Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Xavier, Vigé"'
Autor:
André Malanda, Pierre-Yves Abécassis, Pascal Barnéoud, Pascale Brunel, Véronique Taupin, Xavier Vigé, Dominique Lesuisse
Publikováno v:
Data in Brief, Vol 27, Iss , Pp - (2019)
This article describes the chemical synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel Nurr1/NOT agonist. It is meant as a support to an article recently published in Bioorganic and Medicinal
Externí odkaz:
https://doaj.org/article/05051d3cfbe34e0dbf7765b754751143
Autor:
Sandrine Roche, Zsolt Bocskei, Michel Didier, Anne-Céline Le Fèvre, Cécile Orsini, Lucile Hoet, Jean-Claude Guillemot, Tamara Slavnic, Corinne Rocher, Aimo Kannt, Xavier Vigé, Vincent Mikol, Marie-Dominique Bock, Agnès Jacquet, Gilles Haussy, Valérie Martin, Marion Duriez
Publikováno v:
Journal of Clinical and Translational Hepatology
Background and Aims: To better understand nonalcoholic steatohepatitis (NASH) disease progression and to evaluate drug targets and compound activity, we undertook the development of an in vitro 3D model to mimic liver architecture and the NASH enviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28dbda09c771b8862ebc2d67273f4e6
http://europepmc.org/articles/PMC7782122
http://europepmc.org/articles/PMC7782122
Autor:
Corinne Lafon, Amélie Dommergue, Thomas Rooney, Dominique Lesuisse, Thy Phuong Hieu Luc, Anne Olivier, Pierre-Yves Abecassis, Luc Even, Véronique Taupin, Patrick Lardenois, Xavier Vigé, Marie-Noëlle Castel, Florian Auger, Yannick Evanno, Andre Malanda, Marie-Claude Burgevin, Pascal Barneoud, Céline Cegarra, Antonio Almario, Joanna Tsi, Pascale Brunel, Jean-Francois Peyronel, Danielle De-Peretti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:929-932
In the course of a programme aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson’s disease, a few hits from high throughput screening were identified and characterized. A combined optimization pointed to a very narrow and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da24f03facfdd36275110ac060ed5915
https://doi.org/10.1016/j.bmcl.2019.01.024
https://doi.org/10.1016/j.bmcl.2019.01.024
Autor:
Dominique Lesuisse, Pierre-Yves Abecassis, Andre Malanda, Pascale Brunel, Véronique Taupin, Xavier Vigé, Pascal Barneoud
Publikováno v:
Data in Brief, Vol 27, Iss, Pp-(2019)
Data in Brief
Data in Brief
This article describes the chemical synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel Nurr1/NOT agonist. It is meant as a support to an article recently published in Bioorganic and Medicinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94abed80b19cfd09a901811d7c560040
http://www.sciencedirect.com/science/article/pii/S2352340919304111
http://www.sciencedirect.com/science/article/pii/S2352340919304111
Publikováno v:
Journal of applied toxicology : JAT. 37(12)
The use of colloidal silica nanoparticles and sub-microparticles (SiPs) have been considered a very interesting strategy for drug delivery applications. In the present study, we have focused our attention on the suitability of these nanomaterials as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9417e036ecb095e73a65450ddb12d034
https://pubmed.ncbi.nlm.nih.gov/28744887
https://pubmed.ncbi.nlm.nih.gov/28744887
Autor:
Mark D. Black, Denis Boulay, Rosy Sher, Guy Griebel, Sukhveen Sahni, Robert E. Featherstone, Franck Slowinski, Sathapana Kongsamut, Vanessa Naimoli, C. Desvignes, Kosley Raymond W, Geoffrey B. Varty, Xavier Vigé, Olivier Bergis, Lisa Potestio, Philippe Pichat, Henry Defex
Publikováno v:
Scientific Reports
