Výsledky vyhledávání - "Xavier Z. Khawaja"

Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission

Autor: James J. Crowley, Jessica E. Malberg, Xavier Z. Khawaja, Tiffany I. Hill, Brian A. Hoshaw, Sharon Rosenzweig-Lipson, Lee E. Schechter, Irwin Lucki

Publikováno v: European Journal of Pharmacology. 594:109-116

Previous research has suggested that mobilization of neurotrophic factors, such as insulin-like growth factor I (IGF-I), can be involved in the effects of antidepressant treatments. The current experiments showed that IGF-I leads to antidepressant-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d9abb502a15d79a16559cfb71247e6
https://doi.org/10.1016/j.ejphar.2008.07.023

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Differentiating antidepressants of the future: Efficacy and safety

Autor: Lee E. Schechter, Xavier Z. Khawaja, Sharon Rosenzweig-Lipson, Robert H. Ring, Zia Ur Rahman, Zoë A. Hughes, Somana J. Rajarao, Chad E. Beyer, Jessica E. Malberg

Publikováno v: Pharmacology & Therapeutics. 113:134-153

There have been significant advances in the treatment of depression since the serendipitous discovery that modulating monoaminergic neurotransmission may be a pathological underpinning of the disease. Despite these advances, particularly over the las

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441c2a170683457931a1eb3c7319ea62
https://doi.org/10.1016/j.pharmthera.2006.07.002

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WAY-100635 antagonist-induced plasticity of 5-HT1A receptors: regulatory differences between a stable cell line and an in vivo native system

Autor: Deborah L. Smith, Daniel Wayne Dilks, Jean Zhang, Michael A. Olsen, Xavier Z. Khawaja, Stanley P. Nawoschik, John Dunlop, Lee E. Schechter

Publikováno v: Journal of Neurochemistry. 98:134-145

We present evidence that the 5-hydroxytryptamine1A (5-HT1A) receptor antagonist, N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl}-N-(2-pyridinyl)cyclohexanecarboxamide (WAY-100635), can induce receptor internalization in a human (h)5-HT1A receptor Chi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8d4470c31a8914eb507b65765195b40
https://doi.org/10.1111/j.1471-4159.2006.03883.x

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Innovative approaches for the development of antidepressant drugs: Current and future strategies

Autor: Chad E. Beyer, Sharon Rosenzweig-Lipson, Robert H. Ring, Lee E. Schechter, Jessica E. Malberg, Xavier Z. Khawaja, Zoë A. Hughes

Publikováno v: NeuroRX. 2:590-611

Summary: Depression is a highly debilitating disorder that has been estimated to affect up to 21% of the world population. Despite the advances in the treatment of depression with selective serotonin reuptake inhibitors (SSRIs) and serotonin and nore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d034a63e30b20b55ee82748d5bcda657
https://doi.org/10.1602/neurorx.2.4.590

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Basal adrenocorticotropin (ACTH) secretion is negatively modulated by protein phosphatase 5 in mouse pituitary corticotropin AtT20 cells

Autor: Feng Liu, Xavier Z. Khawaja

Publikováno v: Regulatory Peptides. 127:191-196

siRNA oligonucleotides for protein phosphatase 5 (PP5) were designed and transfected into mouse corticotroph AtT20 cells to induce lower PP5 expression levels. PP5-siRNA transfections (at 3 days) produced a approximately 50% down-regulation in target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1331c1c23d75f5a4e3c55e74f1b24869
https://doi.org/10.1016/j.regpep.2004.12.020

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Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: Implications for depressive disorders and future therapies

Autor: James E. Barrett, Jun Xu, Jin-Jun Liang, Xavier Z. Khawaja

Publikováno v: Journal of Neuroscience Research. 75:451-460

It is recognized that monoamine reuptake inhibitors (MARIs) exert beneficial effects in the treatment of major depression and general anxiety disorder. The aim of this study was to identify proteins regulated by this class of antidepressant using a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6002cc11f300ccdfba35a3e001c74f7
https://doi.org/10.1002/jnr.10869

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Immunohistochemical Localization of G Protein β1, β2, β3, β4, β5, and γ3 Subunits in the Adult Rat Brain

Autor: Xavier Z. Khawaja, Jin-Jun Liang, Mark I. Cockett

Publikováno v: Journal of Neurochemistry. 71:345-355

The regional distributions of the G protein beta subunits (Gbeta1-beta5) and of the Ggamma3 subunit were examined by immunohistochemical methods in the adult rat brain. In general, the Gbeta and Ggamma3 subunits were widely distributed throughout the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d151d83e960c2624ca103b9e1b1e2a6
https://doi.org/10.1046/j.1471-4159.1998.71010345.x

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RGS7 complex formation and colocalization with the G?5 subunit in the adult rat brain and influence on G?5?2-mediated PLC? signaling

Autor: Philip G. Jones, Jin-Jun Liang, Xavier Z. Khawaja, Hui Hong D. Chen

Publikováno v: Journal of Neuroscience Research. 60:58-64

This study describes the colocalized distribution and dimeric complex formation between RGS7, a GTPase-activating protein for several heterotrimeric Galpha protein families, and the Gbeta5 subunit in the adult rat brain. Confocal dual immunofluoresce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17e8b19a64c6932c221e9721ae32c270
https://doi.org/10.1002/(sici)1097-4547(20000401)60:1<58::aid-jnr6>3.0.co

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Probing for drug-induced multiplex signal transduction pathways using high resolution two-dimensional gel electrophoresis: application to β-adrenoceptor stimulation in the rat C6 glioma cell

Autor: Stephen M Storm, Xavier Z. Khawaja

Publikováno v: Molecular Brain Research. 71:50-60

Whole-cell [ 32 P ]-protein phosphorylation assays and two-dimensional gel electrophoresis (2-DGE) were applied to the analysis of the β-adrenoceptor (βAR)-linked signal transduction pathway. Rat C6 glioma cells were stimulated with isoproterenol a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873d9541307b4ed08840466dc52e0cf5
https://doi.org/10.1016/s0169-328x(99)00167-9

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