Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Xavier Gómez‐Santacana"'
Autor:
Silvia Panarello, Aleix González-Díez, Alice E. Berizzi, Fanny Malhaire, Roser Borràs-Tudurí, Xavier Rovira, Carme Serra, Laurent Prézeau, Jean-Philippe Pin, Cyril Goudet, Amadeu Llebaria, Xavier Gómez-Santacana
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110123- (2024)
Summary: Metabotropic glutamate receptors (mGlu) regulate multiple functions in the nervous systems and are involved in several neurological disorders. However, selectively targeting individual mGlu subtypes with spatiotemporal precision is still an
Externí odkaz:
https://doaj.org/article/b18db773dee3473cb3b7f29e86502ea3
Autor:
Pawel Matulewicz, Arnau Ramos-Prats, Xavier Gómez-Santacana, Amadeu Llebaria, Francesco Ferraguti
Publikováno v:
Cells, Vol 11, Iss 22, p 3555 (2022)
Metabotropic glutamate 5 receptors (mGlu5) are thought to play an important role in mediating emotional information processing. In particular, negative allosteric modulators (NAMs) of mGlu5 have received a lot of attention as potential novel treatmen
Externí odkaz:
https://doaj.org/article/3976892b863d48aeac4086ab6fb7d06a
Autor:
Xavier Gómez-Santacana, Sabrina M. de Munnik, Tamara A. M. Mocking, Niels J. Hauwert, Shanliang Sun, Prashanna Vijayachandran, Iwan J. P. de Esch, Henry F. Vischer, Maikel Wijtmans, Rob Leurs
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2509-2523 (2019)
We report a detailed structure–activity relationship for the scaffold of VUF16216, a compound we have previously communicated as a small-molecule efficacy photoswitch for the peptidergic chemokine GPCR CXCR3. A series of photoswitchable azobenzene
Externí odkaz:
https://doaj.org/article/191d27a959cf464cbd751133e1acc2e9
Autor:
Xavier Gómez-Santacana, Silvia Pittolo, Xavier Rovira, Marc Lopez, Charleine Zussy, James A. R. Dalton, Adèle Faucherre, Chris Jopling, Jean-Philippe Pin, Francisco Ciruela, Cyril Goudet, Jesús Giraldo, Pau Gorostiza, Amadeu Llebaria
Publikováno v:
ACS Central Science, Vol 3, Iss 1, Pp 81-91 (2016)
Externí odkaz:
https://doaj.org/article/577f206eea3043b0b6d96b17807041f1
Publikováno v:
Molecular Photoswitches. :921-944
G-protein-coupled receptors (GPCRs) are a super-family of membrane proteins and major targets for drug development. However, many GPCRs drug candidates suffer from a lack of selectivity. Photopharmacology gives the possibility of modulating GPCR acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05911a14ffe310372aeb8ed5feec2b3d
https://doi.org/10.1002/9783527827626.ch37
https://doi.org/10.1002/9783527827626.ch37
Autor:
Xavier Gómez-Santacana, Marin Boutonnet, Carles Martínez-Juvés, Juan Lorenzo Catena, Enora Moutin, Thomas Roux, Eric Trinquet, Laurent Lamarque, Julie Perroy, Laurent Prézeau, Jurriaan M. Zwier, Jean-Philippe Pin, Amadeu Llebaria
New technologies based on luminescence have been essential to monitor the organization, signaling, trafficking or ligand binding of G Protein-Coupled Receptors (GPCRs), but they rely on the overexpression of genetically modified receptors. As more an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7846be38ae04e927e80c08d155bca71f
http://hdl.handle.net/10261/304936
http://hdl.handle.net/10261/304936
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Metabotropic glutamate receptors (mGlu) are a family of class C G protein-coupled receptors (GPCRs) with important biological functions and widespread expression. The mechanisms of mGlu activation and the development of allosteric modulators for thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e648d6091c064cc0b6937cabd680afc8
https://api.elsevier.com/content/abstract/scopus_id/85134815151
https://api.elsevier.com/content/abstract/scopus_id/85134815151
Autor:
François Hoh, Julie Kniazeff, Juan Lorenzo Catena, Cyril Goudet, Jean-Philippe Pin, Xavier Gómez-Santacana, Anaëlle Dumazer, Jean-Louis Banères, Ludovic Berto, Fanny Malhaire, Amadeu Llebaria, Robert B. Quast, Alice E. Berizzi, Giuseppe Cannone, Kutti R. Vinothkumar, Chia-Ying Huang, Chady Nasrallah, Guillaume Lebon, Julie Briot, Joan Font-Ingles, Karine Rottier
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Reports, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩
Cell Reports, Elsevier Inc, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Reports, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩
Summary Metabotropic glutamate receptors (mGluRs) are dimeric G-protein-coupled receptors activated by the main excitatory neurotransmitter, L-glutamate. mGluR activation by agonists binding in the venus flytrap domain is regulated by positive (PAM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605603c382f708216045efdd1bc23c48
https://hal.archives-ouvertes.fr/hal-03340751/document
https://hal.archives-ouvertes.fr/hal-03340751/document
Autor:
Sabrina M. de Munnik, Iwan J. P. de Esch, Maikel Wijtmans, Shanliang Sun, Henry F. Vischer, Niels J Hauwert, Tamara A. M. Mocking, Prashanna Vijayachandran, Xavier Gómez-Santacana, Rob Leurs
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2509-2523 (2019)
Beilstein Journal of Organic Chemistry, 15, 2509-2523. Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
Gómez-Santacana, X, De Munnik, S M, Mocking, T A M, Hauwert, N J, Sun, S, Vijayachandran, P, De Esch, I J P, Vischer, H F, Wijtmans, M & Leurs, R 2019, ' A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light ', Beilstein Journal of Organic Chemistry, vol. 15, pp. 2509-2523 . https://doi.org/10.3762/bjoc.15.244
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2509-2523 (2019)
Beilstein Journal of Organic Chemistry, 15, 2509-2523. Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
Gómez-Santacana, X, De Munnik, S M, Mocking, T A M, Hauwert, N J, Sun, S, Vijayachandran, P, De Esch, I J P, Vischer, H F, Wijtmans, M & Leurs, R 2019, ' A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light ', Beilstein Journal of Organic Chemistry, vol. 15, pp. 2509-2523 . https://doi.org/10.3762/bjoc.15.244
We report a detailed structure–activity relationship for the scaffold of VUF16216, a compound we have previously communicated as a small-molecule efficacy photoswitch for the peptidergic chemokine GPCR CXCR3. A series of photoswitchable azobenzene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b9330a3b176b3d6bf2470ee88497c3
https://research.vu.nl/en/publications/99a68173-7b38-4cae-81e4-4b26868e58c2
https://research.vu.nl/en/publications/99a68173-7b38-4cae-81e4-4b26868e58c2
Autor:
Serena Notartomaso, Nico Antenucci, Mariacristina Mazzitelli, Xavier Rovira, Serena Boccella, Flavia Ricciardi, Francesca Liberatore, Xavier Gomez-Santacana, Tiziana Imbriglio, Milena Cannella, Charleine Zussy, Livio Luongo, Sabatino Maione, Cyril Goudet, Giuseppe Battaglia, Amadeu Llebaria, Ferdinando Nicoletti, Volker Neugebauer
Publikováno v:
eLife, Vol 13 (2024)
We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain. Optical activation of systemic JF-NP-26, a caged, normally inactive, negative allosteric modulator (NAM) of mGl
Externí odkaz:
https://doaj.org/article/7992b22d74894ac98d325b25e79626e5