Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Xavier Hermant"'
Autor:
Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis, Nicolas Barois, Fabien Delahaye, Bart Dermaut, Jean-Charles Lambert, Marcos R. Costa, Pierre Dourlen
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-23 (2022)
Abstract The Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer’s disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms. Here we observed in Drosophila that human BIN1 isoform1
Externí odkaz:
https://doaj.org/article/5a00e9ef0aa64aa8b839b112c52f6f26
Autor:
Erwan Lambert, Bart Dermaut, Nicolas Barois, Julien Chapuis, Farida Adelfettah, Pierre Dourlen, Fabien Delahaye, Patrik Verstreken, Philippe Amouyel, Amélie Bonnefond, Xavier Hermant, Arnaud Carrier, Marcos Romualdo Costa, Cloé Dupont, Alexandre Pelletier, Orthis Saha, Lindsay Davoine, Jean-Charles Lambert, Ana Raquel Melo de Farias, Bruna Soares Landeira, Frank Lafont
SUMMARYThe Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer’s disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms. Here we observed in Drosophila that human BIN1 isoform1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42f89e61f27f25556cd1daf3511ae6ef
https://doi.org/10.1101/2021.04.02.438184
https://doi.org/10.1101/2021.04.02.438184
Autor:
Xavier Hermant, Amandine Flaig, Dominique Cottel, Gilbert Briand, Brigitte Laillet, Chantal Simon, Aline Meirhaeghe, Marie-Adélaïde Bout, Julie Dumont, Dominique Arveiler, Aline Wagner, Jean Dallongeville, Charlotte Delay, Jean-Bernard Ruidavets, Jimena Luque-Bedregal, Jean Ferrières, Philippe Amouyel
Publikováno v:
Journal of clinical lipidology
Journal of clinical lipidology, Elsevier, 2018, 12 (5), pp.1280--1289. ⟨10.1016/j.jacl.2018.07.012⟩
Journal of clinical lipidology, 2018, 12 (5), pp.1280--1289. ⟨10.1016/j.jacl.2018.07.012⟩
Journal of clinical lipidology, Elsevier, 2018, 12 (5), pp.1280--1289. ⟨10.1016/j.jacl.2018.07.012⟩
Journal of clinical lipidology, 2018, 12 (5), pp.1280--1289. ⟨10.1016/j.jacl.2018.07.012⟩
International audience; BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Delta 5- and Delta 6-desaturases (encoded by the FADS] and FADS2 genes, respectively). Genome-wide association s
Autor:
Lindsay Davoine, Anne-Marie Ayral, Farida Abdelfettah, Xavier Hermant, Jean-Charles Lambert, Patrik Verstreken, Dirk Vandekerkhove, Erwan Lambert, Bart Dermaut, Philippe Amouyel, Nicolas Barois, Frank Lafont, Pierre Dourlen, Cloé Dupont, Julien Chapuis
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Sounnia Mediene-Benchekor, Aline Meirhaeghe, I. Hamani-Medjaoui, Hadjira Ouhaibi-Djellouli, Philippe Amouyel, Houssam Boulenouar, Djabaria Naïma Meroufel, Leila Houti, Sarah Aïcha Lardjam-Hetraf, Xavier Hermant, Benjamin Grenier-Boley, Louisa Goumidi, Nadhira Saidi-Mehtar
Publikováno v:
Gene. 567:159-163
article i nfo Background: In European populations, the NPPB rs198389 single nucleotide polymorphism (SNP) is associated with a reduced risk of type 2 diabetes mellitus (T2DM). We investigated the putative associations between NPPB rs198389, the T2DM
Autor:
Djabaria Naïma, Meroufel, Sounnia, Mediene-Benchekor, Sarah Aïcha, Lardjam-Hetraf, Hadjira, Ouhaïbi-Djellouli, Houssam, Boulenouar, Imane, Hamani-Medjaoui, Xavier, Hermant, Nadhira, Saïdi-Mehtar, Philippe, Amouyel, Leïla, Houti, Aline, Meirhaeghe, Louisa, Goumidi
Publikováno v:
International journal of clinical and experimental pathology. 8(6)
Genome-wide association studies have identified many lipid-associated loci primarily in European and Asian populations. In view of the differences between ethnic groups in terms of the frequency and impact of these variants, our objective was to eval
Autor:
Xavier Hermant, Philippe Amouyel, Sounnia Mediene-Benchekor, Louisa Goumidi, Aline Meirhaeghe, Leila Houti, Sarah Aïcha Lardjam-Hetraf, Houssam Boulenouar, Nadhira Saidi-Mehtar, Djabaria Naïma Meroufel, Hadjira Ouhaibi-Djellouli, I. Hamani-Medjaoui, Manel Nassima Badsi
Publikováno v:
BMC Genetics
Background Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and
Autor:
Philippe Amouyel, Nicolas Lamblin, Claude Foucher-Hossein, Pascal de Groote, Xavier Hermant, Jean Dallongeville, Eugène P. Mc Fadden, Nicole Helbecque, Christophe Bauters
Publikováno v:
Pharmacogenetics and Genomics. 15:137-142
Previous studies have clearly demonstrated the beneficial effect of beta-blockers in patients with stable congestive heart failure (CHF). beta-blockers improve left ventricular ejection fraction (LVEF) and reduce cardiac mortality. However, there is
Autor:
Nicole Helbecque, Christophe Bauters, Philippe Amouyel, Xavier Hermant, Pascal de Groote, Nicolas Lamblin, Jean Dallongeville
Publikováno v:
European Journal of Heart Failure. 6:17-21
Beta-adrenergic receptor blockade is an established treatment of chronic heart failure (HF). Previous studies have suggested a potential pharmacogenetic interaction between beta-blocker therapy and the angiotensin-converting enzyme (ACE) I/D polymorp
Autor:
Marie-Christine Chartier-Harlin, Florence Pasquier, Corinne Lendon, Xavier Hermant, U. Thaker, Dominique Cottel, Merrot S, Antonia L. Pritchard, Bernard Frigard, S. T. DeKosky, PM Conneally, Jean-Charles Lambert, A Houzet, A Hayes, Takeshi Iwatsubo, David G. Mann, Kamboh Mi, E. K. Luedecking-Zimmer, Philippe Amouyel, P Desai
Publikováno v:
Scopus-Elsevier
Although possession of the epsilon 4 allele of the apolipoprotein E gene appears to be an important biological marker for Alzheimer's disease (AD) susceptibility, strong evidence indicates that at least one additional risk gene exists on chromosome 1