Exploring metabolic anomalies in COVID-19 and post-COVID-19: a machine learning approach with explainable artificial intelligence

Autor: Juan José Oropeza-Valdez, Cristian Padron-Manrique, Aarón Vázquez-Jiménez, Xavier Soberon, Osbaldo Resendis-Antonio

Publikováno v: Frontiers in Molecular Biosciences, Vol 11 (2024)

The COVID-19 pandemic, caused by SARS-CoV-2, has led to significant challenges worldwide, including diverse clinical outcomes and prolonged post-recovery symptoms known as Long COVID or Post-COVID-19 syndrome. Emerging evidence suggests a crucial rol

Externí odkaz: https://doaj.org/article/61e4693ea256429397f3a82ea009f1dd

A Loss-of-Function Splice Acceptor Variant in

Autor: Josep M, Mercader, Rachel G, Liao, Avery D, Bell, Zachary, Dymek, Karol, Estrada, Taru, Tukiainen, Alicia, Huerta-Chagoya, Hortensia, Moreno-Macías, Kathleen A, Jablonski, Robert L, Hanson, Geoffrey A, Walford, Ignasi, Moran, Ling, Chen, Vineeta, Agarwala, María Luisa, Ordoñez-Sánchez, Rosario, Rodríguez-Guillen, Maribel, Rodríguez-Torres, Yayoi, Segura-Kato, Humberto, García-Ortiz, Federico, Centeno-Cruz, Francisco, Barajas-Olmos, Lizz, Caulkins, Sobha, Puppala, Pierre, Fontanillas, Amy L, Williams, Sílvia, Bonàs-Guarch, Chris, Hartl, Stephan, Ripke, Katherine, Tooley, Jacqueline, Lane, Carlos, Zerrweck, Angélica, Martínez-Hernández, Emilio J, Córdova, Elvia, Mendoza-Caamal, Cecilia, Contreras-Cubas, María E, González-Villalpando, Ivette, Cruz-Bautista, Liliana, Muñoz-Hernández, Donaji, Gómez-Velasco, Ulises, Alvirde, Brian E, Henderson, Lynne R, Wilkens, Loic, Le Marchand, Olimpia, Arellano-Campos, Laura, Riba, Maegan, Harden, Stacey, Gabriel, Hanna E, Abboud, Maria L, Cortes, Cristina, Revilla-Monsalve, Sergio, Islas-Andrade, Xavier, Soberon, Joanne E, Curran, Christopher P, Jenkinson, Ralph A, DeFronzo, Donna M, Lehman, Craig L, Hanis, Graeme I, Bell, Michael, Boehnke, John, Blangero, Ravindranath, Duggirala, Richa, Saxena, Daniel, MacArthur, Jorge, Ferrer, Steven A, McCarroll, David, Torrents, William C, Knowler, Leslie J, Baier, Noel, Burtt, Clicerio, González-Villalpando, Christopher A, Haiman, Carlos A, Aguilar-Salinas, Teresa, Tusié-Luna, Jason, Flannick, Suzanne B R, Jacobs, Lorena, Orozco, David, Altshuler, Jose C, Florez

Publikováno v: Diabetes

Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue to rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed and replicated g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4aa20a6b9960f114453820c8e8b3dcc6
https://pubmed.ncbi.nlm.nih.gov/28838971

Role of the phenylalanine 260 residue in defining product profile and alcoholytic activity of the α-amylase AmyA from Thermotoga maritima

Autor: Agustín López-Munguía, Juanita Yazmin Damián-Almazo, Gloria Saab-Rincón, Xavier Soberon-Mainero

Publikováno v: Biologia. 63:1035-1043

Some α-amylases besides catalyzing the hydrolysis of α-1,4 glycosidic bonds in starch are also capable of carrying out some transglycosylation activity. The importance of aromatic residues near the catalytic site in determining the ratio of these t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54f5f12464f4fbd76b7ab88ed706eb26
https://doi.org/10.2478/s11756-008-0170-4