Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Xavier, Nassif"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Protein phosphorylation is an integral part of many cellular processes, not only in eukaryotes but also in bacteria. The discovery of both prokaryotic protein kinases and phosphatases has created interest in generating antibacterial therapeu
Externí odkaz:
https://doaj.org/article/5a91c53812b74b23ac61e202d9003bca
Implantation of engineered human microvasculature to study human infectious diseases in mouse models
Autor:
Sophia Schönherr-Hellec, Eirini Chatzopoulou, Jean-Philippe Barnier, Yoann Atlas, Sébastien Dupichaud, Thomas Guilbert, Yves Dupraz, Julie Meyer, Catherine Chaussain, Caroline Gorin, Xavier Nassif, Stephane Germain, Laurent Muller, Mathieu Coureuil
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106286- (2023)
Summary: Animal models for studying human pathogens are crucially lacking. We describe the implantation in mice of engineered human mature microvasculature consisting of endothelial and perivascular cells embedded in collagen hydrogel that allows inv
Externí odkaz:
https://doaj.org/article/42dd2748dbfa4182b28a846f68f9536c
Autor:
Rishma Amarsy, David Trystram, Emmanuelle Cambau, Catherine Monteil, Sandra Fournier, Juliette Oliary, Helga Junot, Pierre Sabatier, Raphaël Porcher, Jérôme Robert, Vincent Jarlier, Guillaume Arlet, Laurence Armand Lefevre, Alexandra Aubry, Laurent Belec, Béatrice Bercot, Stéphane Bonacorsi, Vincent Calvez, Etienne Carbonnelle, Stéphane Chevaliez, Jean-Winoc Decousser, Constance Delaugerre, Diane Descamps, Florence Doucet-Populaire, Jean-Louis Gaillard, Antoine Garbarg- Chenon, Elyanne Gault, Jean-Louis Herrmann, Jérôme Le Goff, Jean-Christophe Lucet, Jean-Luc Mainardi, Anne-Geneviève Marcellin, Laurence Morand-Joubert, Xavier Nassif, Jean-Michel Pawlotsky, Anne-Marie Roque Afonso, Martin Rottman, Christine Rouzioux, Flore Rozenberg, François Simon, Nicolas Veziris, David Skurnik, Jean-Ralph Zahar, Guilene Barnaud, Typhaine Billard Pomares, Gaëlle Cuzon, Dominique Decré, Alexandra Doloy, Jean-Luc Donay, Laurence Drieux-Rouzet, Isabelle Durand, Agnès Ferroni, Vincent Fihman, Nicolas Fortineau, Camille Gomart, Nathalie Grall, Christelle Guillet Caruba, Françoise Jaureguy, Valérie Lalande, Luce Landraud, Véronique Leflon, Patricia Mariani, Liliana Mihaila, Didier Moissenet, Latifa Noussair, Isabelle Podglajen, Isabelle Poilane, Hélène Poupet, Emilie Rondinaud, Valérie Sivadon Tardy, Charlotte Verdet, Emmanuelle Vigier, Sophie Vimont Billarant
Publikováno v:
International Journal of Infectious Diseases, Vol 114, Iss , Pp 90-96 (2022)
Objectives: This study measured the impact of the first wave of COVID-19 pandemic (COVID-19) (March–April 2020) on the incidence of bloodstream infections (BSIs) at Assistance Publique – Hôpitaux de Paris (APHP), the largest multisite public hea
Externí odkaz:
https://doaj.org/article/dbe9193e72ae446ebaf008bb25bb9ab4
Autor:
Zoe Virion, Stéphane Doly, Kusumika Saha, Mireille Lambert, François Guillonneau, Camille Bied, Rebecca M. Duke, Pauline M. Rudd, Catherine Robbe-Masselot, Xavier Nassif, Mathieu Coureuil, Stefano Marullo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Meningococcus utilizes β-arrestin selective activation of endothelial cell β2 adrenergic receptor (β2AR) to cause meningitis in humans. Here authors report that Meningococcus triggers β2AR signaling by exerting forces on β2AR glycans that termin
