ClusterCAD 2.0: an updated computational platform for chimeric type I polyketide synthase and nonribosomal peptide synthetase design

Autor: Xavier B Tao, Sarah LaFrance, Yifei Xing, Alberto A Nava, Hector Garcia Martin, Jay D Keasling, Tyler W H Backman

Publikováno v: Tao, X B, LaFrance, S, Xing, Y, Nava, A A, Martin, H G, Keasling, J D & Backman, T W H 2023, ' ClusterCAD 2.0: an updated computational platform for chimeric type I polyketide synthase and nonribosomal peptide synthetase design ', Nucleic Acids Research, vol. 51, no. D1, gkac1075 . https://doi.org/10.1093/nar/gkac1075

Megasynthase enzymes such as type I modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) play a central role in microbial chemical warfare because they can evolve rapidly by shuffling parts (catalytic domains) to produce n

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https://pubmed.ncbi.nlm.nih.gov/36416273