Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Xi M. Tang"'
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 39K, HT29 PLX4720 resistant clone was treated with EGFR siRNA for 48 h, and then treated with 1�M PLX4720 for further two weeks. EGFR knockdown reduced sensitivity to PLX4720 by numbers of formed colonies (# P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc22a97db08c50678f13fa79f95abaf
https://doi.org/10.1158/1078-0432.22445823.v1
https://doi.org/10.1158/1078-0432.22445823.v1
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 30K, BRAF mutant cell lines utilized in the RPPA analysis. Cells were lysed at approximately 70% confluence in 10% serum. Of note, Colo201 and Colo205 are derived from the same colon cancer patient, as are HT29 and WiDr. Cell lines were ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683ae81e3b5084501e2b3a8720ad7512
https://doi.org/10.1158/1078-0432.22445820
https://doi.org/10.1158/1078-0432.22445820
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 338K, Cells were incubated for 24h (HT29, Colon205) or 48 h (RKO) with PLX4720 (1 M for all cell lines), LY294002 (15 M for all cell lines) or their combination. Cells were then harvested and stained with propidium iodide. DNA concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e654ec4ff37df80a7793f4485bc57d9
https://doi.org/10.1158/1078-0432.22445841
https://doi.org/10.1158/1078-0432.22445841
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 36K, Cells were treated with PTEN siRNA for 48 h, and then treated with PLX4720 at doses near the individual IC50s for a further 72 h. (HT29: 0.01�M, Colo205: 0.05�M, Vaco5: 1 �M). HT29 contains an atypical and poorly characterized m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e293df9a92c229a5093b63ffdd095c8
https://doi.org/10.1158/1078-0432.22445844
https://doi.org/10.1158/1078-0432.22445844
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 44K, The combination therapy with PLX4720 and azacytidine was repeated in HT29 cells first treated with siRNA to PTEN . Silencing PTEN was not sufficient to fully abolish the synergy seen with the combination (* P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc535f2bd4e78c316ca65dd00d519cf
https://doi.org/10.1158/1078-0432.22445838
https://doi.org/10.1158/1078-0432.22445838
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
Purpose: Vemurafenib, a selective inhibitor of BRAFV600, has shown significant activity in BRAFV600 melanoma but not in less than 10% of metastatic BRAFV600 colorectal cancers (CRC), suggesting that studies of the unique hypermethylated phenotype and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd48f9e7d8f637f65399bc93580bcb7
https://doi.org/10.1158/1078-0432.c.6520569.v1
https://doi.org/10.1158/1078-0432.c.6520569.v1
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 36K, Correlation of EGFR and PTEN expression by RPPA and sensitivity to PLX4720. There is no statistically significant correlation between the EGFR expression level and sensitivity to PLX4720 (P=0.10, Spearman rank), although this is influ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e268410be45b8dbf4d8f9989cf6e1e8
https://doi.org/10.1158/1078-0432.22445847
https://doi.org/10.1158/1078-0432.22445847
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 38K, KRAS, BRAF, PIK3CA, and PTEN status of utilized CRC cell lines.The mutation data was obtained from the Sanger Institute Catalogue Of Somatic Mutations In Cancer web site, http://www.sanger.ac.uk/cosmic. Bamford et al (2004) The COSMIC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859750650e7ef8d264d886afcfd4797d
https://doi.org/10.1158/1078-0432.22445817
https://doi.org/10.1158/1078-0432.22445817
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 84K, HT29 and Colo205 parental and PLX-resistant (RC) cell lines subjected to FISH for EGFR. A) Representative fields from each of the 4 cell lines are shown below, with red EGFR probe and green Chr7 centromeric probe. B) FISH scoring conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d0d54cc418b6798894dace902ec352
https://doi.org/10.1158/1078-0432.22445829
https://doi.org/10.1158/1078-0432.22445829
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 140K, HT29 and Colo205 parental and PLX-resistant (RC) cell lines were profiled by Affymetrix MIP array (OncoScan� FFPE Express 2.0 Services) for copy number. The following copy number plots were produced by Affymetrix Nexus CN 6.0. (bui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7df08ef488a9448a7e3df278f8191e4
https://doi.org/10.1158/1078-0432.22445835
https://doi.org/10.1158/1078-0432.22445835