Thiol starvation triggers melanoma state switching in an ATF4 and NRF2-dependent manner.

Autor: Meinert M; Department of Physiological Chemistry, University of Würzburg, Würzburg, Germany., Jessen C; Institute of Pathology, University of Würzburg, Würzburg, Germany., Hufnagel A; Institute of Pathology, University of Würzburg, Würzburg, Germany., Kreß JKC; Institute of Pathology, University of Würzburg, Würzburg, Germany., Burnworth M; Institute of Pathology, University of Würzburg, Würzburg, Germany., Däubler T; Institute of Pathology, University of Würzburg, Würzburg, Germany., Gallasch T; Institute of Pathology, University of Würzburg, Würzburg, Germany., Xavier da Silva TN; Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Dos Santos AF; Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Ade CP; Department of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany., Schmitz W; Department of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany., Kneitz S; Department of Biochemistry and Cell Biology, University of Würzburg, Würzburg, Germany., Friedmann Angeli JP; Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Meierjohann S; Department of Physiological Chemistry, University of Würzburg, Würzburg, Germany; Institute of Pathology, University of Würzburg, Würzburg, Germany; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany. Electronic address: svenja.meierjohann@uni-wuerzburg.de.

Publikováno v: Redox biology [Redox Biol] 2024 Apr; Vol. 70, pp. 103011. Date of Electronic Publication: 2023 Dec 27.

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.

Autor: Freitas FP; Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Alborzinia H; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Dos Santos AF; Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Nepachalovich P; Center of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany., Pedrera L; Institute of Genetics, CECAD, University of Cologne, Cologne, Germany., Zilka O; Department of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada., Inague A; Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.; Instituto de Química, Universidade de Sao Paulo, Sao Paulo, Brazil., Klein C; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Aroua N; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Kaushal K; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Kast B; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Lorenz SM; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany., Kunz V; Comprehensive Cancer Center Mainfranken, Universitätsklinikum Würzburg, Würzburg, Germany., Nehring H; Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Xavier da Silva TN; Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Chen Z; Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Atici S; Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Doll SG; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany., Schaefer EL; Department of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada., Ekpo I; Department of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada., Schmitz W; Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany., Horling A; Institute of Pharmacy, Martin Luther University Halle Wittenberg, Halle, Germany., Imming P; Institute of Pharmacy, Martin Luther University Halle Wittenberg, Halle, Germany., Miyamoto S; Instituto de Química, Universidade de Sao Paulo, Sao Paulo, Brazil., Wehman AM; Department of Biological Sciences, University of Denver, Denver, CO, USA., Genaro-Mattos TC; Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE, USA., Mirnics K; Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE, USA., Kumar L; Faculty of Applied Sciences and Biotechnology, Shoolini University, Himachal Pradesh, India., Klein-Seetharaman J; Department of Physics, Colorado School of Mines, Golden, CO, USA.; School of Molecular Sciences, Arizona State University, Phoenix, AZ, USA., Meierjohann S; Department of Pathology, University of Würzburg, Würzburg, Germany., Weigand I; Medizinische Klinik und Poliklinik IV, Ludwig Maximillian University, Munich, Germany., Kroiss M; Medizinische Klinik und Poliklinik IV, Ludwig Maximillian University, Munich, Germany., Bornkamm GW; Institute of Experimental Cancer Research, University Hospital Ulm, Ulm, Germany., Gomes F; Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil., Netto LES; Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil., Sathian MB; Department of Pharmacy, Ludwig Maximilian University of Munich, Munich, Germany., Konrad DB; Department of Pharmacy, Ludwig Maximilian University of Munich, Munich, Germany., Covey DF; Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO, USA.; Taylor Family Institute for Innovative Psychiatric Research, Washington University, St. Louis, MO, USA., Michalke B; Research Unit Analytical BioGeoChemistry, Helmholtz Center München (HMGU), Neuherberg, Germany., Bommert K; Comprehensive Cancer Center Mainfranken, Universitätsklinikum Würzburg, Würzburg, Germany., Bargou RC; Comprehensive Cancer Center Mainfranken, Universitätsklinikum Würzburg, Würzburg, Germany., Garcia-Saez A; Institute of Genetics, CECAD, University of Cologne, Cologne, Germany., Pratt DA; Department of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada., Fedorova M; Center of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany., Trumpp A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany., Friedmann Angeli JP; Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany. pedro.angeli@uni-wuerzburg.de.

Publikováno v: Nature [Nature] 2024 Feb; Vol. 626 (7998), pp. 401-410. Date of Electronic Publication: 2024 Jan 31.

Sabotaging the breaks: FSEN1 expands the toolbox of FSP1 inhibitors.

Autor: Xavier da Silva TN; Rudolf Virchow Center for Integrative and Translational Bioimaging, Chair of Translational Cell Biology, University of Wuerzburg, 97080 Wuerzburg, Germany., Friedmann Angeli JP; Rudolf Virchow Center for Integrative and Translational Bioimaging, Chair of Translational Cell Biology, University of Wuerzburg, 97080 Wuerzburg, Germany. Electronic address: pedro.angeli@virchow.uni-wuerzburg.de.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2023 Sep 21; Vol. 30 (9), pp. 1006-1008.

The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2.

Autor: Kreß JKC; Institute of Pathology, University of Würzburg, 97080 Würzburg, Germany., Jessen C; Institute of Pathology, University of Würzburg, 97080 Würzburg, Germany., Hufnagel A; Institute of Pathology, University of Würzburg, 97080 Würzburg, Germany., Schmitz W; Department of Biochemistry and Molecular Biology, University of Würzburg, 97074 Würzburg, Germany., Xavier da Silva TN; Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany., Ferreira Dos Santos A; Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany., Mosteo L; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, 4200-135 Porto, Portugal., Goding CR; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK., Friedmann Angeli JP; Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany., Meierjohann S; Institute of Pathology, University of Würzburg, 97080 Würzburg, Germany; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, 97080 Würzburg, Germany. Electronic address: svenja.meierjohann@uni-wuerzburg.de.

Publikováno v: Cell reports [Cell Rep] 2023 Jul 25; Vol. 42 (7), pp. 112724. Date of Electronic Publication: 2023 Jul 04.

Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals.

Autor: Barayeu U; Division of Redox Regulation, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Schilling D; Division of Redox Regulation, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Eid M; Division of Redox Regulation, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Xavier da Silva TN; Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Schlicker L; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany., Mitreska N; Department of Biophysics, Faculty of Medicine, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Zapp C; Molecular Biomechanics, Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany.; Institute for Theoretical Physics, Heidelberg University, Heidelberg, Germany., Gräter F; Molecular Biomechanics, Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany., Miller AK; Research Group Cancer Drug Development, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kappl R; Department of Biophysics, Faculty of Medicine, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Schulze A; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Friedmann Angeli JP; Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Dick TP; Division of Redox Regulation, German Cancer Research Center (DKFZ), Heidelberg, Germany. t.dick@dkfz.de.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany. t.dick@dkfz.de.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2023 Jan; Vol. 19 (1), pp. 28-37. Date of Electronic Publication: 2022 Sep 15.