Výsledky vyhledávání - "Xavier Elduque"

On-Resin Conjugation of Diene–Polyamides and Maleimides via Diels–Alder Cycloaddition

Autor: Anna Grandas, Xavier Elduque, Enrique Pedroso, Omar Brun

Publikováno v: The Journal of Organic Chemistry. 80:6093-6101

The reaction between maleimides and resin-linked diene-polyamides allows the latter to be used in the preparation of conjugates. Conjugation takes place by reacting the insoluble, hydrophobic diene component either with water-soluble dienophiles or w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9208abef4f094e168e0fc9c8adbe7725
https://doi.org/10.1021/acs.joc.5b00592

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Local RNA flexibility perturbation of the IRES element induced by a novel ligand inhibits viral RNA translation

Autor: Alejandro Trapote, Jorge Ramajo, Encarnación Martínez-Salas, Anna Grandas, Gloria Lozano, Jordi Robles, Xavier Elduque, Enrique Pedroso

Publikováno v: RNA Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname

The internal ribosome entry site (IRES) element located at the 5’untranslated genomic region of various RNA viruses mediates cap-independent initiation of translation. Picornavirus IRES activity is highly dependent on both its structural organizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7903cafaa80bbe845c1fdb21a085e357
https://pubmed.ncbi.nlm.nih.gov/25775053

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Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols

Autor: Anna Grandas, David Cornu, Xavier Elduque, Aubérie Parent, Jean-Pierre Le Caer, Benoît D'Autréaux, Michel B. Toledano, Laura Belot

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2014, 6, pp.5686
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname

International audience; Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis. In mammals, the primary steps of Fe-S clu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695b23563a52287f0d3463f50e8de828
https://hal.archives-ouvertes.fr/hal-01111365

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Orthogonal protection of peptides and peptoids for cyclization by the thiol-ene reaction and conjugation

Autor: Xavier Elduque, Enrique Pedroso, Anna Grandas

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona

Cyclic peptides and peptoids were prepared using the thiol-ene Michael-type reaction. The linear precursors were provided with additional functional groups allowing for subsequent conjugation: an orthogonally protected thiol, a protected maleimide, o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119767778ab8809d111a9e94994ce783
http://hdl.handle.net/2445/53528

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Straightforward synthesis of cyclic and bicyclic peptides

Autor: Xavier Elduque, Anna Grandas, Enrique Pedroso

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona

Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38ff577f9e995e431501ce666afc339
https://pubmed.ncbi.nlm.nih.gov/23570412

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Protected maleimide building blocks for the decoration of peptides, peptoids and peptide nucleic acids

Autor: Kapil Sharma, Enrique Pedroso, Xavier Elduque, Albert Sánchez, Anna Grandas

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona

Monomers allowing for the introduction of [2,5-dimethylfuran]-protected maleimides into polyamides such as peptides, peptide nucleic acids, and peptoids were prepared, as well as the corresponding oligomers. Suitable maleimide deprotection conditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167f9d9f3e52caadc47670314506ef2c
http://hdl.handle.net/2445/49423

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Attachment of Nitroxide Spin Labels to Nucleic Acids for EPR

Autor: Olga Romainczyk, Joachim W. Engels, Xavier Elduque

Publikováno v: Current Protocols in Nucleic Acid Chemistry

In addition to X-ray, NMR, and FRET, electron paramagnetic resonance (EPR) can be applied to elucidate the structure of different macromolecular systems and determine local surroundings of paramagnetic centers in DNA and RNA. This technique permits s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb6d6645167df94154f5fc3c0cf1d60
https://doi.org/10.1002/0471142700.nc0717s49

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Akademický článek

Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids.

Autor: Paris, Clément¹ clementparis@ub.edu, Brun, Omar¹ o.brun@ub.edu, Pedroso, Enrique¹ epedroso@ub.edu, Grandas, Anna¹ anna.grandas@ub.edu

Publikováno v: Molecules. Apr2015, Vol. 20 Issue 4, p6389-6408. 20p. 17 Diagrams.

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Akademický článek

Local RNA flexibility perturbation of the IRES element induced by a novel ligand inhibits viral RNA translation.

Autor: Lozano, Gloria, Trapote, Alejandro, Ramajo, Jorge, Elduque, Xavier, Grandas, Anna, Robles, Jordi, Pedroso, Enrique, Martínez-Salas, Encarnación

Publikováno v: RNA Biology; May2015, Vol. 12 Issue 5, p555-568, 14p

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