorin, Elena Moreno, Assaf Alon, Elise Delaforge, Christopher D. Hennecker, Guanyu Wang, Joshua Pottel, Robert V. Blair, Chad J. Roy, Nora Smith, Julie M. Hall, Kevin M Tomera, Gideon Shapiro, Anthony Mittermaier, Andrew C. Kruse, Adolfo García-Sastre, Bryan L. Roth, Jill Glasspool-Malone, Darrell O. Ricke
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not sufficient for development of clinical COVID-19 disease. Currently, there are no
Externí odkaz:
https://doaj.org/article/886e5d63bd85412f90473f81dc54eb9e
Autor:
Nilkanth Patel, Xi Ping Huang, Jessica M Grandner, Linda C Johansson, Benjamin Stauch, John D McCorvy, Yongfeng Liu, Bryan Roth, Vsevolod Katritch
Publikováno v:
eLife, Vol 9 (2020)
Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here, we performed large scale structure-based virtual screening for new liga
Externí odkaz:
https://doaj.org/article/ae3b26d29f104825bba96ae407a6e98e
Autor:
Shicheng Zhang, Ryan H. Gumpper, Xi-Ping Huang, Yongfeng Liu, Brian E. Krumm, Can Cao, Jonathan F. Fay, Bryan L. Roth
Publikováno v:
Nature. 612:354-362
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f67d762e394d0366b6e3fa9392def5bd
https://doi.org/10.1038/s41586-022-05489-0
https://doi.org/10.1038/s41586-022-05489-0