Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Xavier Trepat"'
Autor:
Sefora Conti, Valeria Venturini, Adrià Cañellas-Socias, Carme Cortina, Juan F. Abenza, Camille Stephan-Otto Attolini, Emily Middendorp Guerra, Catherine K. Xu, Jia Hui Li, Leone Rossetti, Giorgio Stassi, Pere Roca-Cusachs, Alba Diz-Muñoz, Verena Ruprecht, Jochen Guck, Eduard Batlle, Anna Labernadie, Xavier Trepat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical properties, and how thes
Externí odkaz:
https://doaj.org/article/f3eda4b90df041b09e2517b0f47ce22e
Autor:
Jorge Barbazan, Carlos Pérez-González, Manuel Gómez-González, Mathieu Dedenon, Sophie Richon, Ernest Latorre, Marco Serra, Pascale Mariani, Stéphanie Descroix, Pierre Sens, Xavier Trepat, Danijela Matic Vignjevic
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract During tumor progression, cancer-associated fibroblasts (CAFs) accumulate in tumors and produce an excessive extracellular matrix (ECM), forming a capsule that enwraps cancer cells. This capsule acts as a barrier that restricts tumor growth
Externí odkaz:
https://doaj.org/article/bf69cb6b0c6648a4856ecfc4e5980a6c
Autor:
Ariadna Marín-Llauradó, Sohan Kale, Adam Ouzeri, Tom Golde, Raimon Sunyer, Alejandro Torres-Sánchez, Ernest Latorre, Manuel Gómez-González, Pere Roca-Cusachs, Marino Arroyo, Xavier Trepat
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The function of organs such as lungs, kidneys and mammary glands relies on the three-dimensional geometry of their epithelium. To adopt shapes such as spheres, tubes and ellipsoids, epithelia generate mechanical stresses that are generally u
Externí odkaz:
https://doaj.org/article/c4079dd0644b4de5b3e69a85e0e594ea
Autor:
Xarxa Quiroga, Nikhil Walani, Andrea Disanza, Albert Chavero, Alexandra Mittens, Francesc Tebar, Xavier Trepat, Robert G Parton, María Isabel Geli, Giorgio Scita, Marino Arroyo, Anabel-Lise Le Roux, Pere Roca-Cusachs
Publikováno v:
eLife, Vol 12 (2023)
As cells migrate and experience forces from their surroundings, they constantly undergo mechanical deformations which reshape their plasma membrane (PM). To maintain homeostasis, cells need to detect and restore such changes, not only in terms of ove
Externí odkaz:
https://doaj.org/article/e420404ec4474c4ba1e511bee981ae9a
Autor:
Guillermo Martínez-Ara, Núria Taberner, Mami Takayama, Elissavet Sandaltzopoulou, Casandra E. Villava, Miquel Bosch-Padrós, Nozomu Takata, Xavier Trepat, Mototsugu Eiraku, Miki Ebisuya
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Apical constriction is a force-generating process required during embryonic development; there is a lack of tools to manipulate 3D shapes of mammalian tissues. Here the authors report the optogenetic method, OptoShroom3, to achieve fast spatiotempora
Externí odkaz:
https://doaj.org/article/6b30781780f940a2b12488a8bc02e9e6
Autor:
Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani, Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo, Pere Roca-Cusachs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Amphiphysin BAR proteins reshape membranes, but the dynamics of the process remained unexplored. Here, the authors show through experiment and modelling that reshaping depends on the initial template shape, occurs even at low initial curvature, and i
Externí odkaz:
https://doaj.org/article/3b9d4c84264247a5a7e94d78fc4c48cf
Autor:
Fidel-Nicolás Lolo, Dácil María Pavón, Araceli Grande-García, Alberto Elosegui-Artola, Valeria Inés Segatori, Sara Sánchez, Xavier Trepat, Pere Roca-Cusachs, Miguel A del Pozo
Publikováno v:
eLife, Vol 11 (2022)
Cells are subjected to multiple mechanical inputs throughout their lives. Their ability to detect these environmental cues is called mechanosensing, a process in which integrins play an important role. During cellular mechanosensing, plasma membrane
Externí odkaz:
https://doaj.org/article/016b66b718ba426992b2d7853f29df07
Autor:
Chiara Zambarda, Carlos Pérez González, Andreas Schoenit, Nisha Veits, Clara Schimmer, Raimund Jung, Dirk Ollech, Joel Christian, Pere Roca-Cusachs, Xavier Trepat, Elisabetta Ada Cavalcanti-Adam
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 4, Pp 151274- (2022)
Several factors present in the extracellular environment regulate epithelial cell adhesion and dynamics. Among them, growth factors such as EGF, upon binding to their receptors at the cell surface, get internalized and directly activate the acto-myos
Externí odkaz:
https://doaj.org/article/a7aecba09d4e4db0843a78412505db80
Autor:
Ion Andreu, Bryan Falcones, Sebastian Hurst, Nimesh Chahare, Xarxa Quiroga, Anabel-Lise Le Roux, Zanetta Kechagia, Amy E. M. Beedle, Alberto Elosegui-Artola, Xavier Trepat, Ramon Farré, Timo Betz, Isaac Almendros, Pere Roca-Cusachs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cells sense mechanical forces from their environment, but the precise mechanical variable sensed by cells is unclear. Here, the authors show that cells can sense the rate of force application, known as the loading rate, with effects on YAP nuclear lo
Externí odkaz:
https://doaj.org/article/58de45fe25454986bcf5d32016e837d2
Autor:
Ana López-Mengual, Miriam Segura-Feliu, Raimon Sunyer, Héctor Sanz-Fraile, Jorge Otero, Francina Mesquida-Veny, Vanessa Gil, Arnau Hervera, Isidre Ferrer, Jordi Soriano, Xavier Trepat, Ramon Farré, Daniel Navajas, José Antonio del Río
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Emerging evidence points to coordinated action of chemical and mechanical cues during brain development. At early stages of neocortical development, angiogenic factors and chemokines such as CXCL12, ephrins, and semaphorins assume crucial roles in or
Externí odkaz:
https://doaj.org/article/adabe2fef752439cafd64b2d6fd34937