Structural insights into the role and targeting of EGFRvIII

Autor: Bagchi, Atrish, Stayrook, Steven E., Xenaki, Katerina T., Starbird, Chrystal A., Doulkeridou, Sofia, el Khoulati, Rachid, Roovers, Rob C., Schmitz, Karl R., van Bergen en Henegouwen, Paul M.P., Ferguson, Kathryn M.

Publikováno v: In Structure 5 September 2024 32(9):1367-1380

Site‐specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9

Autor: Neviani, Viviana, van Deventer, Sjoerd, Wörner, Tobias P, Xenaki, Katerina T, van de Waterbeemd, Michiel, Rodenburg, Remco N P, Wortel, Inge M N, Kuiper, Jeroen K, Huisman, Sofie, Granneman, Joke, van Bergen En Henegouwen, Paul M P, Heck, Albert J R, van Spriel, Annemiek B, Gros, Piet, Sub Crystal and Structural Chemistry, Sub Biomol.Mass Spectrometry & Proteom., Sub Cell Biology, Afd Biomol.Mass Spect. and Proteomics, Crystal and Structural Chemistry, Biomolecular Mass Spectrometry and Proteomics, Celbiologie

Publikováno v: The Febs Journal
The FEBS journal, 287(24), 5323. Blackwell Publishing Ltd
The FEBS Journal
FEBS Journal, 287, 5323-5344
FEBS Journal, 287, 24, pp. 5323-5344

Lipidation of transmembrane proteins regulates many cellular activities, including signal transduction, cell–cell communication, and membrane trafficking. However, how lipidation at different sites in a membrane protein affects structure and functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7facc787183d30e3d7ae754ff4f7fbe1
http://europepmc.org/articles/PMC7818406

Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in mice

Autor: Xenaki, Katerina T, Dorrestijn, Bram, Muns, Joey A, Adamzek, Kevin, Doulkeridou, Sofia, Houthoff, HendrikJan, Oliveira, Sabrina, van Bergen En Henegouwen, Paul Mp, Sub Cell Biology, Afd Pharmaceutics, Celbiologie, Pharmaceutics

Publikováno v: Theranostics
Theranostics, 11(11), 5525. Ivyspring International Publisher

Background: The non-homogenous distribution of antibody-drug conjugates (ADCs) within solid tumors is a major limiting factor for their wide clinical application. Nanobodies have been shown to rapidly penetrate into xenografts, achieving more homogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe9464d9b902b528791274dd58b739a
https://pubmed.ncbi.nlm.nih.gov/33859761

Dual Targeting of Endothelial and Cancer Cells Potentiates In Vitro Nanobody-Targeted Photodynamic Therapy

Autor: Mashayekhi, Vida, Xenaki, Katerina T, van Bergen En Henegouwen, Paul M P, Oliveira, Sabrina, Sub Cell Biology, Afd Pharmaceutics, Celbiologie, Pharmaceutics

Publikováno v: Cancers
Cancers, Vol 12, Iss 2732, p 2732 (2020)
Cancers, 12(10). Multidisciplinary Digital Publishing Institute (MDPI)
Volume 12
Issue 10

Simple Summary Photodynamic therapy (PDT) eradicates tumors by the local activation of a photosensitizer with appropriate light. Although very promising, its clinical application is limited by the sub-optimal tumor specificity of the photosensitizer.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bac73a943cb6d8c6ca30f361a904ccb

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