Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Xavier Bofill-De Ros"'
Autor:
Xavier Bofill-De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 279-289 (2022)
The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we per
Externí odkaz:
https://doaj.org/article/323a20767c8b455ebfa77ffc7863939f
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors reveal insights into miRNA tailing specificity of TENTs and their effect on miRNA levels by combinatory KOs of TENT2, TUT4 and TUT7. They show uridylation is linked to TENT2 and identify non-redundant functions between TUT4 and TUT7.
Externí odkaz:
https://doaj.org/article/c66fdbe2ae7040d2a5ca5f3ebad26dc5
Autor:
Xavier Bofill-De Ros
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 543-544 (2023)
Externí odkaz:
https://doaj.org/article/5ce2ee27511a4bfbb2eee360929ae298
Autor:
Xavier Bofill-De Ros
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 498-500 (2022)
Externí odkaz:
https://doaj.org/article/78ba727b88d84df1b2d00a20b42dc54c
Autor:
Acong Yang, Tie-Juan Shao, Xavier Bofill-De Ros, Chuanjiang Lian, Patricia Villanueva, Lisheng Dai, Shuo Gu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
3′ end of microRNAs binds to the PAZ domain of Argonaute (AGO) proteins. Here the authors show that terminal nucleotidyltransferases TUT4/7 and exonuclease DIS3L2 induce tailing and decay of 3’ end exposed-microRNAs in AGO PAZ mutant expressing-
Externí odkaz:
https://doaj.org/article/cf79b8e7987b4e57af1d8a30458a8f70
Autor:
Xavier Bofill-De Ros
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 756-757 (2022)
Externí odkaz:
https://doaj.org/article/8b9fd535b53a4d8b9ad10b883c3ccf36
Autor:
Xavier Bofill-De Ros, Wojciech K. Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie-Juan Shao, Bruce A. Shapiro, Yun-Xing Wang, Shuo Gu
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 447-459.e4 (2019)
Summary: MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity. To understand how pri-miRNA sequence and structure influence Drosha cleavage, we studie
Externí odkaz:
https://doaj.org/article/ddfe0f6fd3994ce482d993e45c7ea9a6
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
MicroRNAs (miRNAs) are an abundant class of small non-coding RNA molecules (~22 nt) that can repress gene expression. Deregulation of certain miRNAs is widely recognized as a robust biomarker for many neoplasms, as well as an important player in tumo
Externí odkaz:
https://doaj.org/article/60ec2a7eb72940de9f7559b0e22c7568
Autor:
Jessica N. Hatton, Megan N. Frone, Hannah C. Cox, Stephanie B. Crowley, Susan Hiraki, Noriko N. Yokoyama, Noura S. Abul-Husn, James F. Amatruda, Michael J. Anderson, Xavier Bofill-De Ros, Ann G. Carr, Elizabeth C. Chao, Kenneth S. Chen, Shuo Gu, Cecilia Higgs, Jerry Machado, Deborah Ritter, Kris Ann P. Schultz, Emily R. Soper, Mona K. Wu, Jessica L. Mester, Jung Kim, William D. Foulkes, Leora Witkowski, Douglas R. Stewart
Publikováno v:
Human Mutation.
Germline pathogenic variants in DICER1 predispose individuals to develop a variety of benign and malignant tumors. Accurate variant curation and classification are essential for reliable diagnosis of DICER1-related tumor predisposition and the identi
Autor:
Acong Yang, Shuo Gu, Bao Tran, Xavier Bofill-De Ros, Lisheng Dai, Sean Chen, Chuanjiang Lian, Tony Shi, Lillian Hallmark, Yongmei Zhao, Howard Crouch
Publikováno v:
RNA Biol
MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22-nucleotide (nt) in length that collectively regulate more than 60% of coding genes. Aberrant miRNA expression is associated with numerous diseases, including cancer. miRNA biogenesis is