Výsledky vyhledávání - "Xavier V, Gomes"

Genome sequencing in microfabricated high-density picolitre reactors

Autor: Marcel, Margulies, Michael, Egholm, William E, Altman, Said, Attiya, Joel S, Bader, Lisa A, Bemben, Jan, Berka, Michael S, Braverman, Yi-Ju, Chen, Zhoutao, Chen, Scott B, Dewell, Lei, Du, Joseph M, Fierro, Xavier V, Gomes, Brian C, Godwin, Wen, He, Scott, Helgesen, Chun Heen, Ho, Chun He, Ho, Gerard P, Irzyk, Szilveszter C, Jando, Maria L I, Alenquer, Thomas P, Jarvie, Kshama B, Jirage, Jong-Bum, Kim, James R, Knight, Janna R, Lanza, John H, Leamon, Steven M, Lefkowitz, Ming, Lei, Jing, Li, Kenton L, Lohman, Hong, Lu, Vinod B, Makhijani, Keith E, McDade, Michael P, McKenna, Eugene W, Myers, Elizabeth, Nickerson, John R, Nobile, Ramona, Plant, Bernard P, Puc, Michael T, Ronan, George T, Roth, Gary J, Sarkis, Jan Fredrik, Simons, John W, Simpson, Maithreyan, Srinivasan, Karrie R, Tartaro, Alexander, Tomasz, Kari A, Vogt, Greg A, Volkmer, Shally H, Wang, Yong, Wang, Michael P, Weiner, Pengguang, Yu, Richard F, Begley, Jonathan M, Rothberg

Publikováno v: Nature. 437:376-380

The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with raw throughput significantly greater tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be63f61c869490283189d10b7b7d43b2
https://doi.org/10.1038/nature03959

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Okazaki Fragment Maturation in Yeast

Autor: Dmitry A. Gordenin, Peter M. J. Burgers, Xavier V. Gomes, Rao Ayyagari

Publikováno v: Journal of Biological Chemistry. 278:1618-1625

In the presence of proliferating cell nuclear antigen, yeast DNA polymerase δ (Pol δ) replicated DNA at a rate of 40–60 nt/s. When downstream double-stranded DNA was encountered, Pol δ paused, but most replication complexes proceeded to carry ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0bc9d5ede83e63e6d88469160726d96
https://doi.org/10.1074/jbc.m209801200

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ATP Utilization by Yeast Replication Factor C

Autor: Xavier V. Gomes, Peter M. J. Burgers

Publikováno v: Journal of Biological Chemistry. 276:34768-34775

Eukaryotic replication factor C is the heteropentameric complex that loads the replication clamp proliferating cell nuclear antigen (PCNA) onto primed DNA. In this study we used a derivative, designated RFC, with a N-terminal truncation of the Rfc1 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed7125709ced0a2b8b3c6e9caf83e646
https://doi.org/10.1074/jbc.m011631200

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ATP Utilization by Yeast Replication Factor C

Autor: Sonja L.Gary Schmidt, Xavier V. Gomes, Peter M. J. Burgers

Publikováno v: Journal of Biological Chemistry. 276:34792-34800

Replication factor C is required to load proliferating cell nuclear antigen onto primer-template junctions, using the energy of ATP hydrolysis. Four of the five RFCgenes have consensus ATP-binding motifs. To determine the relative importance of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d584548939c732d6060b6a664ef6bee
https://doi.org/10.1074/jbc.m011671200

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Two modes of FEN1 binding to PCNA regulated by DNA

Autor: Xavier V. Gomes, Peter M. J. Burgers

Publikováno v: The EMBO Journal. 19:3811-3821

The FEN1 nuclease functions during Okazaki fragment maturation in the eukaryotic cell. Like many other proliferating cell nuclear antigen (PCNA)-binding proteins, FEN1 interacts with the interdomain connector loop (IDCL) of PCNA, and PCNA greatly sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0158f0ee41153165e8d03d4221f278
https://doi.org/10.1093/emboj/19.14.3811

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Overproduction in Escherichia coli and Characterization of Yeast Replication Factor C Lacking the Ligase Homology Domain

Autor: Peter M. J. Burgers, Sonja L. Gary, Xavier V. Gomes

Publikováno v: Journal of Biological Chemistry. 275:14541-14549

Eukaryotic replication factor C (RF-C) is a heteropentameric complex that is required to load the replication clamp proliferating cell nuclear antigen onto primed DNA. Saccharomyces cerevisiae RF-C is encoded by the genes RFC1-RFC5. The RFC1 gene was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da1a6a6abb83d5bc4ddfdcf494fe00b
https://doi.org/10.1074/jbc.275.19.14541

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Replication Protein A Interactions with DNA. 1. Functions of the DNA-Binding and Zinc-Finger Domains of the 70-kDa Subunit

Autor: Chang Geun Lee, André P. Walther, Marc S. Wold, Ye Lao, Xavier V. Gomes

Publikováno v: Biochemistry. 38:3963-3973

Human replication protein A (RPA) is a multiple subunit single-stranded DNA-binding protein that is required for multiple processes in cellular DNA metabolism. This complex, composed of subunits of 70, 32, and 14 kDa, binds to single-stranded DNA (ss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8550603e32ffd64b38b0d0c12b411419
https://doi.org/10.1021/bi982370u

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[Untitled]

Autor: Marc S. Wold, Andrew S. Lipton, Nancy G. Isern, Xavier V. Gomes, Doris M. Jacobs, Gary W. Daughdrill, David F. Lowry

Publikováno v: Journal of Biomolecular NMR. 14:321-331

Human Replication Protein A (hsRPA) is required for multiple cellular processes in DNA metabolism including DNA repair, replication and recombination. It binds single-stranded DNA with high affinity and interacts specifically with multiple proteins.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c513871b72755240f2fa03634beb7f4
https://doi.org/10.1023/a:1008373009786

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Functional Domains of the 70-Kilodalton Subunit of Human Replication Protein A

Autor: Marc S. Wold, Xavier V. Gomes

Publikováno v: Biochemistry. 35:10558-10568

Human replication protein A (RPA) is a single-stranded DNA-binding protein that is composed of subunits of 70, 32, and 14 kDa. This heterotrimeric complex is required for multiple processes in DNA metabolism including DNA replication, DNA repair, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb0b2903f049c508bd555888485e6c8
https://doi.org/10.1021/bi9607517

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