Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Xavier Langlois"'
Autor:
Kathrin Wenger, Arthur Viode, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony Bannon, Rui Chang, Theresa R. Connors, Derek Oakley, Bernhard Renard, Juri Rappsilber, Bradley Hyman, Hanno Steen, Judith A. Steen
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract Background Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer’s Disease (AD) and while several drugs showed therapeutic effects in these mice, they were ineffective in hum
Externí odkaz:
https://doaj.org/article/0d7d9b70fb6e432d8c9dc6d0e97c6577
Autor:
Justine D. Manos, Christina N. Preiss, Nandini Venkat, Joseph Tamm, Peter Reinhardt, Taekyung Kwon, Jessica Wu, Allison D. Winter, Thomas R. Jahn, Kiran Yanamandra, Katherine Titterton, Eric Karran, Xavier Langlois
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103658- (2022)
Summary: Tau pathobiology has emerged as a key component underlying Alzheimer's disease (AD) progression; however, human neuronal in vitro models have struggled to recapitulate tau phenomena observed in vivo. Here, we aimed to define the minimal requ
Externí odkaz:
https://doaj.org/article/404fbb380b7c40598ab18adb2b081dcc
Autor:
Maarten Ooms, Sofie Celen, Ronald De Hoogt, Ilse Lenaerts, Johnny Liebregts, Greet Vanhoof, Xavier Langlois, Andrey Postnov, Michel Koole, Alfons Verbruggen, Koen Van Laere, Guy Bormans
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 1, Iss 1, Pp 1-17 (2016)
Abstract Background Phosphodiesterase 10A (PDE10A) is an important regulator of nigrostriatal dopamine (DA) neurotransmission. However, little is known on the effect of alterations in DA neurotransmission on PDE10A availability. Here, we used [18F]JN
Externí odkaz:
https://doaj.org/article/d4dd4237d5784bcaae606d3049b031e4
Autor:
Taekyung Kwon, Gen Lin, Sarah E. Chancellor, Astrid Wachter, Aicha Abdourahman, Rachel E Bennett, Fan Liao, Timothy Pastika, Joseph A. Tamm, Nandini Venkat, Kiran Yanamandra, Yelena Grinberg, Markus P. Kummer, Sudeshna Das, Tammy L. Dellovade, Eric H Karran, Robert V. Talanian, Knut Biber, Janina S Ried, Alberto Serrano‐Pozo, Xavier Langlois, Bradley T. Hyman
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Kathrin Wenger, Arthur Viode, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony Bannon, Theresa R. Connors, Derek Oakley, Bernhard Renard, Juri Rappsilber, Bradley Hyman, Hanno Steen, Judith Steen
Background: Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer’s Disease (AD) and while several drugs showed therapeutic effects in these mice, they were ineffective in humans. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d04f2e6a95d01dc81b248d4187f4f39
https://doi.org/10.21203/rs.3.rs-2056948/v1
https://doi.org/10.21203/rs.3.rs-2056948/v1
Autor:
Steven Deleye MSc, Ann-Marie Waldron MSc, Jill C. Richardson PhD, Mark Schmidt PhD, Xavier Langlois PhD, Sigrid Stroobants MD, PhD, Steven Staelens PhD
Publikováno v:
Molecular Imaging, Vol 15 (2016)
Introduction: In this study, the influence of physiological determinants on 18F-fluoro- d -glucose ( 18 F-FDG) brain uptake was evaluated in a mouse model of Alzheimer disease. Materials and Methods: TASTPM (Tg) and age-matched C57BL/6 J (WT) mice we
Externí odkaz:
https://doaj.org/article/a367047fc0644842a2d1c1a2ee15907f
Autor:
Steven Biesmans, Theo F. Meert, Jan A. Bouwknecht, Paul D. Acton, Nima Davoodi, Patrick De Haes, Jacobine Kuijlaars, Xavier Langlois, Liam J. R. Matthews, Luc Ver Donck, Niels Hellings, Rony Nuydens
Publikováno v:
Mediators of Inflammation, Vol 2013 (2013)
Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In t
Externí odkaz:
https://doaj.org/article/311938837c58467bba910192a119c888
Autor:
Astrid Bottelbergs, Xavier Langlois, Ann Marie Waldron, Steven Staelens, Bianca Van Broeck, Jeroen Verhaeghe, Leonie Wyffels, Steven Deleye, Sigrid Stroobants, Mark E. Schmidt
Publikováno v:
The Journal of nuclear medicine
In this study, we investigated the effects of chronic administration of an inhibitor of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) on Alzheimer-related pathology by multitracer PET imaging in transgenic APPPS1-21 (TG) mice. Met
Autor:
José Ignacio Andrés, Michel Koole, Diederik Moechars, Katleen Fierens, Xavier Langlois, Frederik J. R. Rombouts, Koen Van Laere, Guy Bormans, Lieven Declercq, Jonas Mariën, Rik Vandenberghe, Thomas Tousseyn, Gregor James Macdonald, Wim Vanduffel, Mark E. Schmidt, Alfons Verbruggen
Publikováno v:
Journal of Nuclear Medicine. 58:975-981
In this study, we have synthesized and evaluated 18F-JNJ64349311, a tracer with high affinity for aggregated tau (inhibition constant value, 8 nM) and high (≥500×) in vitro selectivity for tau over β-amyloid, in comparison with the benchmark comp
Autor:
Mark E. Schmidt, Rhys Salter, Cindy Wintmolders, Nigel Austin, Vladimir Chupakhin, Gregor James Macdonald, Astrid Bottelbergs, Paula te Riele, Lu Chen, Katleen Fierens, Diederik Moechars, Andrés A. Trabanco, José-Ignacio Andrés, José Manuel Alonso, Jonas Mariën, Erna Cleiren, Martinez Lamenca Carolina, Frederik J. R. Rombouts, Manuela Ariza, Leenaerts Joseph Elisabeth, Xavier Langlois, Wei Zhang, Alberto Fontana
Publikováno v:
Journal of Medicinal Chemistry. 60:1272-1291
A mini-HTS on 4000 compounds selected using 2D fragment-based similarity and 3D pharmacophoric and shape similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD a