Výsledky vyhledávání - "Xavier Cañas"

Akademický článek

Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression

Autor: Laura Marruecos, Joan Manils, Cristina Moreta, Diana Gómez, Ingrid Filgaira, Anna Serafin, Xavier Cañas, Lluís Espinosa, Concepció Soler

Publikováno v: Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)

Abstract Dose of Trp53, the main keeper of genome stability, influences tumorigenesis; however, the causes underlying and driving tumorigenesis over time by the loss of a single p53 allele are still poorly characterized. Here, we found that single p5

Externí odkaz: https://doaj.org/article/36f5ec065d8846e28b72cd7234991a5f

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Akademický článek

Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart.

Autor: Maria Cardona, Juan Antonio López, Anna Serafín, Anthony Rongvaux, Javier Inserte, David García-Dorado, Richard Flavell, Marta Llovera, Xavier Cañas, Jesús Vázquez, Daniel Sanchis

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0131411 (2015)

Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles are being discovered. The heart expresses caspases only during development, suggesting they contribute to the organ maturation process. Therefore, we aimed at ide

Externí odkaz: https://doaj.org/article/7b0ee7ead6124cd094228c2fbc76412f

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Akademický článek

EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes.

Autor: Jisheng Zhang, Junmei Ye, Albert Altafaj, Maria Cardona, Núria Bahi, Marta Llovera, Xavier Cañas, Stuart A Cook, Joan X Comella, Daniel Sanchis

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17998 (2011)

Mitochondrial dysfunction, caspase activation and caspase-dependent DNA fragmentation are involved in cell damage in many tissues. However, differentiated cardiomyocytes repress the expression of the canonical apoptotic pathway and their death during

Externí odkaz: https://doaj.org/article/2c71090ab483452891e46a4ee5bb5b5a

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Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression

Autor: Xavier Cañas, Diana Gómez, Laura Marruecos, Lluis Espinosa, Concepció Soler, Joan Manils, Anna Serafín, Cristina Moreta, Ingrid Filgaira

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death & Disease

Dose of Trp53, the main keeper of genome stability, influences tumorigenesis; however, the causes underlying and driving tumorigenesis over time by the loss of a single p53 allele are still poorly characterized. Here, we found that single p53 allele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973ea422b13a226bd9f9b4ec3cdf7dc7
http://hdl.handle.net/2445/176681

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Neurobehavioral characterization of Endonuclease G knockout mice reveals a new putative molecular player in the regulation of anxiety

Autor: Xavier Cañas, Joan X. Comella, Marta Cherubini, Jordi Alberch, Daniel Sanchis, Silvia Ginés, Albert Giralt

Publikováno v: Experimental Neurology. 247:122-129

Endonuclease G (EndoG) has been largely related with a role in the modulation of a caspase-independent cell death pathway in many cellular systems. However, whether this protein plays a specific role in the brain remains to be elucidated. Here we hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41508503412f87c2ca1e0fb893b4436c
https://doi.org/10.1016/j.expneurol.2013.03.028

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EndoG Knockout Mice Show Increased Brown Adipocyte Recruitment in White Adipose Tissue and Improved Glucose Homeostasis

Autor: Maria Vilà, Daniel Sanchis, Rosario Pardo, Natividad Blasco, Rafael Simó, Xavier Cañas, Daniel Beiroa, Josep A. Villena, Rubén Nogueiras

Publikováno v: Endocrinology. 157(10)

Brown adipose tissue (BAT) plays a central role in the regulation of whole-body energy and glucose homeostasis owing to its elevated capacity for lipid and glucose oxidation. The BAT thermogenic function, which is essential for the defense of body te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994fa24627d4d0770b82041d7e3dc8da
https://pubmed.ncbi.nlm.nih.gov/27547848

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Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease

Autor: Agnès Gruart, Carles Bosch, Jordi Duran, Xavier Cañas, Jordi Valles-Ortega, Isabel Saez, Eduardo Soriano, Joan J. Guinovart, José M. Delgado-García, Anna Serafín, Mar García-Rocha, Lluís Pujadas

Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine; Vol 3

Lafora disease (LD) is caused by mutations in either the laforin or malin gene. The hallmark of the disease is the accumulation of polyglucosan inclusions called Lafora Bodies (LBs). Malin knockout (KO) mice present polyglucosan accumulations in seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c374b0c42202741592ac0acfc8cd14
http://europepmc.org/articles/PMC3377110

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Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart

Autor: Richard A. Flavell, Daniel Sanchis, Anna Serafín, David Garcia-Dorado, Javier Inserte, Marta Llovera, Anthony Rongvaux, Xavier Cañas, Maria Cardona, Jesús Vázquez, Juan Antonio López

Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
PLoS ONE, Vol 10, Iss 6, p e0131411 (2015)
PLoS ONE
Repisalud
Instituto de Salud Carlos III (ISCIII)
Recercat. Dipósit de la Recerca de Catalunya
instname

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47687c738a534d99dfdac78de1d9dfdf
https://hdl.handle.net/20.500.12105/5400

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L'Eurocité basque Bayonne-Saint-Sébastien, une construction urbaine transfrontalière (The basque euro-city Bayonne San Sebastian, a transborder urban construction)

Autor: Xavier Cañas, Hélène Vélasco-Graciet

Publikováno v: Bulletin de l'Association de géographes français. 81:509-520

The institutional end of the borders inside the European Union since 1992 has generated a big trend to new transborder territories. Between the ideology of an Europe of the regions and the revival of an historical territory, the "Pays Basque " experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbac2d943b2a46f83d38cf475de38be
https://doi.org/10.3406/bagf.2004.2416

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Proinsulin C peptide obviates sympathetically mediated suppression of splenic lymphocyte activity in rats

Autor: Masayuki Saito, Shiki Okamoto, Kazuhiro Kimura, Xavier Cañas, Takanori Kitamura, Toshihide Yoshida

Publikováno v: Diabetologia. 43:1512-1517

Aims/hypothesis. To investigate whether proinsulin C peptide influences sympathetic nerve activity directly or indirectly through parasympathetic nerve activity. Methods. The proliferative response of splenic lymphocytes to Concanavalin A (ConA respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2a13c064473529d7c8e3b763b41133
https://doi.org/10.1007/s001250051562

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