Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223

Autor: Xavier de Mollerat du Jeu, Casey D. Johnson, Nektaria Adronikou, Yun Chin Lin, Hana del Pilar, Josh Boyer, Ariel E. Feldstein, Cristina Llorente, Masahiko Tameda, Carolina Jimenez Calvente

Publikováno v: Journal of Clinical Investigation. 129:4091-4109

Persistent, unresolved inflammation in the liver represents a key trigger for hepatic injury and fibrosis in various liver diseases and is controlled by classically activated pro-inflammatory macrophages, while restorative macrophages of the liver ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe452841fe6ca882dcf0a5873dc3aee
https://doi.org/10.1172/jci122258

Liposome based systems for systemic siRNA delivery: Stability in blood sets the requirements for optimal carrier design

Autor: Xavier de Mollerat du Jeu, Liesbeth Peeters, Katarina Farkasova, Rupa R. Sawant, Niek N. Sanders, Joseph Demeester, Stefaan C. De Smedt, Vladimir P. Torchilin, Manfred Ogris, Kevin Braeckmans, Leo A. van Grunsven, Kevin Buyens

Publikováno v: Vrije Universiteit Brussel

siRNA therapeutics are currently regarded as promising candidates to make a leap forward in the search for treatments of various hard to cure diseases. In order to exploit the full potential of siRNA based therapeutics, development of delivery system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2549cc30012e2a9c656f8b9baf4f1410
https://doi.org/10.1016/j.jconrel.2011.10.009

Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity

Autor: Frédéric Gachon, Walter Wahli, Thierry Claudel, Nicolas Leuenberger, Ueli Schibler, Xavier de Mollerat du Jeu, Céline Jouffe, Fabienne Fleury Olela, Pascal Gos

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 12, pp. 4794-4799

In mammals, many aspects of metabolism are under circadian control. At least in part, this regulation is achieved by core-clock or clock-controlled transcription factors whose abundance and/or activity oscillate during the day. The clock-controlled p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755939671848e03eeb4eb432e82f34cd

Liver Bid-suppression for treatment of fibrosis associated with nonalcoholic steatohepatitis

Autor: Andronikou Nektaria, Xavier de Mollerat du Jeu, Ariel E. Feldstein, Casey D. Johnson, Akiko Eguchi

Publikováno v: Journal of hepatology, vol 64, iss 3

Background & Aims Liver fibrosis is the most worrisome feature of non-alcoholic steatohepatitis (NASH). Growing evidence supports a link between hepatocyte apoptosis and liver fibrogenesis. Our aim was to determine the therapeutic efficacy and safety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481365aeed0ec944e78cc0a5ca0d2eed
https://europepmc.org/articles/PMC4761314/

462. Serum Free Clinical Grade Large Scale Lentiviral Production System for Gene Therapy Application

Autor: Xavier de Mollerat du Jeu, Xin Yu, Mu Li

Publikováno v: Molecular Therapy. 24:S183

Recently, lentiviral vectors have become the center of attention for its use as gene transfer vectors in gene therapy. Current new generation of therapies CAR - T requires the lentiviral vectors as efficient gene transfer tool to express engineered C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3728b6be1a191c54ad88f183c77c6993
https://doi.org/10.1016/s1525-0016(16)33271-3