Zobrazeno 1 - 10
of 439
pro vyhledávání: '"Xeno nucleic acid"'
Akademický článek
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Autor:
Camille Samson, Pierre Legrand, Mustafa Tekpinar, Jef Rozenski, Mikhail Abramov, Philipp Holliger, Vitor B. Pinheiro, Piet Herdewijn, Marc Delarue
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1647 (2020)
Archaeal DNA polymerases from the B-family (polB) have found essential applications in biotechnology. In addition, some of their variants can accept a wide range of modified nucleotides or xenobiotic nucleotides, such as 1,5-anhydrohexitol nucleic ac
Externí odkaz:
https://doaj.org/article/b095ac31ee974895994ea5dcc61f0c3a
Autor:
Fugang Li, Shangchun Sheng, Xi Zhou, Hongyan Yu, Guoming Xie, Ting Wang, Yujun Yang, Junjie Li, Qinli Pu
Publikováno v:
The Analyst. 146:6306-6314
Reliable and cost-effective quantification of RNA modifications at a specific gene locus is essential to elucidate the pathogenic mechanism encoded by RNA epigenetics. Current methods to quantify N6-methyladenosine (m6A) at specific sites can hardly
Autor:
Nithya Subramanian, Philipp Holliger, Benjamin T. Porebski, Gillian Houlihan, Alexander I. Taylor, Sebastian Arangundy-Franklin
Publikováno v:
Nature Chemistry. 12:683-690
The ability of reverse transcriptases (RTs) to synthesize a complementary DNA from natural RNA and a range of unnatural xeno nucleic acid (XNA) template chemistries, underpins key methods in molecular and synthetic genetics. However, RTs have proven
Publikováno v:
Viruses
Volume 13
Issue 10
bioRxiv
Viruses, Vol 13, Iss 1983, p 1983 (2021)
Volume 13
Issue 10
bioRxiv
Viruses, Vol 13, Iss 1983, p 1983 (2021)
The causative agent of COVID-19, SARS-CoV-2, gains access to cells through interactions of the receptor-binding domain (RBD) on the viral S protein with angiotensin-converting enzyme 2 (ACE2) on the surface of human host cells. Systematic evolution o
Autor:
Keiji Murayama, Hiroyuki Asanuma
Publikováno v:
Chembiochem : a European journal of chemical biology. 22(15)
Xeno nucleic acids (XNAs) are analogues of DNA and RNA that have a non-ribose artificial scaffold. XNAs are possible prebiotic genetic carriers as well as alternative genetic systems in artificial life. In addition, XNA oligomers can be used as biolo
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Evolution of xeno nucleic acid (XNA) world essentially requires template-directed synthesis of XNA polymers. In this study, we demonstrate template-directed synthesis of an acyclic XNA, acyclic l-threoninol nucleic acid (l-aTNA), via chemical ligatio
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Samson, Camille, Legrand, Pierre, Tekpinar, Mustafa, Rozenski, Jef, Abramov, Mikhail, Holliger, Philipp, Pinheiro, Vitor B, Herdewijn, Piet, Delarue, Marc
Publikováno v:
Biomolecules
Biomolecules, MDPI, 2020, 10 (12), pp.1647. ⟨10.3390/biom10121647⟩
Volume 10
Issue 12
Biomolecules, Vol 10, Iss 1647, p 1647 (2020)
Biomolecules, 2020, 10 (12), pp.1647. ⟨10.3390/biom10121647⟩
Biomolecules, MDPI, 2020, 10 (12), pp.1647. ⟨10.3390/biom10121647⟩
Volume 10
Issue 12
Biomolecules, Vol 10, Iss 1647, p 1647 (2020)
Biomolecules, 2020, 10 (12), pp.1647. ⟨10.3390/biom10121647⟩
Archaeal DNA polymerases from the B-family (polB) have found essential applications in biotechnology. In addition, some of their variants can accept a wide range of modified nucleotides or xenobiotic nucleotides, such as 1,5-anhydrohexitol nucleic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92df27c1d37945d4ec69db7615e219a4
https://lirias.kuleuven.be/handle/123456789/665277
https://lirias.kuleuven.be/handle/123456789/665277
Autor:
Mathy Froeyen, Ramanarayanan Krishnamurthy, Francesco De Riccardis, Tim C. Efthymiou, Piet Herdewijn, Matthias Stoop, Jesse V. Gavette
Publikováno v:
Chemistry – A European Journal. 24:12811-12819
The paradigm of homogenous-sugar-backbone of RNA and DNA has reliably guided the construction of many functional and useful xeno nucleic acid (XNA) systems to date. Deviations from this monotonous and canonical design, in many cases, results in oligo