Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Xavier Caignet"'
1
Data from Preclinical Activity of Ribociclib in Squamous Cell Carcinoma of the Head and Neck
Autor: Jean-Pascal Machiels, Didier Vertommen, Pierre P. Roger, Sébastien Pyr dit Ruys, Xavier Caignet, Mariama El Baroudi, Sandra Schmitz, Gabrielle van Caloen
Cell-cycle pathway impairments resulting in CDK4 and 6 activation are frequently observed in human papillomavirus (HPV)-negative squamous cell carcinoma of the head and neck (SCCHN). We investigated the activity of ribociclib, a CDK4/6 inhibitor, in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42a8f20df99fa36301cd01860b022f3
https://doi.org/10.1158/1535-7163.c.6543094.v1
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3
Preclinical evaluation of the association of the cyclin-dependent kinase 4/6 inhibitor, ribociclib, and cetuximab in squamous cell carcinoma of the head and neck
Autor: Sébastien Pyr dit Ruys, Jean Pascal Machiels, Gabrielle van Caloen, Sandra Schmitz, Didier Vertommen, Antonella Mendola, Xavier Caignet, Pierre P. Roger, Cédric van Marcke
Publikováno v: Cancers (Basel), 13 (6
Cancers
Cancers, Vol. 13, no.6, p. 1251 (2021)
Volume 13
Issue 6
Cancers, Vol 13, Iss 1251, p 1251 (2021)
Epidermal growth factor receptor (EGFR) overexpression is observed in 90% of human papillomavirus (HPV)-negative squamous cell carcinomas of the head and neck (SCCHN). Cell cycle pathway impairments resulting in cyclin-dependent kinase (CDK) 4 and 6
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b15a51587cc7ae066c730fdcabdfbe
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/321103
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4
Preclinical Activity of Ribociclib in Squamous Cell Carcinoma of the Head and Neck
Autor: Xavier Caignet, Sébastien Pyr dit Ruys, Sandra Schmitz, Mariama El Baroudi, Pierre P. Roger, Jean Pascal Machiels, Gabrielle van Caloen, Didier Vertommen
Publikováno v: Molecular cancer therapeutics, Vol. 19, no. 3, p. 777-789 (2020)
Molecular cancer therapeutics
Cell cycle pathway impairments resulting in cyclin-dependent kinase (CDK) 4 and 6 activation are frequently observed in human papillomavirus (HPV)-negative squamous cell carcinoma of the head and neck (SCCHN). We investigated the activity of ribocicl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54b333d7586c4f481e4ae1338f331a2
https://hdl.handle.net/2078.1/229496
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5
Metabolic imaging using hyperpolarized pyruvate-lactate exchange assesses response or resistance to the EGFR inhibitor cetuximab in patient-derived HNSCC xenografts
Autor: Xavier Caignet, Bénédicte F. Jordan, Olivier Feron, Patrice D. Cani, Stefania Acciardo, Rose-Marie Goebbels, Lionel Mignion, Cyril Corbet, Florian Gourgue, Sandra Schmitz, Jean-Pascal Machiels, Caroline Bouzin, Nicolas Joudiou
Publikováno v: Clinical cancer research, Vol. 15, no. 26(8), p. 1932-1943 (2020)
Purpose: Optimal head and neck squamous cell carcinoma (HNSCC) patient selection for anti–EGFR-based therapy remains an unmet need since only a minority of patients derive long-term benefit from cetuximab treatment. We assessed the ability of state
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff57f618e6344b5d623dad60e8687b9
https://hdl.handle.net/2078.1/224027
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7
Liquid biopsy for mutational profiling of locoregional recurrent and/or metastatic head and neck squamous cell carcinoma
Autor: Antonella Mendola, Xavier Caignet, Rose-Marie Goebbels, Nisha Limaye, Jean-Pascal Machiels, Raphaël Helaers, Kyril Wittouck, Jérôme Ambroise, Cédric van Marcke, Miikka Vikkula, R. Galot
Publikováno v: Oral oncology, Vol. 104, p. 104631 (2020)
The molecular landscape of head and neck squamous cell carcinoma (HNSCC) harbors potentially actionable genomic alterations. We aimed to study the utility of liquid biopsy to (i) characterize the mutational landscape of recurrent/metastatic HNSCC usi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa51affddd2256c2832fc74eed7056ec
https://doi.org/10.1016/j.oraloncology.2020.104631
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8
Liquid biopsy for mutational profiling of locoregional recurrent and/or metastatic squamous cell carcinoma of the head and neck
Autor: Nisha Limaye, K. Wittouck, Miikka Vikkula, C. Van Marcke de Lummen, Raphaël Helaers, Antonella Mendola, Xavier Caignet, Jérôme Ambroise, J.-P. Machiels, R. Galot, Rose-Marie Goebbels
Publikováno v: Annals of Oncology. 30:v468-v469
Background Circulating tumor DNA (ctDNA) is a minimally-invasive technique to profile the tumor genome in different cancers but is still underexplored in squamous cell carcinoma of the head and neck (SCCHN). Our aim was to study the relevance of muta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a4e7eb88be2ebdbdcb037040b4e6f31
https://doi.org/10.1093/annonc/mdz252.049
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