Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer

Autor: Daniel Morales Borràs, Sara Verbandt, Markus Ausserhofer, Gregor Sturm, Jinyeong Lim, Gil Arasa Verge, Isaure Vanmeerbeek, Raquel S. Laureano, Jannes Govaerts, Jenny Sprooten, Yourae Hong, Rebecca Wall, Gert De Hertogh, Xavier Sagaert, Gabriele Bislenghi, André D’Hoore, Albert Wolthuis, Francesca Finotello, Woong-Yang Park, Stefan Naulaerts, Sabine Tejpar, Abhishek D. Garg

Publikováno v: Cell Discovery, Vol 9, Iss 1, Pp 1-30 (2023)

Abstract CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of immunotherapy against microsatellite stable (MSS) CRC is limited. Litt

Externí odkaz: https://doaj.org/article/b6bbbd98e72c4ea192406d7073bc5f95

Hemicolectomy versus appendectomy for patients with appendiceal neuroendocrine tumours 1–2 cm in size

Autor: Cédric Nesti, Konstantin Bräutigam, Marta Benavent, Laura Bernal, Hessa Boharoon, Johan Botling, Antonin Bouroumeau, Iva Brcic, Maximilian Brunner, Guillaume Cadiot, Maria Camara, Emanuel Christ, Thomas Clerici, Ashley K Clift, Hamish Clouston, Lorenzo Cobianchi, Jarosław B Ćwikła, Kosmas Daskalakis, Andrea Frilling, Rocio Garcia-Carbonero, Simona Grozinsky-Glasberg, Jorge Hernando, Valérie Hervieu, Johannes Hofland, Pernille Holmager, Frediano Inzani, Henning Jann, Paula Jimenez-Fonseca, Enes Kaçmaz, Daniel Kaemmerer, Gregory Kaltsas, Branislav Klimacek, Ulrich Knigge, Agnieszka Kolasińska-Ćwikła, Walter Kolb, Beata Kos-Kudła, Catarina Alisa Kunze, Stefania Landolfi, Stefano La Rosa, Carlos López López, Kerstin Lorenz, Maurice Matter, Peter Mazal, Claudia Mestre-Alagarda, Patricia Morales del Burgo, Els J M Nieveen van Dijkum, Kira Oleinikov, Lorenzo A Orci, Francesco Panzuto, Marianne Pavel, Marine Perrier, Henrik Mikael Reims, Guido Rindi, Anja Rinke, Maria Rinzivillo, Xavier Sagaert, Ilker Satiroglu, Andreas Selberherr, Alexander R Siebenhüner, Margot E T Tesselaar, Michael J Thalhammer, Espen Thiis-Evensen, Christos Toumpanakis, Timon Vandamme, José G van den Berg, Alessandro Vanoli, Marie-Louise F van Velthuysen, Chris Verslype, Stephan A Vorburger, Alessandro Lugli, John Ramage, Marcel Zwahlen, Aurel Perren, Reto M Kaderli

Publikováno v: The Lancet Oncology, 24(2), 187-194. Lancet Publishing Group
The lancet oncology

BACKGROUND Awareness of the potential global overtreatment of patients with appendiceal neuroendocrine tumours (NETs) of 1-2 cm in size by performing oncological resections is increasing, but the rarity of this tumour has impeded clear recommendation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863aa70c0a52eaaee09d624cc97c6163
https://pure.eur.nl/en/publications/80acd2b4-30e3-42f7-b9fd-20ec17986701

Data from PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development

Autor: Veerle Janssens, Anna Sablina, Jukka Westermarck, Peter Carmeliet, Mieke Dewerchin, Caroline Lambrecht, Dorien Haesen, Eline Miermans, Xavier Sagaert, Enrico Radaelli, Petar Kalev, Bob Meeusen, Ward Sents

Protein phosphatase 2A (PP2A) complexes counteract many oncogenic kinase pathways. In cancer cells, PP2A function can be compromised by several mechanisms, including sporadic mutations in its scaffolding A and regulatory B subunits or more frequently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8950295cdfe808286f29b699ff60f72
https://doi.org/10.1158/0008-5472.c.6509475

Table S2 from PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development

Autor: Veerle Janssens, Anna Sablina, Jukka Westermarck, Peter Carmeliet, Mieke Dewerchin, Caroline Lambrecht, Dorien Haesen, Eline Miermans, Xavier Sagaert, Enrico Radaelli, Petar Kalev, Bob Meeusen, Ward Sents

Antibodies used in this study.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5ee8932a8755282a41ec637f6b4a7d
https://doi.org/10.1158/0008-5472.22416168

Supplementary Table 1 from Hypoxia-Driven Gene Expression Is an Independent Prognostic Factor in Stage II and III Colon Cancer Patients

Autor: Jos van Pelt, Chris Verslype, André D'Hoore, Eric Van Cutsem, Bart De Moor, Xavier Sagaert, Dusan Popovic, Hannah van Malenstein, Daphne Hompes, Jeroen Dekervel

PDF file - 86KB, List of genes and RT-PCR assay IDs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c1e3dd506a7f74faa7ab68f7a610a9
https://doi.org/10.1158/1078-0432.22449140