Externí odkaz:
https://doaj.org/article/5266fe5b61d4428e97255621e2d00f9c
Autor:
Charles Vidal, Florence Moulin, Xavier Nassif, Louise Galmiche, Delphine Borgel, Alain Charbit, Capucine Picard, Jean-Paul Mira, Olivier Lortholary, Anne Jamet, Julie Toubiana
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-5 (2019)
Abstract Background Staphylococcus aureus has emerged as a leading cause of invasive severe diseases with a high rate of morbidity and mortality worldwide. The wide spectrum of clinical manifestations and outcome observed in staphylococcal illness ma
Externí odkaz:
https://doaj.org/article/db4bfc36de5a4086bfe130e8eb427910
Autor:
Jean-Philippe Barnier, Daniel Euphrasie, Olivier Join-Lambert, Mathilde Audry, Sophia Schonherr-Hellec, Taliah Schmitt, Sandrine Bourdoulous, Mathieu Coureuil, Xavier Nassif, Mohamed El Behi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009299 (2021)
Neisseria meningitidis (the meningococcus) remains a major cause of bacterial meningitis and fatal sepsis. This commensal bacterium of the human nasopharynx can cause invasive diseases when it leaves its niche and reaches the bloodstream. Blood-borne
Externí odkaz:
https://doaj.org/article/864a8c380c5e49d1960ec60cf1118830
Autor:
Anne Jamet, Marie Touchon, Bruno Ribeiro-Gonçalves, João André Carriço, Alain Charbit, Xavier Nassif, Mario Ramirez, Eduardo P. C. Rocha
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-12 (2017)
Abstract Background Polymorphic toxins (PTs) are multi-domain bacterial exotoxins belonging to distinct families that share common features in terms of domain organization. PTs are found in all major bacterial clades, including many toxic effectors o
Externí odkaz:
https://doaj.org/article/a81677a5fd8640d2a5c73054e7dec6eb
Autor:
Nawal Maïssa, Valentina Covarelli, Sébastien Janel, Beatrice Durel, Nandi Simpson, Sandra C. Bernard, Liliana Pardo-Lopez, Haniaa Bouzinba-Ségard, Camille Faure, Mark G.H. Scott, Mathieu Coureuil, Philippe C. Morand, Frank Lafont, Xavier Nassif, Stefano Marullo, Sandrine Bourdoulous
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Neisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength
Externí odkaz:
https://doaj.org/article/812ccd1878054e24ab2fafea122fa20e
Autor:
Mathilde Audry, Catherine Robbe-Masselot, Jean-Philippe Barnier, Benoit Gachet, Bruno Saubaméa, Alain Schmitt, Sophia Schönherr-Hellec, Renaud Léonard, Xavier Nassif, Mathieu Coureuil
Publikováno v:
mSphere, Vol 4, Iss 6 (2019)
ABSTRACT Neisseria meningitidis is an inhabitant of the nasopharynx, from which it is transmitted from person to person or disseminates in blood and becomes a harmful pathogen. In this work, we addressed colonization of the nasopharyngeal niche by fo
Externí odkaz:
https://doaj.org/article/d81ef51b21d74508b970f4b356236801
Autor:
Fanny Alby-Laurent, Cécile Lambe, Agnès Ferroni, Nadège Salvi, David Lebeaux, Morgane Le Gouëz, Martin Castelle, Florence Moulin, Xavier Nassif, Olivier Lortholary, Martin Chalumeau, Julie Toubiana
Publikováno v:
Frontiers in Pediatrics, Vol 6 (2019)
Introduction: Current international guidelines strongly recommend catheter removal in case of S. aureus central line-associated bloodstream infection (CLASBI), but a catheter salvage strategy may be considered in children given age-related specificit
Externí odkaz:
https://doaj.org/article/bfdf76917d6241c395b0545b99a5c244