Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Xavier Espanel"'
Publikováno v:
Methods. 35:64-72
This section provides detailed protocols for peptide synthesis on membrane (SPOT) and describes the application of this technology to protein tyrosine phosphatase (PTPs) substrate selectivity studies. Applications include PTP binding and dephosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc5853380b9920e9bcbc4278981fa83
https://doi.org/10.1016/j.ymeth.2004.07.009
https://doi.org/10.1016/j.ymeth.2004.07.009
Autor:
Sébastien Wälchli, Rob Hooft van Huijsduijnen, Xavier Espanel, Gianni Cesareni, Axel Harrenga, Mario Rossi
Publikováno v:
Journal of Biological Chemistry. 279:311-318
Protein tyrosine phosphatases (PTPs) play important, highly dynamic roles in signaling. Currently about 90 different PTP genes have been described. The enzymes are highly regulated at all levels of expression, and it is becoming increasingly clear th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16278da023dca9592ca09fae33d02f16
https://doi.org/10.1074/jbc.m307617200
https://doi.org/10.1074/jbc.m307617200
Autor:
Rob Hooft van Huijsduijnen, Fabrizio Arigoni, Ger J. Strous, Christian Pasquali, Xavier Espanel, Mireille Guerrier, Sébastien Wälchli, Marie Laure Curchod
Publikováno v:
Molecular Endocrinology. 17:2228-2239
Protein tyrosine phosphatases (PTPs) play key roles in switching off tyrosine phosphorylation cascades, such as initiated by cytokine receptors. We have used substrate-trapping mutants of a large set of PTPs to identify members of the PTP family that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07b37f9fac3b629468780768fc3e48f
https://doi.org/10.1210/me.2003-0011
https://doi.org/10.1210/me.2003-0011
Autor:
Xavier Espanel, Marius Sudol
Publikováno v:
Journal of Biological Chemistry. 276:14514-14523
To understand the role of the Yes-associated protein (YAP), binding partners of its WW1 domain were isolated by a yeast two-hybrid screen. One of the interacting proteins was identified as p53-binding protein-2 (p53BP-2). YAP and p53BP-2 interacted i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c202732f29471f451a8e9190f7064c98
https://doi.org/10.1074/jbc.m008568200
https://doi.org/10.1074/jbc.m008568200
A Single Point Mutation in a Group I WW Domain Shifts Its Specificity to That of Group II WW Domains
Autor:
Marius Sudol, Xavier Espanel
Publikováno v:
Journal of Biological Chemistry. 274:17284-17289
WW domains can be divided into three groups based on their binding specificity. By random mutagenesis, we switched the specificity of the Yes-associated protein (YAP) WW1 domain, a Group I WW domain, to that of the FE65 WW domain, which belongs to Gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bccd28530a06d1dd2ad7a1ab5375d90
https://doi.org/10.1074/jbc.274.24.17284
https://doi.org/10.1074/jbc.274.24.17284
Publikováno v:
Oncogene. 17:585-594
E2F-1 is the prototype of a family of transcription factors playing a central role in the control of cell proliferation and apoptosis. E2F DNA binding activity is down-regulated during cellular differentiation, which is correlated with cell division
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c4e8897dc74e37753d40eec852f5c4
https://doi.org/10.1038/sj.onc.1201962
https://doi.org/10.1038/sj.onc.1201962
Autor:
Anne Soude, Vanessa Adarbes, Severine Estevez, Xavier Espanel, Benaïssa Boubia, Nathalie Urban, Claudia Fromond, Bruno Loillier, Philippe Masson, Frederic Bell, Stephanie Bocart, Christian Montalbetti, Pierre Broqua
Publikováno v:
Cancer Research. 76:4524-4524
Multiple myeloma (MM) is a plasma cell malignancy which accounts for approximately 10% of hematologic malignancies. Despite the introduction of new therapeutic agents, MM remains incurable and nearly all patients ultimately relapse. About 20% of MM a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22671d41f5e51d1ea6b5624393d10aeb
https://doi.org/10.1158/1538-7445.am2016-4524
https://doi.org/10.1158/1538-7445.am2016-4524
Autor:
Laurent Chene, Pierre Broqua, Philippe Masson, Claudia Fromond, Benaïssa Boubia, Christian Montalbetti, Xavier Espanel
Publikováno v:
Cancer Research. 75:99-99
Epigenetic processes control gene expression and play a major role in cell proliferation, survival and differentiation. Dysregulation of epigenetic mechanisms may lead to alterations in gene expression, resulting in cellular transformation and malign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab9e6fdf02fb2b778deff83542c823b4
https://doi.org/10.1158/1538-7445.am2015-99
https://doi.org/10.1158/1538-7445.am2015-99
Autor:
Claudia Fromond, Xavier Espanel, Benaïssa Boubia, Laurent Chene, Anne Soude, Pierre Broqua, Philippe Masson, Christian Montalbetti
Publikováno v:
Cancer Research. 75:105-105
Multiple myeloma (MM) is a plasma cell malignancy which accounts for approximately 10% of hematologic malignancies. Despite the introduction of new therapeutic agents, MM remains incurable and nearly all patients ultimately relapse. About 20% of MM a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18dd27d4b19a3001927e36c7c349c5dd
https://doi.org/10.1158/1538-7445.am2015-105
https://doi.org/10.1158/1538-7445.am2015-105
Publikováno v:
Biochemical and biophysical research communications. 331(2)
Sap-1/PTPRH, a receptor protein tyrosine phosphatase (RPTP), is a ubiquitously expressed enzyme that is upregulated in human gastrointestinal cancers. Using both chemical cross-linkers and co-immunoprecipitation we show that overexpressed full-length
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae2bddab0da5afd37aa724bccc619e7
https://pubmed.ncbi.nlm.nih.gov/15850787
https://pubmed.ncbi.nlm.nih.gov/15850787