Extending the molecular clutch beyond actin-based cell motility

Autor: Svitlana Havrylenko, Xavier Mezanges, Ellen Batchelder, Julie Plastino

Publikováno v: New Journal of Physics, Vol 16, Iss 10, p 105012 (2014)

Many cell movements occur via polymerization of the actin cytoskeleton beneath the plasma membrane at the front of the cell, forming a protrusion called a lamellipodium, while myosin contraction squeezes forward the back of the cell. In what is known

Externí odkaz: https://doaj.org/article/a74640af197649b4b0913dae06f5271a

Membrane tension regulates motility by controlling lamellipodium organization

Autor: Erik M. Jorgensen, Ellen L. Batchelder, Clément Campillo, Gunther Hollopeter, Pierre Nassoy, Julie Plastino, Pierre Sens, Xavier Mezanges

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (28), pp.11429-11434. ⟨10.1073/pnas.1010481108⟩
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (28), pp.11429-11434. ⟨10.1073/pnas.1010481108⟩

Many cell movements proceed via a crawling mechanism, where polymerization of the cytoskeletal protein actin pushes out the leading edge membrane. In this model, membrane tension has been seen as an impediment to filament growth and cell motility. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b81cf7fb28fabe82775a72900ed1c0a
https://hal.archives-ouvertes.fr/hal-02896087