Normalization of altered glutamate neurotransmission through activation of the mGluR2 has emerged as a new approach to treat schizophrenia. These studies describe a potent brain penetrant mGluR2 positive allosteric modulator (PAM), SAR218645. The com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b3deb4b4ce55cdb0ce6ba96cb6cdcf
https://doi.org/10.1038/srep35320
https://doi.org/10.1038/srep35320
Autor:
Georges Kalouche, Annick Coste, Cécile Orsini, Thomas Debeir, William Rostène, Céline Boucher, Xavier Vigé, Christophe Baudouin, Laurent Debussche
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2016, ⟨10.1016/j.bbamcr.2016.06.008⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2016, ⟨10.1016/j.bbamcr.2016.06.008⟩
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2016, ⟨10.1016/j.bbamcr.2016.06.008⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2016, ⟨10.1016/j.bbamcr.2016.06.008⟩
International audience; E-prostanoid receptor subtype 2 (EP2) agonists are currently under clinical development as hypotensive agents for the treatment of ocular hypertension. However, the effects of EP2 receptor agonists on trabecular meshwork (TM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705a5dcb4965631164180075b6dcc38f
https://hal.sorbonne-universite.fr/hal-01338443
https://hal.sorbonne-universite.fr/hal-01338443
Autor:
Stéphane Mélik-Parsadaniantz, Michael Bakria, Thomas Debeir, William Rostène, Fanny Beguier, Caroline Leriche, Xavier Vigé, Georges Kalouche, Christophe Baudouin
Publikováno v:
Investigative ophthalmologyvisual science. 57(4)
Purpose Prostaglandin F2α analogues are the first-line medication for the treatment of ocular hypertension (OHT), and prostanoid EP2 receptor agonists are under clinical development for this indication. The goal of this study was to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1a308a2479d4f5bbe0110b36909bf6
https://pubmed.ncbi.nlm.nih.gov/27082296
https://pubmed.ncbi.nlm.nih.gov/27082296
Autor:
Bruno Biton, Guy Griebel, Caroline Cohen, Pascal George, Philippe Pichat, Mireille Sevrin, Genevieve Estenne-Bouhtou, Nancy Rogacki, C. Desvignes, Bernard Scatton, Patrick Avenet, Xavier Vigé, Jeanne Stemmelin, Olivier Bergis, Annick Coste, Denis Boulay, Christophe Lanneau, Jean Paul Terranova, Régis Steinberg, R. Alonso, Gihad Dargazanli, F. Oury-Donat
Publikováno v:
Pharmacology Biochemistry and Behavior. 91:47-58
On native human, rat and mouse glycine transporter-1(GlyT1), SSR130800 behaves as a selective inhibitor with IC50 values of 1.9, 5.3 and 6.8 nM, respectively. It reversibly blocked glycine uptake in mouse brain cortical homogenates, increased extrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6687966391f5ff03ce02d4870bfc9701
https://doi.org/10.1016/j.pbb.2008.06.009
https://doi.org/10.1016/j.pbb.2008.06.009
Autor:
Marc Williams Debono, Alistair Lochead, Dominique Françon, Annick Coste, Pascal George, Francoise Chesney, André Oblin, Raphaël Santamaria, Corinne Voltz, Patrick Granger, Danielle Godet, Olivier Bergis, Liliane Rouquier, Alain Nedelec, Georg Andrees Bohme, Bernard Scatton, Samir Jegham, Frederic Galli, Bruno Biton, Guy Griebel, Christiane Gueudet, Vincent Santucci, F. Oury-Donat, David I. Graham, Jacques Léonardon, François Besnard, Régis Steinberg, Frédéric Sgard, Josiane Souilhac, Olivier Curet, Xavier Vigé, Christophe Lanneau, Patrick Avenet
Publikováno v:
Neuropsychopharmacology. 32:1-16
In this paper, we report on the pharmacological and functional profile of SSR180711 (1,4-Diazabicyclo[3.2.2]nonane-4-carboxylic acid, 4-bromophenyl ester), a new selective alpha7 acetylcholine nicotinic receptor (n-AChRs) partial agonist. SSR180711 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259e28ed2f1b66d2920ae44ef537db33
https://doi.org/10.1038/sj.npp.1301189
https://doi.org/10.1038/sj.npp.1301189