Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Xavier Guillory"'
1
Akademický článek
Different binding modalities of quercetin to inositol-requiring enzyme 1 of S. cerevisiae and human lead to opposite regulation
Autor: S. Jalil Mahdizadeh, Johan Grandén, Diana Pelizzari-Raymundo, Xavier Guillory, Antonio Carlesso, Eric Chevet, Leif A. Eriksson
Publikováno v: Communications Chemistry, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The flavonoid Quercetin (Qe) was identified as an activator of Inositol-requiring enzyme 1 (IRE1) in S. cerevisiae (scIre1p), but its impact on human IRE1 (hIRE1) remains controversial due to the absence of a conserved Qe binding site. We ha
Externí odkaz: https://doaj.org/article/987ce2cf50b941f4876954d45013c533
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2
Akademický článek
A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment
Autor: Diana Pelizzari-Raymundo, Dimitrios Doultsinos, Raphael Pineau, Chloé Sauzay, Thodoris Koutsandreas, Timothy Langlais, Antonio Carlesso, Elena Gkotsi, Luc Negroni, Tony Avril, Aristotelis Chatziioannou, Eric Chevet, Leif A. Eriksson, Xavier Guillory
Publikováno v: iScience, Vol 26, Iss 5, Pp 106687- (2023)
Summary: Inositol-requiring enzyme 1 (IRE1) is a major mediator of the unfolded protein response (UPR), which is activated upon endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse microenvironmental cues, a stress overc
Externí odkaz: https://doaj.org/article/ec4db961d77f43c39ac1a07754c5bca7
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3
Akademický článek
Coalescent simulations indicate that the São Francisco River is a biogeographic barrier for six vertebrates in a seasonally dry South American forest
Autor: Felipe Eduardo Alves Coelho, Wilson Xavier Guillory, Marcelo Gehara
Publikováno v: Frontiers in Ecology and Evolution, Vol 10 (2022)
The riverine barrier hypothesis has been extensively explored in Neotropical rainforests, while its importance in drier regions such as the Caatinga, a seasonally dry tropical forest in northeastern Brazil, has only recently received more attention.
Externí odkaz: https://doaj.org/article/a66bdfe4589345d58e8d06623f2d9812
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4
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient
Autor: Delphine Leclerc, Louise Goujon, Sylvie Jaillard, Bénédicte Nouyou, Laurence Cluzeau, Léna Damaj, Christèle Dubourg, Amandine Etcheverry, Thierry Levade, Roseline Froissart, Stéphane Dréano, Xavier Guillory, Leif A Eriksson, Erika Launay, Frédéric Mouriaux, Marc-Antoine Belaud-Rotureau, Sylvie Odent, David Gilot
Publikováno v: The Crispr Journal
The Crispr Journal, 2023, 6 (1), pp.17-31. ⟨10.1089/crispr.2022.0045⟩
CRISPR J
International audience; Ganglioside-monosialic acid (GM1) gangliosidosis, a rare autosomal recessive disorder, is frequently caused by deleterious single nucleotide variants (SNVs) in GLB1 gene. These variants result in reduced β-galactosidase (β-g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4ea2bda2e416e0b000fd920fdf430b
https://hal.science/hal-03968195
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5
A novel blood brain barrier-permeable IRE1 kinase inhibitor for adjuvant glioblastoma treatment in mice
Autor: Diana Pelizzari-Raymundo, Dimitrios Doultsinos, Raphael Pineau, Chloé Sauzay, Thodoris Koutsandreas, Antonio Carlesso, Elena Gkotsi, Luc Negroni, Tony Avril, Aristotelis Chatziioannou, Eric Chevet, Leif A. Eriksson, Xavier Guillory
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease. It is a major mediator of the Unfolded Protein Response (UPR), which is activated during endoplasmic reticulum (ER) stress. Tumor cells experience ER s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0221f208dbb9d3ae4026991f868df499
https://doi.org/10.26434/chemrxiv-2022-2ld35-v2
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6
Pharmacological Targeting of IRE1 in Cancer
Autor: Dimitrios Doultsinos, Eric Chevet, Antonio Carlesso, Diana Pelizzari Raymundo, Xavier Guillory, Leif A. Eriksson
Publikováno v: Trends in Cancer
Trends in Cancer, 2020, 6 (12), pp.1018-1030. ⟨10.1016/j.trecan.2020.07.006⟩
Trends in Cancer, Cell Press, 2020, 6 (12), pp.1018-1030. ⟨10.1016/j.trecan.2020.07.006⟩
International audience; IRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of the unfolded protein response (UPR). IRE1α plays instrumental protumoral roles in several cancers, and high IRE1α activity has been associated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7a6accfb8d139d1854962004ffd2a3
https://doi.org/10.1016/j.trecan.2020.07.006
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10
Structure-Based Drug Discovery of IRE1 Modulators
Autor: Diana, Pelizzari Raymundo, Leif A, Eriksson, Eric, Chevet, Xavier, Guillory
Publikováno v: Methods in Molecular Biology
Methods in Molecular Biology, 2022, 2378, pp.293-315. ⟨10.1007/978-1-0716-1732-8_19⟩
International audience; IRE1α (inositol-requiring enzyme 1 alpha, referred to IRE1 hereafter) is an Endoplasmic Reticulum (ER) resident transmembrane enzyme with cytosolic kinase/RNAse activities. Upon ER stress IRE1 is activated through trans-autop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1fea2239a521d1f88ae0e494850ae6c6
https://hal.science/hal-03555111
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