Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Xavier Llor"'
Autor:
Adam Grant, Rosa M. Xicola, Vivian Nguyen, James Lim, Curtis Thorne, Bodour Salhia, Xavier Llor, Nathan Ellis, Megha Padi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The tumor suppressor gene adenomatous polyposis coli (APC) is the initiating mutation in approximately 80% of all colorectal cancers (CRC), underscoring the importance of aberrant regulation of intracellular WNT signaling in CRC development.
Externí odkaz:
https://doaj.org/article/bf640652481c4b5fb7c61c97c4880292
Autor:
Julyann Perez-Mayoral, Maria Gonzalez-Pons, Hilmaris Centeno-Girona, Ingrid M. Montes-Rodríguez, Marievelisse Soto-Salgado, Belisa Suárez, Natalia Rodríguez, Giancarlo Colón, Javier Sevilla, Daphne Jorge, Xavier Llor, Rosa M. Xicola, Doris H. Toro, Luis Tous-López, Marla Torres-Torres, José S. Reyes, Nicolas López-Acevedo, Ajay Goel, Segundo Rodríguez-Quilichini, Marcia Cruz-Correa
Publikováno v:
Genes, Vol 14, Iss 4, p 894 (2023)
Background: The incidence of sporadic colorectal cancer (CRC) among individuals KRAS and BRAF mutation status were analyzed. Sociodemographic and clinicopathological characteristics were evaluated using Chi-squared and Fisher’s exact tests. Results
Externí odkaz:
https://doaj.org/article/0c63a99f21a7475f9751fc025ae86eec
Autor:
Jae Hun Shin, Jaekwang Jeong, Jungmin Choi, Jaechul Lim, Ravi K. Dinesh, Jonathan Braverman, Jun Young Hong, Stephen E. Maher, Maria C. Amezcua Vesely, WonJu Kim, Ja-Hyun Koo, Wenwen Tang, Dianqing Wu, Holly N. Blackburn, Rosa M. Xicola, Xavier Llor, Omer Yilmaz, Je-Min Choi, Alfred L.M. Bothwell
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102411- (2021)
Summary: Enhanced stemness in colorectal cancer has been reported and it contributes to aggressive progression, but the underlying mechanisms remain unclear. Here we report a Wnt ligand, Dickkopf-2 (DKK2) is essential for developing colorectal cancer
Externí odkaz:
https://doaj.org/article/67458ed79ffd44e9bbd751bcc6f69111
Autor:
Aurelia Bustos, Artemio Payá, Andrés Torrubia, Rodrigo Jover, Xavier Llor, Xavier Bessa, Antoni Castells, Ángel Carracedo, Cristina Alenda
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1786 (2021)
The prediction of microsatellite instability (MSI) using deep learning (DL) techniques could have significant benefits, including reducing cost and increasing MSI testing of colorectal cancer (CRC) patients. Nonetheless, batch effects or systematic b
Externí odkaz:
https://doaj.org/article/2ba57efdc6dc4dd1b306e120b7f94fca
Autor:
Bradley J Nartowt, Gregory R Hart, David A Roffman, Xavier Llor, Issa Ali, Wazir Muhammad, Ying Liang, Jun Deng
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221421 (2019)
Colorectal cancer (CRC) is third in prevalence and mortality among all cancers in the US. Currently, the United States Preventative Services Task Force (USPSTF) recommends anyone ages 50-75 and/or with a family history to be screened for CRC. To impr
Externí odkaz:
https://doaj.org/article/7a39e3aeada7422db2bb9176d41e6485
Autor:
Oscar Murcia, Míriam Juárez, María Rodríguez-Soler, Eva Hernández-Illán, Mar Giner-Calabuig, Miren Alustiza, Cecilia Egoavil, Adela Castillejo, Cristina Alenda, Víctor Barberá, Carolina Mangas-Sanjuan, Ana Yuste, Luís Bujanda, Joan Clofent, Montserrat Andreu, Antoni Castells, Xavier Llor, Pedro Zapater, Rodrigo Jover
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203051 (2018)
OBJECTIVE:The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate each subtype's response to
Externí odkaz:
https://doaj.org/article/16decb5c201c4161a4fffd312ee4174c
Autor:
Yasushi Hamaya, Carla Guarinos, Stephanie S Tseng-Rogenski, Moriya Iwaizumi, Ritabrata Das, Rodrigo Jover, Antoni Castells, Xavier Llor, Montserrat Andreu, John M Carethers
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127591 (2015)
Elevated Microsatellite Alterations at Selected Tetranucleotide repeats (EMAST) is a genetic signature found in up to 60% of colorectal cancers (CRCs) that is caused by somatic dysfunction of the DNA mismatch repair (MMR) protein hMSH3. We have previ
Externí odkaz:
https://doaj.org/article/1767e9d27bc84e4d89a3772e4deed8bb
Autor:
Victoria Gonzalo, Juan Jose Lozano, Virginia Alonso-Espinaco, Leticia Moreira, Jenifer Muñoz, Maria Pellisé, Sergi Castellví-Bel, Xavier Bessa, Montserrat Andreu, Rosa M Xicola, Xavier Llor, Clara Ruiz-Ponte, Angel Carracedo, Rodrigo Jover, Antoni Castells, Francesc Balaguer, Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91033 (2014)
Epigenetics are thought to play a major role in the carcinogenesis of multiple sporadic colorectal cancers (CRC). Previous studies have suggested concordant DNA hypermethylation between tumor pairs. However, only a few methylation markers have been a
Externí odkaz:
https://doaj.org/article/f0a32a8c0b34487d9f0f0fd5034ba26d
Autor:
Lucia Perez-Carbonell, Francesc Balaguer, Yuji Toiyama, Cecilia Egoavil, Estefania Rojas, Carla Guarinos, Montserrat Andreu, Xavier Llor, Antoni Castells, Rodrigo Jover, C Richard Boland, Ajay Goel
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104285 (2014)
Aberrant hypermethylation of cancer-related genes has emerged as a promising strategy for the development of diagnostic, prognostic and predictive biomarkers in human cancer, including colorectal cancer (CRC). The aim of this study was to perform a s
Externí odkaz:
https://doaj.org/article/05c8a15f9cbd4cf3913f1b00a5dd905d
Autor:
Anna Abulí, Luis Bujanda, Jenifer Muñoz, Stephan Buch, Clemens Schafmayer, Maria Valeria Maiorana, Silvia Veneroni, Tom van Wezel, Tao Liu, Helga Westers, Clara Esteban-Jurado, Teresa Ocaña, Josep M Piqué, Montserrat Andreu, Rodrigo Jover, Angel Carracedo, Rosa M Xicola, Xavier Llor, Antoni Castells, EPICOLON Consortium, Malcolm Dunlop, Robert Hofstra, Annika Lindblom, Juul Wijnen, Paolo Peterlongo, Jochen Hampe, Clara Ruiz-Ponte, Sergi Castellví-Bel
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95022 (2014)
Colorectal cancer is one of the most frequent neoplasms and an important cause of mortality in the developed world. Mendelian syndromes account for about 5% of the total burden of CRC, being Lynch syndrome and familial adenomatous polyposis the most
Externí odkaz:
https://doaj.org/article/346b83e22aca4a92b69ec2e743525b29