Faeces‐derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases

Autor: Lionel Fizanne, Alexandre Villard, Nadia Benabbou, Sylvain Recoquillon, Raffaella Soleti, Erwan Delage, Mireille Wertheimer, Xavier Vidal‐Gómez, Thibauld Oullier, Samuel Chaffron, M. Carmen Martínez, Michel Neunlist, Jérôme Boursier, Ramaroson Andriantsitohaina

Publikováno v: Journal of Extracellular Vesicles, Vol 12, Iss 2, Pp n/a-n/a (2023)

Abstract The role of extracellular vesicles (EVs) from faeces (fEVs) and small circulating EVs (cEVs) in liver diseases such as non‐alcoholic fatty diseases (NAFLD) and non‐alcoholic steatohepatitis (NASH) has not been demonstrated. fEVs and cEVs

Externí odkaz: https://doaj.org/article/80ae99f48313493eb63aa1f14389c5aa

Regulatory Network Analysis in Estradiol-Treated Human Endothelial Cells

Autor: Daniel Pérez-Cremades, Ana B. Paes, Xavier Vidal-Gómez, Ana Mompeón, Carlos Hermenegildo, Susana Novella

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 15, p 8193 (2021)

Background/Aims: Estrogen has been reported to have beneficial effects on vascular biology through direct actions on endothelium. Together with transcription factors, miRNAs are the major drivers of gene expression and signaling networks. The objecti

Externí odkaz: https://doaj.org/article/80e14f2be662485091f962745c2e7a26

LPS-enriched small extracellular vesicles from metabolic syndrome patients trigger endothelial dysfunction by activation of TLR4

Autor: Gilles Simard, Zainab Safiedeen, Arnaud Chevrollier, Sakina Ali, Ramaroson Andriantsitohaina, Luisa Vergori, M. Carmen Martinez, Soazig Le Lay, Xavier Vidal-Gómez, Frédéric Gagnadoux, Marine Malloci, Jérôme Boursier, Charlène Besnard, Raffaella Soleti, Séverine Dubois

Publikováno v: Metabolism
Metabolism, Elsevier, 2021, 118, pp.154727. ⟨10.1016/j.metabol.2021.154727⟩
Metabolism, 2021, 118, pp.154727. ⟨10.1016/j.metabol.2021.154727⟩

Background Metabolic syndrome (MetS) is characterized by a cluster of interconnected risk factors -hyperglycemia, dyslipidemia, hypertension and obesity- leading to an increased risk of cardiovascular events. Small extracellular vesicles (sEVs) can b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2664bef9bc6295907d692dda54fb0307
https://hal.univ-angers.fr/hal-03284090

Estradiol, acting through ERα, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1–7 production

Autor: Daniel Pérez-Cremades, Elena Monsalve, Carlos Hermenegildo, Carlos Bueno-Betí, Ana Mompeón, Macarena Lázaro-Franco, Xavier Vidal-Gómez, Susana Novella, Mariela M. Gironacci

Publikováno v: Molecular and Cellular Endocrinology. 422:1-8

Intracellular renin-angiotensin system (RAS) can operate independently of the circulating RAS. Estrogens provide protective effects by modulating the RAS. Our aim was to investigate the effect of estradiol (E2) on angiotensin converting enzymes (ACE)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7db152518fd7c771cc6b4037060baae
https://doi.org/10.1016/j.mce.2015.11.004

miRNA as New Regulatory Mechanism of Estrogen Vascular Action

Autor: Carlos Hermenegildo, Ana Mompeón, Xavier Vidal-Gómez, Daniel Pérez-Cremades, Susana Novella

Publikováno v: Pérez-Cremades, Daniel Mompeón, Ana Vidal-Gómez, Xavier Hermenegildo, Carlos Novella, Susana 2018 miRNA as New Regulatory Mechanism of Estrogen Vascular Action International Journal Of Molecular Sciences 19 473
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 2, p 473 (2018)
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
RODERIC: Repositorio Institucional de la Universitat de Valéncia

The beneficial effects of estrogen on the cardiovascular system have been reported extensively. In fact, the incidence of cardiovascular diseases in women is lower than in age-matched men during their fertile stage of life, a benefit that disappears

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f5de234da18ff0a44e09c08033fc2f
https://hdl.handle.net/10550/75705