Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Xenxo Pérez-García"'
Autor:
Alejandro Carlos Curino, Norberto Ariel Gandini, Maria Marta Facchinetti, Yagamare Fall, Marcos L. Rivadulla, Generosa Gómez, Alejandro López Romero, María Eugenia Fermento, María Julia Ferronato, Débora Gisele Salomón, Manuel Pérez, Xenxo Pérez-García
Publikováno v:
Archiv der Pharmazie. 348:315-329
The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4870222a27f2e501ec038bf7df0be06
https://doi.org/10.1002/ardp.201400448
https://doi.org/10.1002/ardp.201400448
Publikováno v:
Current Topics in Medicinal Chemistry. 14:2388-2397
The Gemini analogs are the last significant contribution to the family of vitamin D derivatives in medicine, for the treatment of cancer. The first Gemini analog was characterized by two symmetric side chains at C-20. Following numerous modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd90b4fb854160432e721eceb471c22
https://doi.org/10.2174/1568026615666141208100411
https://doi.org/10.2174/1568026615666141208100411
Publikováno v:
Tetrahedron Letters. 50:4874-4877
Two new vitamin D2 analogues, (22Z)-25-(OH)-D2 and (22Z)-1α,25-(OH)2-D2, were serendipitously synthesized from vitamin D2 and using the Julia–Kocienski olefination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e28a1b9bb5b2ec23cff73313a9ae267
https://doi.org/10.1016/j.tetlet.2009.06.049
https://doi.org/10.1016/j.tetlet.2009.06.049
Publikováno v:
ChemInform. 46
The Gemini analogs are the last significant contribution to the family of vitamin D derivatives in medicine, for the treatment of cancer. The first Gemini analog was characterized by two symmetric side chains at C-20. Following numerous modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::169581e1889b6699579290ba329333c3
https://doi.org/10.1002/chin.201545250
https://doi.org/10.1002/chin.201545250
Autor:
María Julia, Ferronato, Débora Gisele, Salomón, María Eugenia, Fermento, Norberto Ariel, Gandini, Alejandro, López Romero, Marcos Lois, Rivadulla, Xenxo, Pérez-García, Generosa, Gómez, Manuel, Pérez, Yagamare, Fall, María Marta, Facchinetti, Alejandro Carlos, Curino
Publikováno v:
Archiv der Pharmazie. 348(5)
The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e55e54c834a6a006dcbc2870ba58de64
https://pubmed.ncbi.nlm.nih.gov/25864390
https://pubmed.ncbi.nlm.nih.gov/25864390
Publikováno v:
Tetrahedron Letters. 54:3164-3166
Vitamin D3 analogues with a nitrogen atom linked to C-25 have been synthesized. The key step involves an allylic substitution with 2-nitropropane using catalytic species of Pd(0). This optimized procedure gave the desired compound with complete regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b788ee14f01dc74a4e8e03ceb5735284
https://doi.org/10.1016/j.tetlet.2013.04.019
https://doi.org/10.1016/j.tetlet.2013.04.019
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 121:68-70
The synthesis of the clinically important drug calcipotriol (2, MC903) is described as an example of a new and efficient approach to C24-hydroxylated analogs and metabolites of vitamin D3 (1). The key step of the process is the generation of the C24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4849d3283a45dfb29d4adfee9e8541
https://doi.org/10.1016/j.jsbmb.2010.03.074
https://doi.org/10.1016/j.jsbmb.2010.03.074
Autor:
Shinji Hourai, Natacha Rochel, Dino Moras, Antonio Rumbo, Antonio Mouriño, Xenxo Pérez-García
Publikováno v:
Archives of Biochemistry and Biophysics
Archives of Biochemistry and Biophysics, Elsevier, 2007, 460 (2), pp.172-6. ⟨10.1016/j.abb.2007.01.031⟩
Archives of Biochemistry and Biophysics, Elsevier, 2007, 460 (2), pp.172-6. ⟨10.1016/j.abb.2007.01.031⟩
The crystal structures of vitamin D nuclear receptor (VDR) have revealed that all compounds are anchored by the same residues to the ligand binding pocket (LBP). Based on this observation, a synthetic analog with a locked side chain (21-nor-calcitrio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a320bbe322fd6043fc8bc6ac697877c
https://pubmed.ncbi.nlm.nih.gov/17346665
https://pubmed.ncbi.nlm.nih.gov/17346665
Autor:
Antonio Rumbo, María Jesús Larriba, Paloma Ordóñez, Antonio Mouriño, Xenxo Pérez-García, and Alberto Muñoz
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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instname
We describe the synthesis of the first locked side-chain analogues of the natural hormone 1α,25-(OH)2-D 3 and their effects on gene transcription in human colon cancer cells. Analogue 2 was more potent than 1α.25-(OH)2-D 3 at inducing vitamin D rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e674850d8c8d4286ca9bfa74148d2a3
http://hdl.handle.net/10261/80206
http://hdl.handle.net/10261/80206