Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Xenia B, Searle"'
Autor:
C. Tse, Ying Jia, X. Wang, Liu Bo, Douglas M. Cyr, Torben R. Neelands, Wenqing Gao, Xenia B. Searle, Ashvani K. Singh, Timothy A. Vortherms, Hong Y. Ren, Andrew M. Swensen, Corina Balut, Arlene M. Manelli, Sara Alani, Philip R. Kym, K. Conrath, Tzyh Chang Hwang, Yihong Fan
Publikováno v:
J Pharmacol Exp Ther
Cystic fibrosis (CF) is the most common monogenic autosomal recessive disease in Caucasians caused by pathogenic mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (CFTR). Significant small molecule therapeutic advances
Autor:
Marc J C, Scanio, Xenia B, Searle, Bo, Liu, John R, Koenig, Robert J, Altenbach, Gregory A, Gfesser, Andrew, Bogdan, Stephen, Greszler, Gang, Zhao, Ashvani, Singh, Yihong, Fan, Andrew M, Swensen, Timothy, Vortherms, Arlene, Manelli, Corina, Balut, Wenqing, Gao, Hong, Yong, Michael, Schrimpf, Chris, Tse, Philip, Kym, Xueqing, Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128843
Cystic fibrosis (CF) is an autosomal recessive disease resulting from mutations on both copies of the CFTR gene. Phenylalanine deletion at position 508 of the CFTR protein (F508del-CFTR) is the most frequent mutation in CF patients. Currently, the mo
Autor:
A. M. Manelli, Y. Jia, Philip R. Kym, X. Wang, Timothy A. Vortherms, S. Alani, Wenqing Gao, C. Balut, Ashvani K. Singh, Tzyh Chang Hwang, Douglas M. Cyr, H. Y. Ren, Andrew M. Swensen, Y. Fan, Torben R. Neelands, K. Conrath, C. Tse, Xenia B. Searle, Liu Bo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 374(3)
Publikováno v:
The Journal of organic chemistry. 85(11)
A scalable
Autor:
Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
Publikováno v:
Chemical Biology & Drug Design. 69:395-404
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein targets uniquely found in bacteria
Autor:
Patel Jyoti R, Fan Yang, Richard A. Craig, Jieyi Wang, Pingping Lou, Ki H. Kim, Chang Park, Scott A. Erickson, George S. Sheppard, Megumi Kawai, Linda Lynch, Nwe Y. Bamaung, Xenia B. Searle, Jack Henkin, Richard R. Lesniewski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:865-868
Substituted 3-amino-2-hydroxyamides and related hydroxyamides and acylhydrazines were identified as inhibitors of human methionine aminopeptidase-2 (MetAP2). Examination of substituents through parallel synthesis and iterative structure-based design