Zobrazeno 1 - 10
of 713
pro vyhledávání: '"Xavier, Estivill"'
Autor:
Léa Maitre, Mariona Bustamante, Carles Hernández-Ferrer, Denise Thiel, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, Dolors Pelegrí-Sisó, Oliver Robinson, Dan Mason, John Wright, Solène Cadiou, Rémy Slama, Barbara Heude, Maribel Casas, Jordi Sunyer, Eleni Z. Papadopoulou, Kristine B. Gutzkow, Sandra Andrusaityte, Regina Grazuleviciene, Marina Vafeiadi, Leda Chatzi, Amrit K. Sakhi, Cathrine Thomsen, Ibon Tamayo, Mark Nieuwenhuijsen, Jose Urquiza, Eva Borràs, Eduard Sabidó, Inés Quintela, Ángel Carracedo, Xavier Estivill, Muireann Coen, Juan R. González, Hector C. Keun, Martine Vrijheid
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Environmental exposures in early life can have lasting health effects, but the molecular mechanisms are not well understood. Here, the authors discover >1000 associations between exposure factors and child multi-omics profiles, revealing signatures f
Externí odkaz:
https://doaj.org/article/96a767067f1c44eaaabd9e7fb53ce4fe
Autor:
Puthen Veettil Jithesh, Mohammed Abuhaliqa, Najeeb Syed, Ikhlak Ahmed, Mohammed El Anbari, Kholoud Bastaki, Shimaa Sherif, Umm-Kulthum Umlai, Zainab Jan, Geethanjali Gandhi, Chidambaram Manickam, Senthil Selvaraj, Chinnu George, Dhinoth Bangarusamy, Rania Abdel-latif, Mashael Al-Shafai, Zohreh Tatari-Calderone, Xavier Estivill, Munir Pirmohamed, The Qatar Genome Program Research Consortium
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is lagging in many parts
Externí odkaz:
https://doaj.org/article/c314b59c9cbb499c9aff4aa493e6fdd4
Autor:
Laura Domènech, Jesse Willis, Maria Alemany-Navarro, Marta Morell, Eva Real, Geòrgia Escaramís, Sara Bertolín, Daniel Sánchez Chinchilla, Susanna Balcells, Cinto Segalàs, Xavier Estivill, Jose M. Menchón, Toni Gabaldón, Pino Alonso, Raquel Rabionet
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Although the etiology of obsessive–compulsive disorder (OCD) is largely unknown, it is accepted that OCD is a complex disorder. There is a known bi-directional interaction between the gut microbiome and brain activity. Several authors have
Externí odkaz:
https://doaj.org/article/a15dfc880161498f883cf184d945b8ca
Autor:
Marta Gallego-Paüls, Carles Hernández-Ferrer, Mariona Bustamante, Xavier Basagaña, Jose Barrera-Gómez, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, John Wright, Remy Slama, Barbara Heude, Maribel Casas, Regina Grazuleviciene, Leda Chatzi, Eva Borràs, Eduard Sabidó, Ángel Carracedo, Xavier Estivill, Jose Urquiza, Muireann Coen, Hector C. Keun, Juan R. González, Martine Vrijheid, Léa Maitre
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background Multiple omics technologies are increasingly applied to detect early, subtle molecular responses to environmental stressors for future disease risk prevention. However, there is an urgent need for further evaluation of stability a
Externí odkaz:
https://doaj.org/article/0af1a0e49f6046f897308387634091ab
Autor:
Carlos Ruiz-Arenas, Carles Hernandez-Ferrer, Marta Vives-Usano, Sergi Marí, Ines Quintela, Dan Mason, Solène Cadiou, Maribel Casas, Sandra Andrusaityte, Kristine Bjerve Gutzkow, Marina Vafeiadi, John Wright, Johanna Lepeule, Regina Grazuleviciene, Leda Chatzi, Ángel Carracedo, Xavier Estivill, Eulàlia Marti, Geòrgia Escaramís, Martine Vrijheid, Juan R González, Mariona Bustamante
Publikováno v:
eLife, Vol 11 (2022)
Background: The identification of expression quantitative trait methylation (eQTMs), defined as associations between DNA methylation levels and gene expression, might help the biological interpretation of epigenome-wide association studies (EWAS). We
Externí odkaz:
https://doaj.org/article/3013a8cb16d340668b576973cce05265
Autor:
