Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Xenia Lojewski"'
Autor:
Marcel Naumann, Arun Pal, Anand Goswami, Xenia Lojewski, Julia Japtok, Anne Vehlow, Maximilian Naujock, René Günther, Mengmeng Jin, Nancy Stanslowsky, Peter Reinhardt, Jared Sterneckert, Marie Frickenhaus, Francisco Pan-Montojo, Erik Storkebaum, Ina Poser, Axel Freischmidt, Jochen H. Weishaupt, Karlheinz Holzmann, Dirk Troost, Albert C. Ludolph, Tobias M. Boeckers, Stefan Liebau, Susanne Petri, Nils Cordes, Anthony A. Hyman, Florian Wegner, Stephan W. Grill, Joachim Weis, Alexander Storch, Andreas Hermann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Abnormal cytoplasmic aggregates of FUS are a hallmark of some forms of amyotrophic lateral sclerosis (ALS). Here, using neurons derived from patients with FUS-ALS, the authors demonstrate that impairment of PARP-dependent DNA damage signaling is an e
Externí odkaz:
https://doaj.org/article/421d7fe19126448d9734fe819843c747
Autor:
Julia Japtok, Xenia Lojewski, Marcel Naumann, Moritz Klingenstein, Peter Reinhardt, Jared Sterneckert, Stefan Putz, Maria Demestre, Tobias M. Boeckers, Albert C. Ludolph, Stefan Liebau, Alexander Storch, Andreas Hermann
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 420-429 (2015)
Autosomal-dominant mutations within the gene FUS (fused in sarcoma) are responsible for 5% of familial cases of amyotrophic lateral sclerosis (ALS). The FUS protein is physiologically mainly located in the nucleus, while cytoplasmic FUS aggregates ar
Externí odkaz:
https://doaj.org/article/090bf0e93a484e199fd95ab2595c4dea
Autor:
Susanne Petri, Florian Wegner, Axel Freischmidt, Albert C. Ludolph, Peter Reinhardt, Arun Pal, Karlheinz Holzmann, Joachim Weis, Anthony A. Hyman, Anand Goswami, Andreas Hermann, Stephan W. Grill, Xenia Lojewski, Marcel Naumann, Anne Vehlow, Julia Japtok, Alexander Storch, Nils Cordes, Francisco Pan-Montojo, Dirk Troost, Mengmeng Jin, Jared Sterneckert, Ina Poser, René Günther, Tobias M. Boeckers, Jochen H. Weishaupt, Erik Storkebaum, Maximilian Naujock, Nancy Stanslowsky, Stefan Liebau, Marie Frickenhaus
Publikováno v:
Nature Communications 9, 335 (2018). doi:10.1038/s41467-017-02299-1
Nature Communications
Nature Communications 9(1), 335 (2018). doi:10.1038/s41467-017-02299-1
Nature communications, 9(1). Nature Publishing Group
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications 9(2018), 335
Nature Communications, 9, pp. 1-17
Nature Communications, 9, 1-17
Nature Communications
Nature Communications 9(1), 335 (2018). doi:10.1038/s41467-017-02299-1
Nature communications, 9(1). Nature Publishing Group
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications 9(2018), 335
Nature Communications, 9, pp. 1-17
Nature Communications, 9, 1-17
Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS. Proper shuttling between the nucleus and cytoplasm is essential for physiological cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e83528d7f7c7ee164b556332b6e9382
https://publications.rwth-aachen.de/record/757240
https://publications.rwth-aachen.de/record/757240
Autor:
Florian Wegner, Arun Pal, Xenia Lojewski, Peter Reinhardt, Susanne Petri, Jared Sterneckert, Philippe Corcia, Andreas Hermann, Nicole Kreiter, Maximilian Naujock, Alexander Storch
Publikováno v:
Neurobiology of Disease, Vol 115, Iss, Pp 167-181 (2018)
Neurobiology of disease 115, 167-181 (2018). doi:10.1016/j.nbd.2018.03.010
Neurobiology of disease 115, 167-181 (2018). doi:10.1016/j.nbd.2018.03.010
TAR DNA-binding protein 43 (TDP43) is a cause of familiar and sporadic amyotrophic lateral sclerosis (ALS). The diverse postulated mechanisms by which TDP43 mutations cause the disease are not fully understood. Human wildtype and TDP43 S393L and G294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f38608e9ff35eea6064a5849b323060
https://doi.org/10.1101/218610
https://doi.org/10.1101/218610
Autor:
