Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Xenón Serrano"'
Autor:
Ali Mijoba, Nereida Parra-Giménez, Esteban Fernandez-Moreira, Hegira Ramírez, Xenón Serrano, Zuleima Blanco, Sandra Espinosa, Jaime E. Charris
Publikováno v:
Molecules, Vol 29, Iss 17, p 4125 (2024)
The aim of this work was to obtain and evaluate, as antiprotozoals, new derivatives of benzoate imidazo-1,3,4-thiadiazole 18–23 based on the concepts of molecular repositioning and hybridization. In the design of these compounds, two important phar
Externí odkaz:
https://doaj.org/article/4901eeef606e4e658bea1f27556d6878
Autor:
Zuleima Blanco, Esteban Fernandez-Moreira, Michael R. Mijares, Carmen Celis, Gricelis Martínez, Juan B. De Sanctis, Soňa Gurská, Petr Džubák, Marián Hajdůch, Ali Mijoba, Yael García, Xenón Serrano, Nahum Herrera, Jhonny Correa-Abril, Yonathan Parra, Jorge Ángel, Hegira Ramírez, Jaime E. Charris
Publikováno v:
Molecules, Vol 27, Iss 17, p 5626 (2022)
The coexistence of leishmaniasis, Chagas disease, and neoplasia in endemic areas has been extensively documented. The use of common drugs in the treatment of these pathologies invites us to search for new molecules with these characteristics. In this
Externí odkaz:
https://doaj.org/article/2f9fecb0b6884c4cb8a3b7f2b739e2f1
Publikováno v:
Proceedings of 7th International Electronic Conference on Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e888402a5af46ab0a2da0249e82544a8
https://doi.org/10.3390/ecmc2021-11546
https://doi.org/10.3390/ecmc2021-11546
Autor:
Jacques Leañez, Jorge Vega NuñEz, Josue S. Bello Forero, Felipe Sojo, Alvaro Alvarez-Aular, Vladimir V. Kouznetsov, Yael García-Marchan, Francisco Arvelo, Daniel Rodriguez, Ignacio Buscema, Xenón Serrano-Martín
Publikováno v:
Experimental parasitology. 198
Diverse spiro dihydroquinoline-oxindoles (JS series) were prepared using the BF3•OEt2-catalyzed imino Diels-Alder reaction between ketimine-isatin derivatives and trans-isoeugenol. Ten spiro-oxiindole derivatives were selected and evaluated at diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ed11c40cbae4dadc0cbd4af205e282
https://pubmed.ncbi.nlm.nih.gov/30690024
https://pubmed.ncbi.nlm.nih.gov/30690024
Autor:
Gustavo Benaim, Xenón Serrano-Martín, Andrea Pinto-Martinez, Jessica Rodríguez-Durán, Vanessa Hernandez-Rodriguez
Leishmania donovani is the causing agent of visceral leishmaniasis, a common infection that affects millions of people from the most underdeveloped countries. Miltefosine is the only oral drug to treat infections caused by L. donovani . Nevertheless,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6f0ea240c0c016ff44474ade9d3ba3
https://europepmc.org/articles/PMC5740361/
https://europepmc.org/articles/PMC5740361/
Autor:
Simón E. López, Rafael Medina, Ali Mijoba, Jorge Núñez-Durán, Yael García-Marchan, Jacques Leañez, Xenón Serrano-Martín, Angel H. Romero, Anamaría Alcala, Carlos Ciangherotti
Publikováno v:
European journal of medicinal chemistry. 127
With the aim to identify a potential drug candidate to treat cutaneous leishmaniasis, a series of 1-phthalazinyl hydrazones were synthesized and tested against Leishmania braziliensis parasite, one of the main responsible of this disease in the world
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e3b032757fd0d7cdc6d6c9d1f00fdb
https://pubmed.ncbi.nlm.nih.gov/28119201
https://pubmed.ncbi.nlm.nih.gov/28119201
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:4214-4216
Glibenclamide reduced the rate of lesion growth in BALB/c mice infected with Leishmania ( Leishmania ) mexicana , the effect was dose dependent, and the highest dose proved more effective than glucantime. Cross-resistance to glucantime was found in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79eb007637e61022fea0f6feeb2082e
https://doi.org/10.1128/aac.00617-06
https://doi.org/10.1128/aac.00617-06
Autor:
Yael García-Marchan, Vladimir V. Kouznetsov, Daniel Rodriguez, Xenón Serrano-Martín, Daznia Bompart, Jorge Núñez-Durán, Gonzalo Visbal, Carlos M. Meléndez Gómez, Francisco Arvelo, Felipe Sojo, Alvaro Alvarez
Publikováno v:
Bioorganicmedicinal chemistry. 21(14)
A series of diverse simple C2-aryl quinolines was synthesized de novo via a straightforward synthesis based on the acid-catalyzed multicomponent imino Diels-Alder reactions. Seven selected quinolines were evaluated at different stages of Leishmania b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3179b1232e4af229a3ffd14218f2f0
https://pubmed.ncbi.nlm.nih.gov/23719286
https://pubmed.ncbi.nlm.nih.gov/23719286
Autor:
Juan Carlos Martínez, Alexis Mendoza-León, Gilberto Payares, Gustavo Benaim, Xenón Serrano-Martín, Marisel De Lucca
Leishmaniasis is parasitic disease that is an important problem of public health worldwide. Intramuscularly administered glucantime and pentostam are the most common drugs used for treatment of this disease, but they have significant limitations due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4741e8054e4c9e6dc8fb96d0dbeb8062
https://europepmc.org/articles/PMC2786335/
https://europepmc.org/articles/PMC2786335/
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