Výsledky vyhledávání - "Xavier Mouska"

Akademický článek

MOG-specific CAR Tregs: a novel approach to treat multiple sclerosis

Autor: Jihane Frikeche, Marion David, Xavier Mouska, Damien Treguer, Yue Cui, Sandrine Rouquier, Enora Lecorgne, Emma Proics, Papa Babacar Fall, Audrey Lafon, Gregory Lara, Alexandra Menardi, David Fenard, Tobias Abel, Julie Gertner-Dardenne, Maurus de la Rosa, Celine Dumont

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-16 (2024)

Abstract Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system (CNS) with the immune system attacking myelin sheaths leading to neuronal death. While several disease-modifying therapies are available to treat MS, these

Externí odkaz: https://doaj.org/article/b0d2facc0d0543fd93f28c1fda2eaf9c

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Akademický článek

Identification of an acute functional cross-talk between amyloid-β and glucocorticoid receptors at hippocampal excitatory synapses

Autor: Scherazad Kootar, Marie-Lise Frandemiche, Gihen Dhib, Xavier Mouska, Thomas Lorivel, Gwenola Poupon-Silvestre, Hazel Hunt, François Tronche, Ingrid Bethus, Jacques Barik, Hélène Marie

Publikováno v: Neurobiology of Disease, Vol 118, Iss , Pp 117-128 (2018)

Amyloid-β is a peptide released by synapses in physiological conditions and its pathological accumulation in brain structures necessary for memory processing represents a key toxic hallmark underlying Alzheimer's disease. The oligomeric form of Amyl

Externí odkaz: https://doaj.org/article/a050fd3aebf44dee838d51a1cf521f67

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Akademický článek

Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors

Autor: Sebastian P. Fernandez, Loïc Broussot, Fabio Marti, Thomas Contesse, Xavier Mouska, Mariano Soiza-Reilly, Hélène Marie, Philippe Faure, Jacques Barik

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Dopamine neurons in the ventral tegmental area (VTA) are implicated in depressive-like behaviors. Here, the authors show that cholinergic inputs to the VTA from the laterodorsal tegmentum regulate intrinsic plasticity of VTA DA neurons to mediate str

Externí odkaz: https://doaj.org/article/7a4f1423a5b94bea8614630b86067284

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Akademický článek

Fmr1-Deficiency Impacts Body Composition, Skeleton, and Bone Microstructure in a Mouse Model of Fragile X Syndrome

Autor: Antoine Leboucher, Patricia Bermudez-Martin, Xavier Mouska, Ez-Zoubir Amri, Didier F. Pisani, Laetitia Davidovic

Publikováno v: Frontiers in Endocrinology, Vol 10 (2019)

Fragile X syndrome (FXS) is a neurodevelopmental disorder associated with intellectual disability, hyperactivity, and autism. FXS is due to the silencing of the X-linked FMR1 gene. Murine models of FXS, knock-out (KO) for the murine homolog Fmr1, hav

Externí odkaz: https://doaj.org/article/df11223abb414054b5593b9a4548c9b3

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Akademický článek

The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding

Autor: Paula A. Pousinha, Xavier Mouska, Daniela Bianchi, Mariana Temido-Ferreira, Joana Rajão-Saraiva, Rui Gomes, Sebastian P. Fernandez, Ana Rita Salgueiro-Pereira, Carine Gandin, Elisabeth F. Raymond, Jacques Barik, Romain Goutagny, Ingrid Bethus, Luisa V. Lopes, Michele Migliore, Hélène Marie

Publikováno v: Cell Reports, Vol 29, Iss 2, Pp 317-331.e5 (2019)

Summary: There is a growing consensus that Alzheimer's disease (AD) involves failure of the homeostatic machinery, which underlies the firing stability of neural circuits. What are the culprits leading to neuron firing instability? The amyloid precur

Externí odkaz: https://doaj.org/article/90855fdcacba470a93f8234bea3604cb

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Akademický článek

Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

Autor: Paula A Pousinha, Xavier Mouska, Elisabeth F Raymond, Carole Gwizdek, Gihen Dhib, Gwenola Poupon, Laure-Emmanuelle Zaragosi, Camilla Giudici, Ingrid Bethus, Emilie Pacary, Michael Willem, Hélène Marie

Publikováno v: eLife, Vol 6 (2017)

The amyloid precursor protein (APP) harbors physiological roles at synapses and is central to Alzheimer’s disease (AD) pathogenesis. Evidence suggests that APP intracellular domain (AICD) could regulate synapse function, but the underlying molecula

Externí odkaz: https://doaj.org/article/ccaada73b4cf460eb4fd4f2215414df4

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Combination of blood and biphasic calcium phosphate microparticles for the reconstruction of large bone defects in dog: A pilot study

Autor: Ez-Zoubir Amri, Christophe Trojani, Damien Ambrosetti, Thierry Balaguer, Olivier Gauthier, Jean-Michel Bouler, Marine Traverson, Xavier Mouska, Florian Boukhechba, Bérengère Dadone, Nathalie Rochet, Borhane H. Fellah, Jean-François Michiels

Publikováno v: Journal of Biomedical Materials Research Part A. 106:1842-1850

We previously reported that biphasic calcium phosphate (BCP) microparticles embedded in a blood clot induces ectopic bone formation in mice and repairs a critical femoral defect in rat. The present pilot study aimed to evaluate in dog and in two mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca88647df43ecaf3ac342315ecc0cad5
https://doi.org/10.1002/jbm.a.36384

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Fmr1-Deficiency Impacts Body Composition, Skeleton, and Bone Microstructure in a Mouse Model of Fragile X Syndrome

Autor: Xavier Mouska, Ez-Zoubir Amri, Patricia Bermudez-Martin, Laetitia Davidovic, Didier F. Pisani, Antoine Leboucher

Publikováno v: Frontiers in Endocrinology
Frontiers in Endocrinology, Frontiers, 2019, 10, ⟨10.3389/fendo.2019.00678⟩
Frontiers in Endocrinology, Frontiers, 2019, 10, pp.678. ⟨10.3389/fendo.2019.00678⟩
Frontiers in Endocrinology, 2019, 10, pp.678. ⟨10.3389/fendo.2019.00678⟩
Frontiers in Endocrinology, Vol 10 (2019)

International audience; Fragile X syndrome (FXS) is a neurodevelopmental disorder associated with intellectual disability, hyperactivity, and autism. FXS is due to the silencing of the X-linked FMR1 gene. Murine models of FXS, knock-out (KO) for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b342224864fff004891ba3f599c1c151
https://hal.archives-ouvertes.fr/hal-02323472

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Identification of an acute functional cross-talk between amyloid-β and glucocorticoid receptors at hippocampal excitatory synapses

Autor: Hazel Hunt, François Tronche, Hélène Marie, Ingrid Bethus, Xavier Mouska, Gihen Dhib, Scherazad Kootar, Jacques Barik, Marie-Lise Frandemiche, Thomas Lorivel, Gwenola Poupon-Silvestre

Publikováno v: Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2018, 118, pp.117-128. ⟨10.1016/j.nbd.2018.07.001⟩
Neurobiology of Disease, Vol 118, Iss, Pp 117-128 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b843a0c4a092a40f5108a1299ec44dfc
https://pubmed.ncbi.nlm.nih.gov/30003950

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