Albert C. Ludolph, Tobias M. Boeckers, Stefan Liebau, Moritz Klingenstein, Julia Japtok, Stefan Putz, Xenia Lojewski, Marcel Naumann, Alexander Storch, Jared Sterneckert, Peter Reinhardt, Andreas Hermann, Maria Demestre
Publikováno v:
Neurobiology of Disease, Vol 82, Iss, Pp 420-429 (2015)
Neurobiology of disease 82, 420-429 (2015). doi:10.1016/j.nbd.2015.07.017
Neurobiology of disease 82, 420-429 (2015). doi:10.1016/j.nbd.2015.07.017
Autosomal-dominant mutations within the gene FUS (fused in sarcoma) are responsible for 5% of familial cases of amyotrophic lateral sclerosis (ALS). The FUS protein is physiologically mainly located in the nucleus, while cytoplasmic FUS aggregates ar
Autor:
Johannes Schwarz, Susanne Hallmeyer-Elgner, Juliane Rauh, Verdon Taylor, Silvan Francke, Marcos J. Araúzo-Bravo, Matthias Kirsch, Alexander Storch, Sumitra Srimasorn, Andreas Hermann, Manja Wobus, Sigrid C. Schwarz, Xenia Lojewski
Publikováno v:
Stem cells translational medicine 4(10), 1223-1233 (2015). doi:10.5966/sctm.2015-0057
STEM CELLS TRANSLATIONAL MEDICINE
STEM CELLS TRANSLATIONAL MEDICINE
Brain perivascular cells have recently been identified as a novel mesodermal cell type in the human brain. These cells reside in the perivascular niche and were shown to have mesodermal and, to a lesser extent, tissue-specific differentiation potenti
Autor:
Susanne Hallmeyer-Elgner, Matthias Kirsch, Hans R. Schöler, Alexander Storch, Johannes Schwarz, Andreas Hermann, Xenia Lojewski, Marcos J. Araúzo-Bravo, Florian Wegner
Publikováno v:
Stem cells translational medicine 3(4), 458-469 (2014). doi:10.5966/sctm.2013-0117
Adult neural progenitor cells (aNPC) are a potential autologous cell source for cell replacement in neurologic diseases or for cell-based gene therapy of neurometabolic diseases. Easy accessibility, long-term expandability, and detailed characterizat
Autor:
Carsten Drepper, Xenia Lojewski, Rajeeve Sivadasan, Anna Hansel, Michael Sendtner, Daniel Hornburg, Jared Sterneckert, Andreas Hermann, Felix Meissner, Pamela J. Shaw, Sibylle Jablonka, Nicolas Frank, Matthias Mann, Paul G. Ince
Publikováno v:
Nature reviews / Neuroscience 19(12), 1610-1618 (2016). doi:10.1038/nn.4407
Intronic hexanucleotide expansions in C9ORF72 are common in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, but it is unknown whether loss of function, toxicity by the expanded RNA or dipeptides from non-ATG-initiated translation are
Autor:
Maximilian Naujock, Stefan Liebau, Florian Wegner, Marie Frickenhaus, Moritz Klingenstein, Tobias M. Boeckers, Albert C. Ludolph, Ekaterini Kefalakes, Maria Demestre, Marcel Naumann, Alexander Storch, Stefan Putz, Nancy Stanslowsky, Franziska Bursch, Andreas Hermann, Reinhard Dengler, Kwang-Soo Kim, Susanne Petri, Sebastian Bufler, Xenia Lojewski, Jared Sterneckert, Peter Reinhardt, Carola Kassebaum
Publikováno v:
Stem cells 34(6), 1563-1575 (2016). doi:10.1002/stem.2354
Despite decades of research on amyotrophic lateral sclerosis (ALS), there is only one approved drug, which minimally extends patient survival. Here, we investigated pathophysiological mechanisms underlying ALS using motor neurons (MNs) differentiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e6d415d7ea6d1e7ff503f00ac0df44
Autor:
Diane Lucente, Stephen J. Haggarty, Uma Chandrachud, John F. Staropoli, Ronald G. Crystal, Hans R. Schöler, Kendrick A. Goss, Anton Petcherski, Dolan Sondhi, Steven D. Sheridan, Andreas Hermann, Susan L. Cotman, Xenia Lojewski, Sunita Biswas-Legrand, Martin K. Selig, Katherine B. Sims, James F. Gusella, Alexander Storch, Scott H. Coppel, Larissa Haliw, Jared Sterneckert, Peter Reinhardt, Alexandra M. Simas
Publikováno v:
Human molecular genetics 23(8), 2005-2022 (2013). doi:10.1093/hmg/ddt596
Neuronal ceroid lipofuscinosis (NCL) comprises ∼13 genetically distinct lysosomal disorders primarily affecting the central nervous system. Here we report successful reprograming of patient fibroblasts into induced pluripotent stem cells (iPSCs) fo