Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Xavier, Gomis"'
Autor:
Danuta Mizgalska, Arturo Rodríguez-Banqueri, Florian Veillard, Mirosław Książęk, Theodoros Goulas, Tibisay Guevara, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis-Rüth
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Gram-negative bacteria from the Bacteroidota phylum possess a type-IX secretion system (T9SS) for protein secretion, which requires cargoes to have a C-terminal domain (CTD). Structurally analysed CTDs are from Porphyromonas gingivalis proteins RgpB,
Externí odkaz:
https://doaj.org/article/ad1a5dec84394926a6901eee7856ddc6
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Human α2-macroglobulin (hα2M) is a large homotetrameric protein involved in the broad inhibition of endopeptidases. Following cleavage within a bait region, hα2M undergoes stepwise transitions from its native, expanded, highly flexible, a
Externí odkaz:
https://doaj.org/article/6526f1aea2ab457dbd2a55a0cc407659
Autor:
Tamuka M. Chidyausiku, Soraia R. Mendes, Jason C. Klima, Marta Nadal, Ulrich Eckhard, Jorge Roel-Touris, Scott Houliston, Tibisay Guevara, Hugh K. Haddox, Adam Moyer, Cheryl H. Arrowsmith, F. Xavier Gomis-Rüth, David Baker, Enrique Marcos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The immunoglobulin domain framework of antibodies has been a long standing design challenge. Here, the authors describe design rules for tailoring these domains and show they can be accurately designed, de novo, with high stability and the ability to
Externí odkaz:
https://doaj.org/article/97a8dd6f14d04e56ae09b84b09e5515d
Autor:
Laura del Amo-Maestro, Soraia R. Mendes, Arturo Rodríguez-Banqueri, Laura Garzon-Flores, Marina Girbal, María José Rodríguez-Lagunas, Tibisay Guevara, Àngels Franch, Francisco J. Pérez-Cano, Ulrich Eckhard, F. Xavier Gomis-Rüth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Celiac disease is characterized by intolerance to gluten, a cereal protein. Here, the authors show that neprosin, a glutamate peptidase from the pitcher plant, efficiently cleaves gluten components under physiological conditions in vitro and in the g
Externí odkaz:
https://doaj.org/article/c97bf5c69b2542dc92e0df34d7aecee1
Autor:
Marta Palau, Estela Muñoz, Muriel F. Gusta, Nieves Larrosa, Xavier Gomis, Joan Gilabert, Benito Almirante, Victor Puntes, Robert Texidó, Joan Gavaldà
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT In view of the current increase and spread of antimicrobial resistance (AMR), there is an urgent need to find new strategies to combat it. This study had two aims. First, we synthesized highly monodispersed silver nanoparticles (AgNPs) of ap
Externí odkaz:
https://doaj.org/article/dcd0d598300a4b9ca265b4eb1f9a7ed9
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Bacillus subtilis is a commensal member of the human oral and gut microbiomes, which can become infectious to immunocompromised patients. It possesses a conjugative transposon, ICEBs1, which includes > 20 genes and can be passed by horizonta
Externí odkaz:
https://doaj.org/article/830e2548fb8f4549b252df8196fe1e8d
Autor:
Soraia R. Mendes, Ulrich Eckhard, Arturo Rodríguez-Banqueri, Tibisay Guevara, Peter Czermak, Enrique Marcos, Andreas Vilcinskas, F. Xavier Gomis-Rüth
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 534-544 (2022)
Aureolysin, a secreted metallopeptidase (MP) from the thermolysin family, functions as a major virulence factor in Staphylococcus aureus. No specific aureolysin inhibitors have yet been described, making this an important target for the development o
Externí odkaz:
https://doaj.org/article/1e0c32ae4f5848d6a20d93f2fff9494e
Autor:
Marta Palau, Estela Muñoz, Nieves Larrosa, Xavier Gomis, Ester Márquez, Oscar Len, Benito Almirante, Joan Gavaldà
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT There is currently an urgent need to find new strategies to tackle antimicrobial resistance and biofilm-related infections. This study has two aims. First, we evaluated the in vitro efficacy of hyperthermia in preventing biofilm formation on
Externí odkaz:
https://doaj.org/article/b617e0421dbf433f8dde8132f9b763e5
Autor:
F. Xavier Gomis-Rüth, Walter Stöcker
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
The astacins are a family of metallopeptidases (MPs) that has been extensively described from animals. They are multidomain extracellular proteins, which have a conserved core architecture encompassing a signal peptide for secretion, a prodomain or p
Externí odkaz:
https://doaj.org/article/f53d6c1bc77941aabec8067eb5f26591
Autor:
Marta Palau, Estela Muñoz, Enric Lujan, Nieves Larrosa, Xavier Gomis, Ester Márquez, Oscar Len, Benito Almirante, Jordi Abellà, Sergi Colominas, Joan Gavaldà
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT The aims of this study were as follows. First, we determined the antimicrobial efficacy of hypochlorous acid (HClO) against bacterial, fungal, and yeast strains growing planktonically and growing in biofilms. Second, we sought to compare the
Externí odkaz:
https://doaj.org/article/16cdc69f49bd4d019870a0e958cf33ea