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Akademický článek

Multi-omics-based investigation of Bifidobacterium’s inhibitory effect on glioma: regulation of tumor and gut microbiota, and MEK/ERK cascade

Autor: Huali Fan, Yuhan Wang, Mingyu Han, Li Wang, Xue Li, Xi Kuang, Junrong Du, Fu Peng

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

Glioma, the most prevalent primary tumor of the central nervous system, is characterized by a poor prognosis and a high recurrence rate. The interplay between microbes, such as gut and tumor microbiota, and the host has underscored the significant im

Externí odkaz: https://doaj.org/article/04355b70f57f4d16b2556d8b623a4fb3

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Akademický článek

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy

Autor: Meiyi Ge, Jian Luo, Yi Wu, Guobo Shen, Xi Kuang

Publikováno v: MedComm – Oncology, Vol 3, Iss 1, Pp n/a-n/a (2024)

Abstract Synthetic lethality (SL), a genetic concept, has revolutionized the development of antitumor therapies by providing avenues to target previously “undruggable” targets with enhanced specificity for tumor cells over normal tissue. The prin

Externí odkaz: https://doaj.org/article/d2fe79e35ee747f98e85a55ae349c464

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Akademický článek

Corticotropin releasing factor neurons in the visual cortex mediate long-term changes in visual function induced by early adversity

Autor: Yueqin Liu, Sitong Li, Xinxin Zhang, Laijian Wang, Ziming Li, Wei Wu, Xinya Qin, Jiangning Zhou, Chenchen Ma, Wei Meng, Xi Kuang, Fei Yin, Qianhui Xia, Bin Jiang, Yupeng Yang

Publikováno v: Neurobiology of Stress, Vol 21, Iss , Pp 100504- (2022)

Early adversity can cause malfunction of the visual system in adulthood. Adult female but not male mice undergoing early chronic mild stress (ECMS) maintain ocular dominance (OD) plasticity after the critical period. How early stressful experiences h

Externí odkaz: https://doaj.org/article/0d7a01ad169b44fdb3a0bcb7f33b5166

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Akademický článek

SPARC Knockdown Reduces Glutamate-Induced HT22 Hippocampal Nerve Cell Damage by Regulating Autophagy

Autor: Shuang Chen, Qin Zou, Qiang Guo, Yongmin Chen, Xi Kuang, Yukang Zhang, Yan Liu, Wengang Wu, Ge Li, Linzhi Tu, Jingyi Tong, Songrong Li, Lin Ma, Qifu Li

Publikováno v: Frontiers in Neuroscience, Vol 14 (2021)

Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein involved in the extracellular matrix and interactions between cells during neural development of the central nervous system (CNS). Oxidative glutamate toxicity is involve

Externí odkaz: https://doaj.org/article/1ac51bd9a1af44068e0dc893e3e4847e

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Akademický článek

Iron Metabolism and Ferroptosis in Epilepsy

Autor: Shuang Chen, Yongmin Chen, Yukang Zhang, Xi Kuang, Yan Liu, Meiwen Guo, Lin Ma, Daqi Zhang, Qifu Li

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Epilepsy is a disease characterized by recurrent, episodic, and transient central nervous system (CNS) dysfunction resulting from an excessive synchronous discharge of brain neurons. It is characterized by diverse etiology, complex pathogenesis, and

Externí odkaz: https://doaj.org/article/eef235c97aad49b7b204b4f7c6471ba7

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Akademický článek

Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling

Autor: Hong-Jing Zhou, Hui Li, Meng-Qi Shi, Xiao-Na Mao, Dong-Ling Liu, Yi-Ran Chang, Yu-Miao Gan, Xi Kuang, Jun-Rong Du

Publikováno v: Frontiers in Pharmacology, Vol 8 (2018)

Aging is the greatest independent risk factor for the occurrence of stroke and poor outcomes, at least partially through progressive increases in oxidative stress and inflammation with advanced age. Klotho is an antiaging gene, the expression of whic

Externí odkaz: https://doaj.org/article/09f2df0370c044aaac61a135cb4b251a

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Akademický článek

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

Autor: Xi Kuang, Hong-Jing Zhou, Amy H. Thorne, Xi-Nan Chen, Lin-Jiao Li, Jun-Rong Du

Publikováno v: Frontiers in Aging Neuroscience, Vol 9 (2017)

Emerging evidence suggests that alpha-processing single transmembrane proteins, amyloid precursor protein (APP) and anti-aging protein Klotho, are likely to be involved in the progression of Alzheimer’s disease (AD). The natural phthalide Ligustili

Externí odkaz: https://doaj.org/article/5569970dc273490cbb2204ccef3441d4

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Akademický článek

Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke.

Autor: Lu Yu, Chu Chen, Liang-Fen Wang, Xi Kuang, Ke Liu, Hao Zhang, Jun-Rong Du

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55839 (2013)

BackgroundIschemic brain injury is associated with neuroinflammatory response, which essentially involves glial activation and neutrophil infiltration. Transcription factors nuclear factor-κB (NF-κB) and signal transducer and activator of transcrip

Externí odkaz: https://doaj.org/article/e19cbb7e890c4af0b0c008a89ea3c79a

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The Behavioral Effects of Social Distance and Residual Claim Distribution on Budget Reporting in Hierarchical Organizations

Autor: Xi Kuang, Michael Majerczyk, Di Yang

Publikováno v: The Accounting Review. :1-16

We experimentally investigate how subordinates’ budget reporting in hierarchical organizations is influenced by social distance between subordinates and their direct manager. Although prior research promotes reducing this social distance to improve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::def0bac3a58afa2f8be89182f52105d8
https://doi.org/10.2308/tar-2021-0270

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