Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes

Autor: Takeshi, Fujisawa, Keqing, Wang, Xi-Lin, Niu, Stuart, Egginton, Shakil, Ahmad, Peter, Hewett, Christopher D, Kontos, Asif, Ahmed

Publikováno v: Cardiovascular Research

Aims Atherosclerosis is a chronic inflammatory disease occurring within the artery wall. A crucial step in atherogenesis is the infiltration and retention of monocytes into the subendothelial space of large arteries induced by chemokines and growth f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7577f0971ecd6ad8290df0bcee611ac5
https://pubmed.ncbi.nlm.nih.gov/28069704

NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis

Autor: Aleksandr E. Vendrov, Nageswara R. Madamanchi, Marschall S. Runge, Cedric Szyndralewiez, Patrick Page, Kimberly C. Molnar, Xi Lin Niu, Mason Runge

Publikováno v: Journal of Biological Chemistry. 285:26545-26557

The intracellular signaling events by which NADPH oxidase-generated reactive oxygen species (ROS) modulate vascular smooth muscle cell (VSMC) function and atherogenesis are yet to be entirely elucidated. We previously demonstrated that NADPH oxidase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7840473423be6f8eea0bd542af42f7
https://doi.org/10.1074/jbc.m110.143917

Leukocyte Antigen-related Protein Tyrosine Phosphatase Negatively Regulates Hydrogen Peroxide-induced Vascular Smooth Muscle Cell Apoptosis

Autor: Xi Lin Niu, Juxiang Li, Nageswara R. Madamanchi

Publikováno v: Journal of Biological Chemistry. 283:34260-34272

Reactive oxygen species (ROS) have been implicated in vascular smooth muscle cell (VSMC) apoptosis, a hallmark of advanced atherosclerotic lesions. Transient oxidation and inactivation of protein-tyrosine phosphatases play a critical role in cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504087be6e1fd893f564ced6094dc88d
https://doi.org/10.1074/jbc.m806087200

Does Oxidative DNA Damage Cause Atherosclerosis and Metabolic Syndrome?

Autor: Nageswara R. Madamanchi, Rui-Hai Zhou, Xi Lin Niu, Aleksandr E. Vendrov, Marschall S. Runge

Publikováno v: Circulation Research. 107:940-942

See related article, pages 1021–1031 The study of Mercer et al,1 published in this issue of Circulation Research , reports new evidence linking oxidative DNA damage, atherosclerosis, and the metabolic syndrome. Although these relationships have bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5587d22a13c27e5453922d88c3bc91ef
https://doi.org/10.1161/circresaha.110.230904

Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide

Autor: Christopher D. Kontos, Asif Ahmed, Jianhua Huang, Xi-Lin Niu, Peter W. Hewett, Rahul Potluri, Takeshi Fujisawa, Kunal Chudasama, Melissa J. Cudmore, Bahjat Al-Ani, Clarence M. Findley, Allyah Abbas, Shakil Ahmad, Vineet Bhandari, Gregory K.W. Lam

Publikováno v: Ahmed, A, Fujisawa, T, Niu, X-L, Ahmad, S, Al-Ani, B, Chudasama, K, Abbas, A, Potluri, R, Bhandari, V, Findley, C M, Lam, G K W, Huang, J, Hewett, P W, Cudmore, M & Kontos, C D 2009, ' Angiopoietin-2 confers Atheroprotection in apoE-/-mice by inhibiting LDL oxidation via nitric oxide ', Circulation Research, vol. 104, no. 12, pp. 1333-6 . https://doi.org/10.1161/CIRCRESAHA.109.196154

Atherosclerosis is promoted by a combination of hypercholesterolemia and vascular inflammation. The function of Angiopoietin (Ang)-2, a key regulator of angiogenesis, in the maintenance of large vessels is unknown. A single systemic administration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc634ace93834733e873aac054c0901c
https://pubmed.ncbi.nlm.nih.gov/19461044