Marta Vives-Usano, Carles Hernandez-Ferrer, Léa Maitre, Carlos Ruiz-Arenas, Sandra Andrusaityte, Eva Borràs, Ángel Carracedo, Maribel Casas, Leda Chatzi, Muireann Coen, Xavier Estivill, Juan R. González, Regina Grazuleviciene, Kristine B. Gutzkow, Hector C. Keun, Chung-Ho E. Lau, Solène Cadiou, Johanna Lepeule, Dan Mason, Inés Quintela, Oliver Robinson, Eduard Sabidó, Gillian Santorelli, Per E. Schwarze, Alexandros P. Siskos, Rémy Slama, Marina Vafeiadi, Eulàlia Martí, Martine Vrijheid, Mariona Bustamante
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-19 (2020)
Abstract Background The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite of this, the underlying molecular mechanisms of in utero and postnatal exposure to tobacco smoke are only partially understoo
Externí odkaz:
https://doaj.org/article/a5a1962191e345a4a1e5e5da32ee69bb
Autor:
Kholoud N. Al‐Shafai, Mohammed Al‐Hashemi, Chidambaram Manickam, Rania Musa, Senthil Selvaraj, Najeeb Syed, Fazulur Vempalli, Muneera Ali, Magdi Yacoub, Xavier Estivill
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 7, Pp n/a-n/a (2021)
Abstract Background Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are serious inherited heart diseases with various causative mutations identified. The full spectrum of causative mutations remains to be discovered, especially in
Externí odkaz:
https://doaj.org/article/53125386f953446a93859046b5f1236f
Autor:
Christos Tziotzios, Christos Petridis, Nick Dand, Chrysanthi Ainali, Jake R. Saklatvala, Venu Pullabhatla, Alexandros Onoufriadis, Rashida Pramanik, David Baudry, Sang Hyuck Lee, Kristie Wood, Lu Liu, Seth Seegobin, Gregory A. Michelotti, Su M. Lwin, Evangelos A. A. Christou, Charles J. Curtis, Emanuele de Rinaldis, Alka Saxena, Susan Holmes, Matthew Harries, Ioulios Palamaras, Fiona Cunningham, Gregory Parkins, Manjit Kaur, Paul Farrant, Andrew McDonagh, Andrew Messenger, Jennifer Jones, Victoria Jolliffe, Iaisha Ali, Michael Ardern-Jones, Charles Mitchell, Nigel Burrows, Ravinder Atkar, Cedric Banfield, Anton Alexandroff, Caroline Champagne, Hywel L. Cooper, Sergio Vañó-Galván, Ana Maria Molina-Ruiz, Nerea Ormaechea Perez, Girish K. Patel, Abby Macbeth, Melanie Page, Alyson Bryden, Megan Mowbray, Shyamal Wahie, Keith Armstrong, Nicola Cooke, Mark Goodfield, Irene Man, David de Berker, Giles Dunnill, Anita Takwale, Archana Rao, Tee-Wei Siah, Rodney Sinclair, Martin S. Wade, Ncoza C. Dlova, Jane Setterfield, Fiona Lewis, Kapil Bhargava, Niall Kirkpatrick, Xavier Estivill, Catherine M. Stefanato, Carsten Flohr, Timothy Spector, Fiona M. Watt, Catherine H. Smith, Jonathan N. Barker, David A. Fenton, Michael A. Simpson, John A. McGrath
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation whi
Externí odkaz:
https://doaj.org/article/2a42af5d272646528b4002af71d71088
Autor:
Wenjing Kang, Yrin Eldfjell, Bastian Fromm, Xavier Estivill, Inna Biryukova, Marc R. Friedländer
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract We present here miRTrace, the first algorithm to trace microRNA sequencing data back to their taxonomic origins. This is a challenge with profound implications for forensics, parasitology, food control, and research settings where cross-cont
Externí odkaz:
https://doaj.org/article/47f900a9cfb6434682d1d9fd0af9ed9e
Autor:
Hana Susak, Laura Serra-Saurina, German Demidov, Raquel Rabionet, Laura Domènech, Mattia Bosio, Francesc Muyas, Xavier Estivill, Geòrgia Escaramís, Stephan Ossowski
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1007784 (2021)
Rare variants are thought to play an important role in the etiology of complex diseases and may explain a significant fraction of the missing heritability in genetic disease studies. Next-generation sequencing facilitates the association of rare vari
Externí odkaz:
https://doaj.org/article/54394f1fe61b4efea767e89a29b01672