Semantic text mining in early drug discovery for type 2 diabetes.

Autor: Lena K Hansson, Rasmus Borup Hansen, Sune Pletscher-Frankild, Rudolfs Berzins, Daniel Hvidberg Hansen, Dennis Madsen, Sten B Christensen, Malene Revsbech Christiansen, Ulrika Boulund, Xenia Asbæk Wolf, Sonny Kim Kjærulff, Martijn van de Bunt, Søren Tulin, Thomas Skøt Jensen, Rasmus Wernersson, Jan Nygaard Jensen

Publikováno v: PLoS ONE, Vol 15, Iss 6, p e0233956 (2020)

BackgroundSurveying the scientific literature is an important part of early drug discovery; and with the ever-increasing amount of biomedical publications it is imperative to focus on the most interesting articles. Here we present a project that high

Externí odkaz: https://doaj.org/article/97287a9d68b2414aad61ea290a973c33

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

Autor: Rasmus Wernersson, Fredrik Wolfhagen Sand, Charlotte Helgstrand, Kevin Dalgaard, Jacob Hald, Anne Grapin-Botton, Sven Hastrup, Thomas Frogne, Jonas Ahnfelt-Rønne, Ole D. Madsen, Lena Hansson, Erik Vernet, Mark Kalisz, Dennis Madsen, Tomas Alanentalo, Mads Grønborg, Maja Borup Kjær Petersen, Fredrik Kryh Öberg, Michael Paolo Bastner Sandrini, Annette Plesner, Claude Rescan, Christian Honoré, Philippe Ravassard, Carsten Jessen, Louise Winkel, Camilla Ingvorsen, Xenia Asbæk Wolf, Hanni Willenbrock, Jan N. Jensen, Anna Kirstine Ringgaard, Christine Bruun, Violeta Georgieva Tsonkova, Jacob Hecksher-Sørensen, Johannes Josef Fels, Lars Groth Grunnet, Allan Christian Shaw

Publikováno v: Molecular metabolism
Molecular metabolism, Elsevier, 2018, 8, pp.144-157. ⟨10.1016/j.molmet.2017.12.007⟩
Molecular Metabolism
Molecular Metabolism, Vol 8, Iss, Pp 144-157 (2018)
Tsonkova, V G, Sand, F W, Wolf, X A, Grunnet, L G, Ringgaard, A K, Ingvorsen, C, Winkel, L, Kalisz, M, Dalgaard, K, Bruun, C, Fels, J J, Helgstrand, C, Hastrup, S, Öberg, F K, Vernet, E, Sandrini, M P B, Shaw, A C, Jessen, C, Grønborg, M, Hald, J, Willenbrock, H, Madsen, D, Wernersson, R, Hansson, L, Jensen, J N, Plesner, A, Alanentalo, T, Petersen, M B K, Grapin-Botton, A, Honoré, C, Ahnfelt-Rønne, J, Hecksher-Sørensen, J, Ravassard, P, Madsen, O D, Rescan, C & Frogne, T 2018, ' The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates ', Molecular Metabolism, vol. 8, pp. 144-157 . https://doi.org/10.1016/j.molmet.2017.12.007

Objective To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a screen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb3e641ee305f9db5f81e09f4ed88e7
https://hal.sorbonne-universite.fr/hal-02018209/document

Three-dimensional localisation of NANOG OCT4 and E-CADHERIN in porcine pre- and peri-implantation embryos

Autor: Poul Hyttel, Xenia Asbæk Wolf, Palle Serup

Publikováno v: Developmental Dynamics; Vol 240
Developmental Dynamics

The expression patterns of NANOG and OCT4 have previously been reported to differ markedly between mammalian species indicating distinct species-specific roles during development. We investigate the three-dimensional expression pattern of NANOG and O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0334780e3641acf044dce4accbb33e7

15-P030 Embryo patterning in gastrulating pig and mouse embryos

Autor: Palle Serup, Xenia Asbæk Wolf, Poul Maddox-Hyttel

Publikováno v: Mechanisms of Development. 126

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab2e1990ec6cac8df5d4cc83f61eadb