Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Xavier Prasanna"'
Autor:
Liang Wang, Ziyun Yang, Fudo Satoshi, Xavier Prasanna, Ziyi Yan, Helena Vihinen, Yaxing Chen, Yue Zhao, Xiumei He, Qian Bu, Hongchun Li, Ying Zhao, Linhong Jiang, Feng Qin, Yanping Dai, Ni Zhang, Meng Qin, Weihong Kuang, Yinglan Zhao, Eija Jokitalo, Ilpo Vattulainen, Tommi Kajander, Hongxia Zhao, Xiaobo Cen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-30 (2024)
Abstract The Bin/Amphiphysin/Rvs (BAR) domain protein FAM92A1 is a multifunctional protein engaged in regulating mitochondrial ultrastructure and ciliogenesis, but its physiological role in the brain remains unclear. Here, we show that FAM92A1 is exp
Externí odkaz:
https://doaj.org/article/345ca2ed37524fef9b09f5e108e25a96
Autor:
Calvin Dumesnil, Lauri Vanharanta, Xavier Prasanna, Mohyeddine Omrane, Maxime Carpentier, Apoorva Bhapkar, Giray Enkavi, Veijo T. Salo, Ilpo Vattulainen, Elina Ikonen, Abdou Rachid Thiam
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Dumesnil et al. report that cholesterol esters (CE), which only melt above body temperature, form supercooled liquid crystalline lipid droplets (LD). Triacylglycerols (TG) solubilize CE to help CE LD nucleation. Through clustering TGs in the ER membr
Externí odkaz:
https://doaj.org/article/1cacaf49d32d4b7a9a98a9bcd3cf7d33
Autor:
Xavier Prasanna, Veijo T Salo, Shiqian Li, Katharina Ven, Helena Vihinen, Eija Jokitalo, Ilpo Vattulainen, Elina Ikonen
Publikováno v:
PLoS Biology, Vol 19, Iss 1, p e3000998 (2021)
Seipin is a disk-like oligomeric endoplasmic reticulum (ER) protein important for lipid droplet (LD) biogenesis and triacylglycerol (TAG) delivery to growing LDs. Here we show through biomolecular simulations bridged to experiments that seipin can tr
Externí odkaz:
https://doaj.org/article/c8f7f019484345a49fecb9938555c2ef
Publikováno v:
Nature Methods. 16:866-869
Auxin-inducible degron technology allows rapid and controlled protein depletion. However, basal degradation without auxin and inefficient auxin-inducible depletion have limited its utility. We have identified a potent auxin-inducible degron system co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ec9e47a423566ab03858e3673decad
https://doi.org/10.1038/s41592-019-0512-x
https://doi.org/10.1038/s41592-019-0512-x
Autor:
Helena Vihinen, Ilpo Vattulainen, Eija Jokitalo, Katharina Ven, Shiqian Li, Veijo T. Salo, Elina Ikonen, Xavier Prasanna
Seipin is a disk-like oligomeric ER protein important for lipid droplet (LD) biogenesis and triacylglycerol (TAG) delivery to growing LDs. Here we show through biomolecular simulations bridged to experiments that seipin can trap TAGs in the ER bilaye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05888717a805fca469d5d6cef4b3bb96
https://doi.org/10.1101/2020.10.26.355065
https://doi.org/10.1101/2020.10.26.355065
Publikováno v:
The Journal of Physical Chemistry B. 121:2111-2120
The insertion and association of membrane proteins is critical in several cellular processes. These processes were thought to be protein-driven, but increasing evidence points toward an important role of the lipid bilayer. The lipid-mediated contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c82ea377a686d0737e4ce1dffeba34
https://doi.org/10.1021/acs.jpcb.6b09863
https://doi.org/10.1021/acs.jpcb.6b09863
Publikováno v:
Chemistry and physics of lipids. 227
G protein-coupled receptors (GPCRs) are transmembrane receptors that mediate a large number of cellular responses. The organization of GPCRs into dimers and higher-order oligomers is known to allow a larger repertoire of downstream signaling events.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c55f27f6f569afa6597863e4cde27b9
https://pubmed.ncbi.nlm.nih.gov/31866438
https://pubmed.ncbi.nlm.nih.gov/31866438
Publikováno v:
Nature methods. 16(9)
Auxin-inducible degron technology allows rapid and controlled protein depletion. However, basal degradation without auxin and inefficient auxin-inducible depletion have limited its utility. We have identified a potent auxin-inducible degron system co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a50f9885bf762062d8ddf78268939605
https://pubmed.ncbi.nlm.nih.gov/31636461
https://pubmed.ncbi.nlm.nih.gov/31636461
Publikováno v:
Advances in experimental medicine and biology. 1112
The interaction of G protein-coupled receptors (GPCRs) with cholesterol is a hallmark of their function, organization, and structural dynamics. Several cholesterol interaction sites, such as the cholesterol recognition amino acid consensus (CRAC) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::164380d5bf7d76154289cdedba81a170
https://pubmed.ncbi.nlm.nih.gov/30637696
https://pubmed.ncbi.nlm.nih.gov/30637696
Autor:
Katharina Ven, Helena Vihinen, Shiqian Li, Xavier Prasanna, Veijo T. Salo, Elina Ikonen, Eija Jokitalo, Ilpo Vattulainen
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 1, p e3000998 (2021)
PLoS Biology, Vol 19, Iss 1, p e3000998 (2021)
Seipin is a disk-like oligomeric endoplasmic reticulum (ER) protein important for lipid droplet (LD) biogenesis and triacylglycerol (TAG) delivery to growing LDs. Here we show through biomolecular simulations bridged to experiments that seipin can tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d4547884f67f34b0a02e130690adb5
https://doi.org/10.1371/journal.pbio.3000998
https://doi.org/10.1371/journal.pbio.3000998