Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Xavier Deupi"'
Autor:
Oliver Tejero, Filip Pamula, Mitsumasa Koyanagi, Takashi Nagata, Pavel Afanasyev, Ishita Das, Xavier Deupi, Mordechai Sheves, Akihisa Terakita, Gebhard F. X. Schertler, Matthew J. Rodrigues, Ching-Ju Tsai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Opsins are G protein-coupled receptors (GPCRs) that have evolved to detect light stimuli and initiate intracellular signaling cascades. Their role as signal transducers is critical to light perception across the animal kingdom. Opsins covale
Externí odkaz:
https://doaj.org/article/09af03e50c8841df8ba7999da291580f
Autor:
Darja Beyer, Christian Vaccarin, Xavier Deupi, Ana Katrina Mapanao, Susan Cohrs, Fan Sozzi-Guo, Pascal V. Grundler, Nicholas P. van der Meulen, Jinling Wang, Matthias Tanriver, Jeffrey W. Bode, Roger Schibli, Cristina Müller
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Purpose The angiotensin converting enzyme-2 (ACE2)—entry receptor of SARS-CoV-2—and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis. Potential changes in ACE2 expressi
Externí odkaz:
https://doaj.org/article/ad4f974295474f0392325fbd07ff6ab8
Autor:
Raphael S. Haider, Edda S. F. Matthees, Julia Drube, Mona Reichel, Ulrike Zabel, Asuka Inoue, Andy Chevigné, Cornelius Krasel, Xavier Deupi, Carsten Hoffmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here the authors present improved intramolecular sensors for β-arrestin2 and 1, which enable assessment of conformational changes of both isoforms in living cells. These reveal that the same GPCR induces differential conformational rearrangements th
Externí odkaz:
https://doaj.org/article/c788b6ac74db47fe8176035c251fe6d0
Autor:
Daniel Mayer, Fred F. Damberger, Mamidi Samarasimhareddy, Miki Feldmueller, Ziva Vuckovic, Tilman Flock, Brian Bauer, Eshita Mutt, Franziska Zosel, Frédéric H. T. Allain, Jörg Standfuss, Gebhard F. X. Schertler, Xavier Deupi, Martha E. Sommer, Mattan Hurevich, Assaf Friedler, Dmitry B. Veprintsev
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Here, authors use a library of synthetic phosphopeptide analogues of the GPCR rhodopsin C
Externí odkaz:
https://doaj.org/article/3fb017c511b74ac5b642a4f342d8976b
Autor:
Ching-Ju Tsai, Jacopo Marino, Ricardo Adaixo, Filip Pamula, Jonas Muehle, Shoji Maeda, Tilman Flock, Nicholas MI Taylor, Inayatulla Mohammed, Hugues Matile, Roger JP Dawson, Xavier Deupi, Henning Stahlberg, Gebhard Schertler
Publikováno v:
eLife, Vol 8 (2019)
One of the largest membrane protein families in eukaryotes are G protein-coupled receptors (GPCRs). GPCRs modulate cell physiology by activating diverse intracellular transducers, prominently heterotrimeric G proteins. The recent surge in structural
Externí odkaz:
https://doaj.org/article/e771e8ad582e45b493b49c84fa5cd9a3
Autor:
José Carlos Gómez Tamayo, Mireia Olivella, Santiago Ríos, Marlous Hoogstraat, Angel Gonzalez, Eduardo Mayol, Xavier Deupi, Mercedes Campillo, Arnau Cordomí
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199843 (2018)
G protein-coupled receptors (GPCRs) are one of the largest protein families in mammals. They mediate signal transduction across cell membranes and are important targets for the pharmaceutical industry. The G Protein-Coupled Receptors-Sequence Analysi
Externí odkaz:
https://doaj.org/article/4d2df72786e54bdaa66f5f592626f074
Autor:
Andrea Koenen, Aaron Babendreyer, Julian Schumacher, Tobias Pasqualon, Nicole Schwarz, Anke Seifert, Xavier Deupi, Andreas Ludwig, Daniela Dreymueller
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173486 (2017)
The CXC-chemokine receptor 6 (CXCR6) is a class A GTP-binding protein-coupled receptor (GPCRs) that mediates adhesion of leukocytes by interacting with the transmembrane cell surface-expressed chemokine ligand 16 (CXCL16), and also regulates leukocyt
Externí odkaz:
https://doaj.org/article/115ca485f7a345298ec6c674dc18ccac
Autor:
Rajesh Jayachandran, Xiaolong Liu, Somdeb Bosedasgupta, Philipp Müller, Chun-Lei Zhang, Despina Moshous, Vera Studer, Jacques Schneider, Christel Genoud, Catherine Fossoud, Frédéric Gambino, Malik Khelfaoui, Christian Müller, Deborah Bartholdi, Helene Rossez, Michael Stiess, Xander Houbaert, Rolf Jaussi, Daniel Frey, Richard A Kammerer, Xavier Deupi, Jean-Pierre de Villartay, Andreas Lüthi, Yann Humeau, Jean Pieters
Publikováno v:
PLoS Biology, Vol 12, Iss 3, p e1001820 (2014)
Cognitive and behavioral disorders are thought to be a result of neuronal dysfunction, but the underlying molecular defects remain largely unknown. An important signaling pathway involved in the regulation of neuronal function is the cyclic AMP/Prote
Externí odkaz:
https://doaj.org/article/5f217f7498134941886d3e2799f2c271
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23815 (2011)
The important and diverse biological functions of β-adrenergic receptors (βARs) have promoted the search for compounds to stimulate or inhibit their activity. In this regard, unraveling the molecular basis of ligand binding/unbinding events is esse
Externí odkaz:
https://doaj.org/article/bff93babe41e46a8830e3868ef289cff
Autor:
Asvin KK Lakkaraju, Oliver Tejero, Ramon Guixà-González, Elena De Cecco, Martina Jungo, Ching-Ju Tsai, Rocco Mastromartino, Jacopo Marino, Xavier Deupi, Simone Hornemann, Gebhard FX Schertler, Adriano Aguzzi
In prion diseases, the cellular prion protein PrPCis converted into aggregates of PrPSc, leading to profound neurotoxicity through largely unknown mechanisms. Here we report that the cellular prion protein PrPCacts as an antagonist of the adhesion G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3b94225a9986ef328bbe56464ef7427
https://doi.org/10.1101/2023.04.29.538801
https://doi.org/10.1101/2023.04.29.538801